Temporal changes in muscle characteristics during growth in the goat

This study aimed to explore the temporal accumulative process of functional components and take insight into their dynamic regulatory metabolic pathways in the longissimus during growth in goats. Results showed that the intermuscular fat content, cross-sectional area and fast- to slow-switch fiber ratio of the longissimus were synchronously increased from d1 to d90. The dynamic profiles of functional components and transcriptomic pathways of the longissimus both exhibited two distinct phases during animal development. Expression of genes involved in de novo lipogenesis was increased from birth to weaning, leading to the accumulation of palmitic acid in the first phase. Accumulation of functional oleic acid, linoleic acid and linolenic acid in the second phase was dominatingly driven by enhancement in expression of genes related to fatty acid elongation and desaturation after weaning. A shift from serine to glycine production was observed after weaning, which was linked to the expression profile of genes involved in their interconversion. Our findings systematically reported the key window and pivotal targets of the functional components' accumulation process in the chevon.

Automated summary

This study aimed to explore the temporal accumulative process of functional components and their dynamic regulatory metabolic pathways in the longissimus during growth in goats. The results showed that the longissimus exhibited synchronously increased intermuscular fat content, cross-sectional area, and fast- to slow-switch fiber ratio during the growth period. The functional components and transcriptomic pathways of the longissimus exhibited two distinct phases, with genes related to de novo lipogenesis contributing to the accumulation of palmitic acid in the first phase, and genes involved in fatty acid elongation and desaturation driving the accumulation of oleic acid, linoleic acid, and linolenic acid in the second phase.