期刊
MATERIALS LETTERS
卷 334, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.matlet.2022.133671
关键词
Nanoparticles; Laser processing; Structural; MTT assay; Anticancer
Surface functionalized silver-cinnamon nanoshells (Ag-CNSs) were synthesized using PLAL method and characterized. The anticancer effectiveness and cytotoxicity of Ag-CNSs against liver hepatocellular carcinoma cancer (HepG2) and normal (WRL68) cell lines were evaluated. The Ag-CNSs exhibited strong anticancer activity and improved fluorescence and surface plasmon resonance (SPR) absorption.
New types of surface functionalized silver-cinnamon nanoshells (Ag-CNSs) were produced in deionized water using PLAL method and characterized. Anticancer effectiveness and cytotoxicity of these Ag-CNSs against liver hepatocellular carcinoma cancer (HepG2) and normal (WRL68) cell lines was evaluated. XRD and EDX analyses of Ag-CNSs showed their excellent crystallinity and elemental compositions. HRTEM micrographs displayed the existence of cinnamon protein-capped spherical Ag nanocrystallites of size 11.12 +/- 1.32 nm. These ultra -sensitive Ag-CNSs with wide surface area revealed an improved fluorescence and surface plasmon resonance (SPR) absorption. The achieved Ag-CNSs exhibited strong anticancer activity (high cytotoxicity, log IC50 approximate to 59.1 %), indicating the feasibility of developing novel drugs for cancer cure. It was shown that via the surface functionalization, the anticancer efficacy of the proposed Ag-CNSs can be tailored.
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