New Insights into the Mechanism of Ulva pertusa on Colitis in Mice: Modulation of the Pain and Immune System

Article Cell Biology

Investigation of TLR4 Antagonists for Prevention of Intestinal Inflammation

Janine S. Y. Tam et al.

Summary: This study found that specific inhibition of TLR4 using TAK-242 and IAXO-102 was not effective in blocking intestinal mucositis. Instead, TLR4 signaling through immune cells may be a more important target for preventing mucositis.

INFLAMMATION (2023)

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Review Gastroenterology & Hepatology

Immune-mediated inflammatory diseases of the gastrointestinal tract: Beyond Crohn's disease and ulcerative colitis

Sudheer K. Vuyyuru et al.

Summary: Immune-mediated inflammatory diseases (IMIDs) are a diverse group of complex inflammatory diseases that can affect any system of the human body. Inflammatory bowel disease (IBD) is a specific type of IMID that involves the gastrointestinal system. It is important to distinguish other GI tract IMIDs from IBD due to their similar clinical features and shared pathophysiology.

JGH OPEN (2022)

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Article Biochemistry & Molecular Biology

Efficacy of a Product Containing Xyloglucan and Pea Protein on Intestinal Barrier Function in a Partial Restraint Stress Animal Model

Sarah Adriana Scuderi et al.

Summary: This study investigated the effect of xyloglucan and pea-protein on functional abdominal bloating and distension (FABD) in a stress-induced rat model. The results showed that pre-treatment with these natural substances reduced abdominal contractions, visceral hypersensitivity, and restored intestinal barrier function. Therefore, xyloglucan and pea-protein could be considered a therapeutic strategy for managing FABD.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Plant Sciences

Ethanolic extract from Lepidium virginicum L. ameliorates DNBS-induced colitis in rats

Jose R. Cruz-Munoz et al.

Summary: The ethanolic extract of Lepidium virginicum L. has anti-inflammatory properties in the treatment of inflammatory bowel disease.

JOURNAL OF ETHNOPHARMACOLOGY (2022)

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Article Nutrition & Dietetics

Efficacy of a Novel Therapeutic, Based on Natural Ingredients and Probiotics, in a Murine Model of Multiple Food Intolerance and Maldigestion

Alessio Ardizzone et al.

Summary: This study aimed to evaluate the effectiveness of a natural therapeutic method in a mouse model of food intolerance. The results showed that the treatment successfully restored intestinal function compromised by intolerances and improved tissue damage.

NUTRIENTS (2022)

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Article Medicine, General & Internal

Ulva pertusa, a Marine Green Alga, Attenuates DNBS-Induced Colitis Damage via NF-κB/Nrf2/SIRT1 Signaling Pathways

Alessio Ardizzone et al.

Summary: Inflammatory bowel diseases are gastrointestinal disorders associated with microbial and environmental factors. Natural compounds like Ulva pertusa can be used as a valid approach for the management of these diseases. This study found that Ulva pertusa can reduce tissue damage and inflammatory response by modulating the NF-kappa B/SIRT1/Nrf2 axis.

JOURNAL OF CLINICAL MEDICINE (2022)

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Review Chemistry, Medicinal

The role of medicinal products in the treatment of inflammatory bowel diseases (IBD) through inhibition ofTLR4/NF-kappaBpathway

Pegah Dejban et al.

Summary: Inflammatory bowel disease (IBD) is a lifelong and recurrent gastrointestinal disease, with immune system dysfunction, particularly toll-like receptors 4 (TLR4) signaling pathway dysfunction, playing a crucial role in its pathogenesis. TLR4 signaling is important in both the development and treatment efficacy of IBD. Medicinal products and herbal medicines have been implicated in the treatment of IBD through modulation of TLR4 signaling.

PHYTOTHERAPY RESEARCH (2021)

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Article Pharmacology & Pharmacy

Therapeutic potential of flavonoids in the treatment of chronic venous insufficiency

Giovanna Casili et al.

Summary: Chronic venous insufficiency is a common disorder with various symptoms in later stages, for which suitable pharmaceutical therapies have not been explored. Flavonoids play a key role in circulation and some compounds enriched with flavonoids have therapeutic potential to reduce varicose vein pathophysiology. This research highlights the importance of flavonoids in managing vascular diseases.

VASCULAR PHARMACOLOGY (2021)

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Review Immunology

NLRP3 Inflammasome: Checkpoint Connecting Innate and Adaptive Immunity in Autoimmune Diseases

Yiwen Zhang et al.

Summary: Autoimmune diseases result from immune tolerance breakdown and autoantibody production; NLRP3 inflammasome is crucial in the pathogenesis of autoimmune diseases and may serve as a potential therapeutic target.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Cell Biology

Carbonic Anhydrase IV Selective Inhibitors Counteract the Development of Colitis-Associated Visceral Pain in Rats

Elena Lucarini et al.

Summary: This study showed that selective CA IV inhibitors AB-118 and NIK-67 effectively counteracted visceral pain induced by DNBS in rats, with AB-118 also showing a protective effect against colon damage.

CELLS (2021)

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Article Chemistry, Medicinal

Intestinal Anti-Inflammatory Effects of Selenized Ulva pertusa Polysaccharides in a Dextran Sulfate Sodium-Induced Inflammatory Bowel Disease Model

Yifan Wang et al.

Summary: The study demonstrates that selenized polysaccharides from Ulva pertusa have alleviative effects on inflammatory bowel disease in mice by promoting intestinal mechanical and immune barrier functions, thus reducing intestinal inflammation levels.

JOURNAL OF MEDICINAL FOOD (2021)

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Article Biochemistry & Molecular Biology

Co-Ultra PEALut Enhances Endogenous Repair Response Following Moderate Traumatic Brain Injury

Michela Campolo et al.

Summary: The study demonstrated that co-ultramicronized PEALut treatment can promote neurogenesis, increase levels of neurotrophic factors, improve memory recall, and facilitate neural recovery in working memory in clinical trials.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Nanoscience & Nanotechnology

Current Strategies and Potential Prospects of Nanomedicine-Mediated Therapy in Inflammatory Bowel Disease

Fengqian Chen et al.

Summary: Inflammatory bowel diseases (IBD) such as Crohn's disease and ulcerative colitis are highly debilitating due to the imbalance of inflammatory mediators within the inflamed bowel. Conventional drugs for IBD treatment suffer from bioavailability issues and systemic side effects, while nanoparticle (NP)-derived therapy has shown improvements in therapeutic efficacy and targeting specificity. Recent studies have highlighted the fast-growing field of nanomedicines tailored to the pathophysiology of bowel diseases, offering potential for prolonged circulation period and reduced side effects through improved drug encapsulation and targeted delivery.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2021)

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Review Pharmacology & Pharmacy

Natural Anti-Inflammatory Compounds as Drug Candidates for Inflammatory Bowel Disease

Linshan Duan et al.

Summary: Inflammatory bowel disease (IBD) is a chronic intestinal inflammation caused by various factors, with Crohn's disease and ulcerative colitis being the two major types. Most commonly used drugs for IBD have adverse reactions and limited long-term efficacy, leading to challenges in treating patients. Research suggests that natural compounds with anti-inflammatory activities could offer potential therapeutic strategies for IBD.

FRONTIERS IN PHARMACOLOGY (2021)

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Article Biochemistry & Molecular Biology

Hidrox(R) and Chronic Cystitis: Biochemical Evaluation of Inflammation, Oxidative Stress, and Pain

Ramona D'Amico et al.

Summary: The study evaluated the anti-inflammatory and antioxidant effects of oral administration of Hidrox(R) in a rodent model of IC/BPS, showing improvement in CYP-induced inflammation and oxidative stress, reduction in bladder pain, and decrease in neuroinflammation in the central nervous system.

ANTIOXIDANTS (2021)

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Review Gastroenterology & Hepatology

Post-inflammatory Abdominal Pain in Patients with Inflammatory Bowel Disease During Remission: A Comprehensive Review

Kazuya Takahashi et al.

Summary: Patients with inflammatory bowel disease may experience ongoing pain even after mucosal healing due to factors related to the brain-gut axis. A comprehensive study exploring the interaction between various predisposing factors is needed to fully understand the complex mechanism, and new treatments consistent with the underlying pathophysiology are required to improve clinical outcomes.

CROHNS & COLITIS 360 (2021)

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Review Gastroenterology & Hepatology

Post-inflammatory Abdominal Pain in Patients with Inflammatory Bowel Disease During Remission: A Comprehensive Review

Kazuya Takahashi et al.

Summary: Patients with inflammatory bowel disease may experience ongoing pain even after mucosal healing, with factors related to the brain-gut axis playing a significant role. Further comprehensive studies on multiple predisposing factors are needed, along with new treatments based on underlying pathophysiology to improve clinical outcomes.

CROHNS & COLITIS 360 (2021)

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Article Immunology

Survivin Impairs the Apoptotic Machinery in CD4+ T Cells of Patients with Ulcerative Colitis

Bai-Sui Feng et al.

JOURNAL OF INNATE IMMUNITY (2020)

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Review Gastroenterology & Hepatology

First- and Second-Line Pharmacotherapies for Patients With Moderate to Severely Active Ulcerative Colitis: An Updated Network Meta-Analysis

Siddharth Singh et al.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2020)

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Article Biochemistry & Molecular Biology

Effect of a Product Containing Xyloglucan and Pea Protein on a Murine Model of Atopic Dermatitis

Michela Campolo et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Review Biochemistry & Molecular Biology

Does NLRP3 Inflammasome and Aryl Hydrocarbon Receptor Play an Interlinked Role in Bowel Inflammation and Colitis-Associated Colorectal Cancer?

Ivan Qi Han Ngui et al.

MOLECULES (2020)

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Review Biochemistry & Molecular Biology

The relationship between intestinal goblet cells and the immune response

Mingming Zhang et al.

BIOSCIENCE REPORTS (2020)

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Review Gastroenterology & Hepatology

Mesalamine in the Initial Therapy of Ulcerative Colitis

Richa Chibbar et al.

GASTROENTEROLOGY CLINICS OF NORTH AMERICA (2020)

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Article Oncology

Clinical Trials of IL-12/IL-23 Inhibitors in Inflammatory Bowel Disease

Ahmed Almradi et al.

BIODRUGS (2020)

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Article Pharmacology & Pharmacy

Formyl peptide receptor 1 signalling promotes experimental colitis in mice

Rosanna Di Paola et al.

PHARMACOLOGICAL RESEARCH (2019)

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Article Immunology

Melatonin ameliorates TNBS-induced colitis in rats through the melatonin receptors: involvement of TLR4/MyD88/NF-B signalling pathway

Mohsen Chamanara et al.

INFLAMMOPHARMACOLOGY (2019)

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Review Microbiology

Inflammatory Bowel Disease: A Potential Result from the Collusion between Gut Microbiota and Mucosal Immune System

Bei Yue et al.

MICROORGANISMS (2019)

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Article Biochemistry & Molecular Biology

Macrophages treated with antigen from the tapeworm Hymenolepis diminuta condition CD25+ T cells to suppress colitis

Jose L. Reyes et al.

FASEB JOURNAL (2019)

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Review Immunology

NLRP3 Inflammasome and Inflammatory Bowel Disease

Yu Zhen et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Article Plant Sciences

Comparison of the TLR4/NFκB and NLRP3 signalling pathways in major organs of the mouse after intravenous injection of lipopolysaccharide

Qin Gong et al.

PHARMACEUTICAL BIOLOGY (2019)

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Article Gastroenterology & Hepatology

Rebamipide alleviates radiation-induced colitis through improvement of goblet cell differentiation in mice

Hyosun Jang et al.

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2018)

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Article Biochemistry & Molecular Biology

Curcumin alleviates DSS-induced colitis via inhibiting NLRP3 inflammsome activation and IL-1β production

Zizhen Gong et al.

MOLECULAR IMMUNOLOGY (2018)

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Article Immunology

Cutting Edge: TRAF6 Mediates TLR/IL-1R Signaling-Induced Nontranscriptional Priming of the NLRP3 Inflammasome

Yue Xing et al.

JOURNAL OF IMMUNOLOGY (2017)

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Article Neurosciences

Oral administration of curcumin attenuates visceral hyperalgesia through inhibiting phosphorylation of TRPV1 in rat model of ulcerative colitis

Mei Yang et al.

MOLECULAR PAIN (2017)

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Review Immunology

Anti-Adhesion Therapies in inflammatory Bowel Disease-Molecular and Clinical Aspects

Sebastian Zundler et al.

FRONTIERS IN IMMUNOLOGY (2017)

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Review Medicine, Research & Experimental

Cells of the innate and adaptive immunity and their interactions in inflammatory bowel disease

Zbigniew Kmiec et al.

ADVANCES IN MEDICAL SCIENCES (2017)

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Article Neurosciences

Traumatic Brain Injury Leads to Development of Parkinson's Disease Related Pathology in Mice

Daniela Impellizzeri et al.

FRONTIERS IN NEUROSCIENCE (2016)

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Review Immunology

Innate and adaptive immunity in inflammatory bowel disease

Alessandra Geremia et al.

AUTOIMMUNITY REVIEWS (2014)

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Article Gastroenterology & Hepatology

Abdominal Pain in Ulcerative Colitis

Matthew D. Coates et al.

INFLAMMATORY BOWEL DISEASES (2013)

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Review Gastroenterology & Hepatology

Pain management in patients with inflammatory bowel disease: insights for the clinician

Arvind Iyengar Srinath et al.

THERAPEUTIC ADVANCES IN GASTROENTEROLOGY (2012)

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Article Gastroenterology & Hepatology

Constitutive Activation of Epithelial TLR4 Augments Inflammatory Responses to Mucosal Injury and Drives Colitis-associated Tumorigenesis

Masayuki Fukata et al.

INFLAMMATORY BOWEL DISEASES (2011)

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Article Gastroenterology & Hepatology

Expression of Toll-like receptors in the intestinal mucosa of patients with inflammatory bowel disease

Kazuo Tanaka

Expert Review of Gastroenterology & Hepatology (2008)

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New Insights into the Mechanism of Ulva pertusa on Colitis in Mice: Modulation of the Pain and Immune System

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