Multifunctional glycoprotein coatings improve the surface properties of highly oxygen permeable contact lenses

To achieve and maintain good operability of medical devices while reducing putative side effects for the patient, a promising strategy is to tailor the surface properties of such devices as they critically dictate the tissue compatibility and the biofouling behavior. Indeed, those properties can be strongly improved by generating mucin coatings on such medical devices. However, using coatings on optical systems, e.g., contact lenses, comes with various challenges: here, the geometrical and optical characteristics of the lens may not be compromised by either the coating process or the coating itself. In this study, we show how mucin macromolecules can be attached onto the surfaces of rigid, gas permeable contact lenses while maintaining all critical lens parameters. We demonstrate that the generated coatings improve the surface wettability (contact angles are reduced from 105 degrees to 40 degrees and liquid film break-up times are increased from <1 s to 31 s) and prevent tribological damage to corneal tissue. Additionally, such coatings are highly transparent (transmission values above 98 % compared to an uncoated sample are reached) and efficiently reduce lipid deposition to the lens surface by 90 % but fully maintain the geometrical and mechanical properties of the lenses. Thus, such mucin coatings could also be highly beneficial for other optical systems that are used in direct contact with tissues or body fluids.

Automated summary

In order to improve the operability and reduce side effects of medical devices, researchers have found that mucin coatings can greatly enhance their surface properties. However, applying coatings to optical systems like contact lenses poses challenges. This study demonstrates that mucin macromolecules can be attached to gas permeable contact lenses without compromising their critical parameters and significantly improving their wettability, preventing tribological damage, and reducing lipid deposition while maintaining their transparency and mechanical properties.