4.6 Article

Multiscale Monte Carlo simulations of gold nanoparticle dose-enhanced radiotherapy II. Cellular dose enhancement within macroscopic tumor models

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Multiscale Monte Carlo simulations of gold nanoparticle dose-enhanced radiotherapy II. Cellular dose enhancement within macroscopic tumor models

Martin P. P. Martinov et al.

Summary: This study used multiscale Monte Carlo simulations to evaluate variations in cytoplasm and nucleus dose enhancement factors over tumor volumes. The results showed that cell/nucleus size, gold particle distribution, gold concentration, and cell position in the tumor all had significant effects on the dose. This highlights the importance of choosing the proper computational model and accounting for intrinsic variations in cell/nucleus size and gold concentration when simulating gold nanoparticle dose-enhanced radiation therapy.

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