Reduced model for female endocrine dynamics: Validation and functional variations

Article Biology

A phenomenological-based model of the endometrial growth and shedding during the menstrual cycle

Daniela Arbelaez-Gomez et al.

Summary: A dynamic model was developed to predict volume changes in the functional layer of the endometrium in each phase of the menstrual cycle. The model considers various factors and was validated using experimental data.

JOURNAL OF THEORETICAL BIOLOGY (2022)

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Article Endocrinology & Metabolism

Hormonal treatments for endometriosis: The endocrine background

Silvia Vannuccini et al.

Summary: Endometriosis is a chronic uterine disorder that affects women's health, and hormonal drugs are the main medical treatment used to manage the disease based on endocrine and inflammatory changes. The key events causing pain and infertility are estrogen-dependency and progesterone-resistance. Current treatments aim to inhibit menstruation, block the hypothalamus-pituitary-ovary axis, and control the progression of endometriotic implants.

REVIEWS IN ENDOCRINE & METABOLIC DISORDERS (2022)

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Article Biology

Hormonal regulation of ovarian follicle growth in humans: Model-based exploration of cycle variability and parameter sensitivities

Sophie Fischer-Holzhausen et al.

Summary: This study presents a modelling and simulation framework for studying the dynamics of ovarian follicles and key hormones during consecutive human menstrual cycles. The model takes into account the variability in follicles' response to stimulating hormones and uses Approximate Bayesian Computation and cluster analysis to construct a population of virtual subjects. The model is significant for comparing and optimizing treatment protocols for ovarian hyperstimulation.

JOURNAL OF THEORETICAL BIOLOGY (2022)

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Article Endocrinology & Metabolism

Ovarian Reserve Markers in Premature Ovarian Insufficiency: Within Different Clinical Stages and Different Etiologies

Xue Jiao et al.

Summary: Ovarian reserve indicators deteriorate with the progression of ovarian insufficiency, with an increase in FSH and LH but a decrease in AMH, inhibin B, AFC, E-2 and T. AMH has the highest predictive value for POI, and the combination of AMH and AFC is promising for early prediction. Significant differences exist in hormone status among women with different etiologies of POI, with genetic POI showing the worst hormone status.

FRONTIERS IN ENDOCRINOLOGY (2021)

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Article Multidisciplinary Sciences

Treatment pathways traversed by polycystic ovary syndrome (PCOS) patients: A mixed-method study

Ishwarpreet Kaur et al.

Summary: The study aimed to explore treatment-seeking pathways of women with PCOS. Many participants had little information about PCOS, turned to the internet for information but were dissatisfied. Most consulted multiple healthcare agencies and preferred allopathy. Patients experienced delays in treatment initiation and were dissatisfied with quality of information and treatment received.

PLOS ONE (2021)

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Review Cell Biology

Pathogenesis of Endometriosis: The Origin of Pain and Subfertility

Teresa Mira Gruber et al.

Summary: Endometriosis and adenomyosis often result in pain and infertility as main symptoms. The pain is caused by sensory and somatoform mechanisms, and if left untreated, may lead to chronic pain and complex disease patterns.

CELLS (2021)

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Review Biochemistry & Molecular Biology