Electrospinning of cotton-like fibers based on cerium-doped sol-gel bioactive glass

In this study, Ce-doped calcium silicate-based bioactive glass sols were electrospun under well-defined parameters and heat-treated to obtain cotton-like fibrous structures. The 3D structures comprised long and entangled fibers with interconnected pores, and the successful incorporation of Ce was confirmed by EDX analysis. The fibers were highly hydrophilic and demonstrated in vitro bioactivity after immersion in simulated body fluid. The fibers were non-cytotoxic toward keratinocytes and did not inhibit the wound closure process, which was characterized in vitro.

Automated summary

Ce-doped calcium silicate-based bioactive glass sols were electrospun and heat-treated to form cotton-like fibrous structures. The 3D structures consisted of long and entangled fibers with interconnected pores, and the successful incorporation of Ce was confirmed by EDX analysis. The fibers exhibited high hydrophilicity and in vitro bioactivity in simulated body fluid. They showed no cytotoxicity to keratinocytes and did not hinder the wound closure process in vitro.