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Tumor-associated fibrosis impairs the response to immunotherapy

MATRIX BIOLOGY (2023)

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Redefining Tumor-Associated Macrophage Subpopulations and Functions in the Tumor Microenvironment

Kaiyue Wu et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Review Cell Biology

Surmounting the obstacles that impede effective CAR T cell trafficking to solid tumors

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JOURNAL OF LEUKOCYTE BIOLOGY (2020)

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Article Biochemistry & Molecular Biology

The tumor microenvironment

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CURRENT BIOLOGY (2020)

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Editorial Material Immunology

T cells in COVID-19-united in diversity

Leo Swadling et al.

NATURE IMMUNOLOGY (2020)

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Article Multidisciplinary Sciences

Collagen promotes anti-PD-1/PD-L1 resistance in cancer through LAIR1-dependent CD8+ T cell exhaustion

David H. Peng et al.

NATURE COMMUNICATIONS (2020)

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Article Oncology

Immune Remodeling of the Extracellular Matrix Drives Loss of Cancer Stem Cells and Tumor Rejection

Ana Pires et al.

CANCER IMMUNOLOGY RESEARCH (2020)

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Cancer-associated fibroblasts an their influence on tumor immunity and immunotherapy

Richard Lee Barrett et al.

ELIFE (2020)

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Review Immunology

Tumor-Associated Macrophages in Tumor Immunity

Yueyun Pan et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Review Biochemistry & Molecular Biology

Transforming Growth Factor-β Signaling in Fibrotic Diseases and Cancer-Associated Fibroblasts

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BIOMOLECULES (2020)

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Article Medicine, Research & Experimental

TGF-β inhibition combined with cytotoxic nanomedicine normalizes triple negative breast cancer microenvironment towards anti-tumor immunity

Myrofora Panagi et al.

THERANOSTICS (2020)

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Review Oncology

A review of cancer immunotherapy: from the past, to the present, to the future

K. Esfahani et al.

CURRENT ONCOLOGY (2020)

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A framework for advancing our understanding of cancer-associated fibroblasts

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NATURE REVIEWS CANCER (2020)

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A guide to cancer immunotherapy: from T cell basic science to clinical practice

Alex D. Waldman et al.

NATURE REVIEWS IMMUNOLOGY (2020)

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Remodeling the fibrotic tumor microenvironment of desmoplastic melanoma to facilitate vaccine immunotherapy

Hongda Zhu et al.

NANOSCALE (2020)

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Review Oncology

CD8+ T cell states in human cancer: insights from single-cell analysis

Anne M. Van der Leun et al.

NATURE REVIEWS CANCER (2020)

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Review Biochemistry & Molecular Biology

Extracellular Matrix in the Tumor Microenvironment and Its Impact on Cancer Therapy

Erik Henke et al.

FRONTIERS IN MOLECULAR BIOSCIENCES (2020)

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Review Biochemistry & Molecular Biology

Killing Mechanisms of Chimeric Antigen Receptor (CAR) T Cells

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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Article Oncology

CYR61/CCN1 Regulates dCK and CTGF and Causes Gemcitabine-resistant Phenotype in Pancreatic Ductal Adenocarcinoma

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MOLECULAR CANCER THERAPEUTICS (2019)

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Article Multidisciplinary Sciences

Blocking CXCR4 alleviates desmoplasia, increases T-lymphocyte infiltration, and improves immunotherapy in metastatic breast cancer

Ivy X. Chen et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

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The double edge sword of fibrosis in cancer

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TRANSLATIONAL RESEARCH (2019)

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Cancer associated fibroblasts sculpt tumour microenvironment by recruiting monocytes and inducing immunosuppressive PD-1+ TAMs

Betul Gokyavuz et al.

SCIENTIFIC REPORTS (2019)

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Collagen density regulates the activity of tumor-infiltrating T cells

Dorota E. Kuczek et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2019)

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Review Oncology

Current Challenges in Cancer Immunotherapy: Multimodal Approaches to Improve Efficacy and Patient Response Rates

Manpreet Sambi et al.

JOURNAL OF ONCOLOGY (2019)

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Stroma in normal and cancer wound healing

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FEBS JOURNAL (2019)

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Article Cell Biology

HIF-1α Is a Metabolic Switch between Glycolytic-Driven Migration and Oxidative Phosphorylation-Driven Immunosuppression of Tregs in Glioblastoma

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CELL REPORTS (2019)

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Article Oncology

Anticancer Immunotherapy by MFAP5 Blockade Inhibits Fibrosis and Enhances Chemosensitivity in Ovarian and Pancreatic Cancer

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CLINICAL CANCER RESEARCH (2019)

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Review Oncology

The Emerging Role of YAP/TAZ in Tumor Immunity

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MOLECULAR CANCER RESEARCH (2019)

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Article Immunology

Poly-ICLC, a TLR3 Agonist, Induces Transient Innate Immune Responses in Patients With Treated HIV-Infection: A Randomized Double-Blinded Placebo Controlled Trial

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FRONTIERS IN IMMUNOLOGY (2019)

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Review Oncology

Cancer-associated fibroblasts: an emerging target of anti-cancer immunotherapy

Tongyan Liu et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2019)

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Review Oncology

The clinical role of the TME in solid cancer

Nicolas A. Giraldo et al.

BRITISH JOURNAL OF CANCER (2019)

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Review Biochemistry & Molecular Biology

Role of the tumor microenvironment in PD-L1/PD-1-mediated tumor immune escape

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MOLECULAR CANCER (2019)

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Differential control of human Treg and effector T cells in tumor immunity by Fc-engineered anti-CTLA-4 antibody

Danbee Ha et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

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Review Immunology

The Intriguing History of Cancer Immunotherapy

Paula Dobosz et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Review Oncology

CAF Subpopulations: A New Reservoir of Stromal Targets in Pancreatic Cancer

Brooke A. Pereira et al.

TRENDS IN CANCER (2019)

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Review Oncology

Hypoxia as a barrier to immunotherapy in pancreatic adenocarcinoma

S. K. Daniel et al.

CLINICAL AND TRANSLATIONAL MEDICINE (2019)

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Review Biochemistry & Molecular Biology

Current Progress in CAR-T Cell Therapy for Solid Tumors

Shuo Ma et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2019)

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Integrins in wound healing, fibrosis and tumor stroma: High potential targets for therapeutics and drug delivery

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ADVANCED DRUG DELIVERY REVIEWS (2018)

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Cancer-Associated Fibroblasts Affect Intratumoral CD8+ and FoxP3+ T Cells Via IL6 in the Tumor Microenvironment

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CLINICAL CANCER RESEARCH (2018)

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Activation of cancer-associated fibroblasts is required for tumor neovascularization in a murine model of melanoma

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MATRIX BIOLOGY (2018)

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YAP Is Essential for Treg-Mediated Suppression of Antitumor Immunity

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CANCER DISCOVERY (2018)

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Talimogene laherparepvec: First in class oncolytic virotherapy

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HUMAN VACCINES & IMMUNOTHERAPEUTICS (2018)

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Review Immunology

Tissue-Dependent Tumor Microenvironments and Their impact on immunotherapy Responses

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FRONTIERS IN IMMUNOLOGY (2018)

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Review Oncology

Anti-PD-1 and Anti-CTLA-4 Therapies in Cancer: Mechanisms of Action, efficacy, and Limitations

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FRONTIERS IN ONCOLOGY (2018)

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Article Medicine, Research & Experimental

Targeted hypoxia reduction restores T cell infiltration and sensitizes prostate cancer to immunotherapy

Priyamvada Jayaprakash et al.

JOURNAL OF CLINICAL INVESTIGATION (2018)

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Review Immunology

Reactive Oxygen Species as Regulators of MDSC-Mediated Immune Suppression

Kim Ohl et al.

FRONTIERS IN IMMUNOLOGY (2018)

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TRENDS IN CANCER (2018)

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Review Immunology

CD4+ T cell help in cancer immunology and immunotherapy

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NATURE REVIEWS IMMUNOLOGY (2018)

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Significance of Intratumoral Fibrosis in Clear Cell Renal Cell Carcinoma

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JOURNAL OF PATHOLOGY AND TRANSLATIONAL MEDICINE (2018)

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Article Biotechnology & Applied Microbiology

Recombinant human granulocyte macrophage colony stimulating factor (hGM-CSF): Possibility of nanoparticle-mediated delivery in cancer immunotherapy

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BIOENGINEERED (2017)

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Article Immunology

Integrin-targeted cancer immunotherapy elicits protective adaptive immune responses

Byron H. Kwan et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2017)

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Article Pathology

Fibrotic focus: An important parameter for accurate prediction of a high level of tumor-associated macrophage infiltration in invasive ductal carcinoma of the breast

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PATHOLOGY INTERNATIONAL (2017)

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Towards integrating extracellular matrix and immunological pathways

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CYTOKINE (2017)

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Immunotherapy in ovarian cancer

K. Odunsi

ANNALS OF ONCOLOGY (2017)

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Article Biochemistry & Molecular Biology

Hippo effector YAP directly regulates the expression of PD-L1 transcripts in EGFR-TKI-resistant lung adenocarcilloma

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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2017)

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Review Oncology

Tumor-associated fibrosis as a regulator of tumor immunity and response to immunotherapy

Hong Jiang et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2017)

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Article Oncology

Immunotherapy for Breast Cancer: What Are We Missing?

Robert H. Vonderheide et al.

CLINICAL CANCER RESEARCH (2017)

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Review Cell Biology

The emerging role of ECM crosslinking in T cell mobility as a hallmark of immunosenescence in humans

Jean-Francois Moreau et al.

AGEING RESEARCH REVIEWS (2017)

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Review Biochemistry & Molecular Biology

Primary, Adaptive, and Acquired Resistance to Cancer Immunotherapy

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CELL (2017)

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Tumor macrophages are pivotal constructors of tumor collagenous matrix

Ran Afik et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2016)

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Article Biochemistry & Molecular Biology

Targeting focal adhesion kinase renders pancreatic cancers responsive to checkpoint immunotherapy

Hong Jiang et al.

NATURE MEDICINE (2016)

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Article Multidisciplinary Sciences

Pegylated Interferon α-2a Triggers NK-Cell Functionality and Specific T-Cell Responses in Patients with Chronic HBV Infection without HBsAg Seroconversion

Juliana Bruder Costa et al.

PLOS ONE (2016)

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Article Oncology

Desmoplasia in Primary Tumors and Metastatic Lesions of Pancreatic Cancer

Clifford J. Whatcott et al.

CLINICAL CANCER RESEARCH (2015)

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Article Pharmacology & Pharmacy

Imiquimod - Its role in the treatment of cutaneous malignancies

Aditya Kumar Bubna

INDIAN JOURNAL OF PHARMACOLOGY (2015)

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Article Cell Biology

Spatial organization of the tenascin-C microenvironment in experimental and human cancer

Caroline Spenle et al.

CELL ADHESION & MIGRATION (2015)

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Article Oncology

Immune Escape Mechanisms as a Guide for Cancer Immunotherapy

Gregory L. Beatty et al.

CLINICAL CANCER RESEARCH (2015)

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Review Immunology

tTregs, pTregs, and iTregs: similarities and differences

Ethan M. Shevach et al.

IMMUNOLOGICAL REVIEWS (2014)

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Review Oncology

Hypoxia and the extracellular matrix: drivers of tumour metastasis

Daniele M. Gilkes et al.

NATURE REVIEWS CANCER (2014)

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Review Oncology

Matricellular proteins: priming the tumour microenvironment for cancer development and metastasis

G. S. Wong et al.

BRITISH JOURNAL OF CANCER (2013)

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Article Biochemical Research Methods

Tumor-associated macrophages and stromal TNF-α regulate collagen structure in a breast tumor model as visualized by second harmonic generation

Ryan M. Burke et al.

JOURNAL OF BIOMEDICAL OPTICS (2013)

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Article Multidisciplinary Sciences

Targeting CXCL12 from FAP-expressing carcinomaassociated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer

Christine Feig et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

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Review Immunology

Cancer-associated fibroblasts as targets for immunotherapy

Sunitha Kakarla et al.

IMMUNOTHERAPY (2012)

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Editorial Material Oncology

Desmoplasia: A Response or a Niche?

Yves A. DeClerck

CANCER DISCOVERY (2012)

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Review Cell Biology

The role of the myofibroblast in tumor stroma remodeling

Marcela Otranto et al.

CELL ADHESION & MIGRATION (2012)

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Article Pathology

Aligned Collagen Is a Prognostic Signature for Survival in Human Breast Carcinoma

Matthew W. Conklin et al.

AMERICAN JOURNAL OF PATHOLOGY (2011)

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Article Oncology

Matrix Metalloproteinases in Cytotoxic Lymphocytes Impact on Tumour Infiltration and Immunomodulation

Karin Edsparr et al.

CANCER MICROENVIRONMENT (2011)

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Review Immunology

Regulatory T cells: immune suppression and beyond

Yisong Y. Wan

CELLULAR & MOLECULAR IMMUNOLOGY (2010)

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Review Cell Biology

Tumors as Organs: Complex Tissues that Interface with the Entire Organism

Mikala Egeblad et al.

DEVELOPMENTAL CELL (2010)

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Editorial Material Immunology

How do Regulatory T Cells Work?

A. Corthay

SCANDINAVIAN JOURNAL OF IMMUNOLOGY (2009)

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Article Immunology

Galectin-1 functions as a Th2 cytokine that selectively induces Th1 apoptosis and promotes Th2 function

Claudia C. Motran et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2008)

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Review Oncology

Cellular and molecular mechanisms of fibrosis

T. A. Wynn

JOURNAL OF PATHOLOGY (2008)

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Review Genetics & Heredity

Hypoxia and cancer

M. Christiane Brahimi-Horn et al.

JOURNAL OF MOLECULAR MEDICINE-JMM (2007)

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Article Multidisciplinary Sciences

Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-β signals in vivoi

ML Chen et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

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Article Immunology

Distinct IL-2 receptor signaling pattern in CD4+CD25+ regulatory T cells

SJ Bensinger et al.

JOURNAL OF IMMUNOLOGY (2004)

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Article Oncology

Pegylated interferon alfa-2b treatment for patients with solid tumors: A phase I/II study

R Bukowski et al.

JOURNAL OF CLINICAL ONCOLOGY (2002)

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Article Pathology

Highly proliferative fibroblasts forming fibrotic focus govern metastasis of invasive ductal carcinoma of the breast

T Hasebe et al.

MODERN PATHOLOGY (2001)

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Article Pathology

Proliferative activity of intratumoral fibroblasts is closely correlated with lymph node and distant organ metastases of invasive ductal carcinoma of the breast

T Hasebe et al.

AMERICAN JOURNAL OF PATHOLOGY (2000)

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