Detailed Understanding of Solvent Effects for the Cationic Ring-Opening Polymerization of 2-Ethyl-2-oxazoline

Article Polymer Science

Polymeric iodophors with poly(2-ethyl-2-oxazoline) and poly (N-vinylpyrrolidone): optical, hydrodynamic, thermodynamic, and antimicrobial properties

Danelya N. Makhayeva et al.

Summary: The study found that poly(2-ethyl-2-oxazoline) has a greater ability to bind iodine compared to poly(N-vinylpyrrolidone), but the iodophors formed by these two polymers exhibit similar antimicrobial properties.

EUROPEAN POLYMER JOURNAL (2022)

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Article Chemistry, Multidisciplinary

Ultrastrong Poly(2-Oxazoline)/Poly(Acrylic Acid) Double-Network Hydrogels with Cartilage-Like Mechanical Properties

Paola A. Benitez-Duif et al.

Summary: The exceptional properties of double-network hydrogels make them suitable for mimicking complex biomaterials, such as cartilage. The stability of these hydrogels is maintained even at physiological conditions. A specific type of double-network hydrogel based on poly(2-methyl-2-oxazoline) exhibits biomechanical properties similar to cartilage and high strength.

ADVANCED FUNCTIONAL MATERIALS (2022)

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Article Pharmacology & Pharmacy

Investigation of poly(2-ethyl-2-oxazoline) as a novel extended release polymer for hot-melt extrusion paired with fused deposition modeling 3D printing

Sheng Feng et al.

Summary: This study investigates the application of poly (2-ethyl-2-oxazoline) (PEtOx) as the main matrix for the development of solid oral tablets with extended release profile using hot-melt extrusion (HME) coupled with fused deposition modeling (FDM) three-dimensional (3D) printing techniques. The results show that PEtOx-based tablets can achieve the desired extended release characteristics.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2022)

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Review Polymer Science

Polyoxazoline: A review article from polymerization to smart behaviors and biomedical applications

Saba Nemati Mahand et al.

Summary: Poly(2-oxazoline)s are innovative biomaterials with analogous or better properties compared to known counterparts. They can be synthesized in a controlled manner using cationic ring-opening polymerization and have water solubility, amphiphilicity, and relative non-toxicity, making them attractive for biomedical applications. This review highlights the synthesis, structure, and properties of polyoxazolines, as well as their potential use in tissue engineering.

EUROPEAN POLYMER JOURNAL (2022)

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Article Polymer Science

The future of poly(2-oxazoline)s

Richard Hoogenboom

Summary: Poly(2-oxazoline)s have gained significant interest in the past decade, especially in the field of biomedical applications. This perspective article discusses the emerging trends in the area of poly(2-oxazoline)s, including synthetic advances, development of high molar mass polymers, expansion of the monomer range, and development of degradable derivatives. It also highlights the use of poly(2-oxazoline)s in studying polymer properties, biomedical applications such as drug delivery and 3D scaffolds, and other applications in organic devices and polymer gel electrolytes. The article concludes with a discussion on the future vision for poly(2-oxazoline)s.

EUROPEAN POLYMER JOURNAL (2022)

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Article Chemistry, Multidisciplinary

Poly(2-oxazoline) - Ferrostatin-1 drug conjugates inhibit ferroptotic cell death

Joshua P. Morrow et al.

Summary: This study reports the synthesis and characterization of water-soluble Fer-1 poly(2-oxazoline)-drug conjugates (PDCs) for anti-ferroptosis therapy. The conjugates showed improved anti-ferroptosis activity compared to reversible linked Fer-1. This work introduces the first active Fer-1 PDCs and a highly tuneable poly(2-oxazoline)-based PDC platform for anti-ferroptosis applications.

JOURNAL OF CONTROLLED RELEASE (2022)

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Article Chemistry, Multidisciplinary

Stable amorphous solid dispersion of flubendazole with high loading via electrospinning

Jana Becelaere et al.

Summary: This work demonstrates an important advancement in improving the bioavailability of poorly water-soluble drugs through solvent electrospinning. The resulting nanofibrous amorphous solid dispersions (ASDs) show high drug loadings and long-term stability. The formulation strategy involves strong hydrogen bonds between the drug and the polymer, leading to improved drug solubility and dissolution rates.

JOURNAL OF CONTROLLED RELEASE (2022)

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Article Chemistry, Physical

The separation between solvent polarizability and solvent dipolarity: Revisiting the Kamlet-Abraham-Taft model equation

Luis Moreira et al.

Summary: Quantitative structure-property relationships were established and a new model equation mKAT was proposed to improve the interpretation of solvent effects in the heterolysis reaction of 3-bromo-3-ethylpentane.

JOURNAL OF MOLECULAR LIQUIDS (2022)

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Review Polymer Science

Poly(2-oxazoline)s as Stimuli-Responsive Materials for Biomedical Applications: Recent Developments of Polish Scientists

Aleksandra Lusina et al.

Summary: Poly(2-oxazoline)s are synthetic polymers that are obtained through cationic ring-opening polymerization of 2-oxazoline monomers. They have various advantageous properties, such as biocompatibility, stability, and high functionalization possibilities, making them widely used in biomedical applications. The development of stimuli-responsive poly(2-oxazoline)s is of great importance in personalized treatment and biomedical engineering, as they can respond to specific environmental stimuli. This review article highlights recent discoveries in this field by Polish scientists and compares them with findings reported by other renowned specialists.

POLYMERS (2022)

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Article Polymer Science

Quasiliving cationic ring-opening polymerization of 2-ethyl-2-oxazoline in benzotrifluoride, as an alternative reaction medium

Balazs Pasztoi et al.

Summary: Cationic ring-opening polymerization of EtOx in BTF and other solvents shows similar kinetics, with BTF offering the highest polymerization rates and conversions; The Arrhenius parameters indicate relatively high activation energy in BTF, but a compensation effect is observed between activation energies and frequency factors in various solvents.

POLYMER (2021)

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Review Engineering, Biomedical

Poly(2-oxazoline)- and Poly(2-oxazine)-Based Self-Assemblies, Polyplexes, and Drug Nanoformulations-An Update

Anna Zahoranova et al.

Summary: Poly(2-oxazoline)s and poly(2-oxazine)s, as two closely related families of polymers, have gained increasing attention in recent years, with significant potential in macromolecular self-assemblies and non-covalent drug delivery systems. The extensive synthetic toolbox they offer suggests a high potential for further development in the field.

ADVANCED HEALTHCARE MATERIALS (2021)

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Article Thermodynamics

Densities, heat capacities, viscosities, 1H- and 13C-NMR spectra, and solvatochromic parameters of binary mixtures of 1,3-dimethyl-1,3-diazinan-2-one (DMPU) and water

Ricardo A. L. S. Santos et al.

Summary: This study reports the changes in density, viscosity, and isobaric heat capacities of binary mixtures of DMPU and water at different temperatures. Results show that the density and viscosity of the mixtures are sensitive to trace amounts of water in the organic-rich region, while the isobaric heat capacities are not, with excess molar volumes being negative.

JOURNAL OF CHEMICAL THERMODYNAMICS (2021)

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Article Biochemistry & Molecular Biology

Bone-Adhesive Hydrogels Based on Dual Crosslinked Poly(2-oxazoline)s

Maria J. Sanchez-Fernandez et al.

Summary: The development of dual crosslinked hydrogels with tunable stiffness, ductility, and self-healing capacity for bone adhesive applications is successful. These hydrogels show superior mechanical and bone adhesive properties, making them suitable for use as bone adhesive glues.

MACROMOLECULAR BIOSCIENCE (2021)

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Review Biochemistry & Molecular Biology

Polycation-Mediated Transfection: Mechanisms of Internalization and Intracellular Trafficking

Bryn D. Monnery

Summary: Polyplex-mediated gene transfection is complex, with untargeted polyplexes not following traditional mechanisms and targeting syndecans. Endocytosis requires free polycations to disrupt cell membranes and promote polyplex escape. Polyplexes release plasmids into the nucleus from the endosome, but only a small proportion of plasmids ultimately express.

BIOMACROMOLECULES (2021)

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Article Chemistry, Multidisciplinary

The green platform molecule gamma-valerolactone - ecotoxicity, biodegradability, solvent properties, and potential applications

Florian Kerkel et al.

Summary: This paper presents toxicity and biodegradability data of GVL, as well as a detailed study on harmful solvents that could potentially be replaced by GVL and further applications of this substance based on HSP and COSMO-RS calculations. The results indicate low acute toxicity of GVL towards aquatic organisms and its potential as a green solvent. GVL was found to be similar to several highly dipolar solvents and could be of interest in various industries such as manufacturing, cleaning, and cosmetics.

GREEN CHEMISTRY (2021)

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Article Chemistry, Multidisciplinary

Poly(2-methyl-2-oxazoline) conjugates with doxorubicin: From synthesis of high drug loading water-soluble constructs to in vitro anti-cancer properties

Ondrej Sedlacek et al.

JOURNAL OF CONTROLLED RELEASE (2020)

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Article Pharmacology & Pharmacy

Polymer structure and property effects on solid dispersions with haloperidol: Poly(N-vinyl pyrrolidone) and poly(2-oxazolines) studies

Xiaoning Shan et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2020)

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Article Chemistry, Multidisciplinary

Ethyl acetate as solvent for the synthesis of poly(2-ethyl-2-oxazoline)

Maarten Vergaelen et al.

GREEN CHEMISTRY (2020)

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Article Pharmacology & Pharmacy

Comparative study of the potential of poly(2-ethyl-2-oxazoline) as carrier in the formulation of amorphous solid dispersions of poorly soluble drugs

Eline Boel et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2019)

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Article Polymer Science

Tuning drug release from polyoxazoline-drug conjugates

J. Milton Harris et al.

EUROPEAN POLYMER JOURNAL (2019)

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Article Polymer Science

Thermoresponsive hydrogels formed by poly(2-oxazoline) triblock copolymers

Bryn D. Monnery et al.

POLYMER CHEMISTRY (2019)

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Review Biochemistry & Molecular Biology

Poly(2-oxazoline) Hydrogels: State-of-the-Art and Emerging Applications

Tim R. Dargaville et al.

MACROMOLECULAR BIOSCIENCE (2018)

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Article Chemistry, Multidisciplinary

Defined High Molar Mass Poly(2-Oxazoline)s

Bryn D. Monnery et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2018)

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Review Polymer Science

The chemistry of poly(2-oxazoline)s

Bart Verbraeken et al.

EUROPEAN POLYMER JOURNAL (2017)

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Article Polymer Science

Systematic investigation of alkyl sulfonate initiators for the cationic ring-opening polymerization of 2-oxazolines revealing optimal combinations of monomers and initiators

Mathias Glassner et al.

EUROPEAN POLYMER JOURNAL (2015)

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Article Polymer Science

Synthesis of poly(2-oxazoline)s with side chain methyl ester functionalities: Detailed understanding of living copolymerization behavior of methyl ester containing monomers with 2-alkyl-2-oxazolines

P. J. M. Bouten et al.

JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY (2015)

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Article Polymer Science

Kinetic Investigations of Cu-Mediated ATRP in Aqueous Solution

Sebastian Smolne et al.

MACROMOLECULAR CHEMISTRY AND PHYSICS (2015)

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Article Polymer Science

Improved Synthesis of Linear Poly(ethylenimine) via Low-Temperature Polymerization of 2-Isopropyl-2-oxazoline in Chlorobenzene

Bryn D. Monnery et al.

MACROMOLECULES (2015)

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Article Polymer Science

Accelerated living cationic ring-opening polymerization of a methyl ester functionalized 2-oxazoline monomer

Petra J. M. Bouten et al.

POLYMER CHEMISTRY (2015)

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Article Polymer Science

Sulfolane as Common Rate Accelerating Solvent for the Cationic Ring-Opening Polymerization of 2-Oxazolines

Maarten Vergaelen et al.

ACS MACRO LETTERS (2015)

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Article Polymer Science

Fast and accurate partial hydrolysis of poly(2-ethyl-2-oxazoline) into tailored linear polyethylenimine copolymers

Victor R. de la Rosa et al.

POLYMER CHEMISTRY (2014)

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Article Nanoscience & Nanotechnology

Linear polyethylenimine produced by partial acid hydrolysis of poly(2-ethyl-2-oxazoline) for DNA and siRNA delivery in vitro

Julio C. Fernandes et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2013)

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Article Polymer Science

Solvent Effects on the Activation Rate Constant in Atom Transfer Radical Polymerization

Markus Horn et al.

MACROMOLECULES (2013)

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Review Polymer Science

How to Modulate the Chemical Structure of Polyoxazolines by Appropriate Functionalization

Brieuc Guillerm et al.

MACROMOLECULAR RAPID COMMUNICATIONS (2012)

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Article Chemistry, Physical

Self-assembly of chiral block and gradient copolymers

Meta M. Bloksma et al.

SOFT MATTER (2012)

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Article Polymer Science

Linear Polyethyleneimine: Optimized Synthesis and Characterization - On the Way to Pharmagrade Batches

Lutz Tauhardt et al.

MACROMOLECULAR CHEMISTRY AND PHYSICS (2011)

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Article Engineering, Chemical

Toward the Description and Prediction of Solvent Induced Variations in Methacrylate Propagation Rate Coefficients on the Basis of Solvatochromic Parameters

Aleksandra Jelicic et al.

MACROMOLECULAR REACTION ENGINEERING (2011)

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Article Polymer Science

On the Origin of Ionic Liquid-Induced Variations in Hydroxypropyl Methacrylate Propagation Rate Coefficients

Aleksandra Jelicic et al.

JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY (2010)

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Article Chemistry, Physical

Toward a Generalized Treatment of the Solvent Effect Based on Four Empirical Scales: Dipolarity (SdP, a New Scale), Polarizability (SP), Acidity (SA), and Basicity (SB) of the Medium

Javier Catalan

JOURNAL OF PHYSICAL CHEMISTRY B (2009)

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Article Polymer Science

Solvent Effects on ATRP of Oligo(ethylene glycol) Methacrylate. Exploring the Limits of Control

Helena Bergenudd et al.

MACROMOLECULES (2009)

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Article Polymer Science

Prediction of the Ionic Liquid Influence on Propagation Rate Coefficients in Methyl Methacrylate Radical Polymerizations Based on Kamlet-Taft Solvatochromic Parameters

Aleksandra Jelicic et al.

MACROMOLECULES (2009)

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Article Polymer Science

Thermodynamic Components of the Atom Transfer Radical Polymerization Equilibrium: Quantifying Solvent Effects

Wade A. Braunecker et al.

MACROMOLECULES (2009)

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Article Polymer Science

Influence of Ionic Liquid Structure on the Propagation Kinetics of Methyl Methacrylate

Aleksandra Jelicic et al.

MACROMOLECULES (2009)

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Article Polymer Science

Initiator effect on the cationic ring-opening copolymerization of 2-ethyl-2-oxazoline and 2-phenyl-2-oxazoline

Martin W. M. Fijten et al.

JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY (2008)

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Article Polymer Science

Acetyl halide initiator screening for the cationic ring-opening polymerization of 2-ethyl-2-oxazoline

Renzo M. Paulus et al.

MACROMOLECULAR CHEMISTRY AND PHYSICS (2008)

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Article Chemistry, Multidisciplinary

Fast and green living cationic ring opening polymerization of 2-ethyl-2-oxazoline in ionic liquids under microwave irradiation

Carlos Guerrero-Sanchez et al.

CHEMICAL COMMUNICATIONS (2006)

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Article Multidisciplinary Sciences

Full deacylation of polyethylenimine dramatically boosts its gene delivery efficiency and specificity to mouse lung

M Thomas et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

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Article Polymer Science

Novel functional initiators for oxazoline polymerization

M Einzmann et al.

JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY (2001)

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Detailed Understanding of Solvent Effects for the Cationic Ring-Opening Polymerization of 2-Ethyl-2-oxazoline

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