4.5 Article

Efficient production of bispecific antibody by FAST-Ig™ and its application to NXT007 for the treatment of hemophilia A

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Editorial Material Biotechnology & Applied Microbiology

The evolution of bispecific antibodies

Nimish Gera

EXPERT OPINION ON BIOLOGICAL THERAPY (2022)

Article Medicine, Research & Experimental

Rational selection of building blocks for the assembly of bispecific antibodies

Danyang Gong et al.

Summary: Bispecific antibodies have the potential for therapeutic intervention in complex diseases, but their correct assembly of multiple polypeptide chains is crucial for industrial-scale production. Chain Selectivity Assessment (CSA) can help in rationally selecting parental monoclonal antibodies to produce bispecific antibodies with optimal manufacturability properties, including a native preference for chain pairing and rare light chain identification for positive binding.
Article Biochemistry & Molecular Biology

Discovery of amivantamab (JNJ-61186372), a bispecific antibody targeting EGFR and MET

Joost Neijssen et al.

Summary: This study focused on developing a bispecific antibody targeting EGFR and MET pathways to overcome resistance to targeted therapies in nonsmall cell lung cancer patients. By sequentially screening a panel of BsAbs and selecting the optimal bispecific molecule, amivantamab was generated and demonstrated superior antitumor activity in preclinical models. The unique mode of action of amivantamab may provide benefits to patients with malignancies associated with aberrant EGFR and MET signaling.

JOURNAL OF BIOLOGICAL CHEMISTRY (2021)

Review Immunology

Bispecific Antibodies: From Research to Clinical Application

Jiabing Ma et al.

Summary: Bispecific antibodies (BsAbs) have two binding sites directed at different antigens or epitopes, and their clinical therapeutic effects are superior to monoclonal antibodies (MoAbs), used in tumor immunotherapy and other disease treatments. Over 30 mature commercial technology platforms have been utilized to generate and develop BsAbs based on heterologous recombination of heavy chains and light chains, with three BsAbs receiving market approval.

FRONTIERS IN IMMUNOLOGY (2021)

Review Medicine, Research & Experimental

The state of the art of bispecific antibodies for treating human malignancies

Shuhang Wang et al.

Summary: Bispecific antibodies targeting two independent epitopes or antigens have been extensively explored in translational and clinical studies since the 1960s, with many currently being tested in clinical trials for cancer treatment. This overview discusses the targets, safety profiles, and efficacy of various types of bsAbs in clinical studies, highlighting current challenges, potential solutions, and future directions for their development in cancer treatment.

EMBO MOLECULAR MEDICINE (2021)

Article Hematology

Low immunogenicity of emicizumab in persons with haemophilia A

Christophe Schmitt et al.

Summary: Emicizumab has low immunogenicity risk in phase 3 studies, and antibodies, including neutralising antibodies, did not affect its safety profile. Routine surveillance is not necessary, but prompt evaluation by healthcare providers is recommended in cases of efficacy decline.

HAEMOPHILIA (2021)

Review Oncology

T cell-engaging therapies - BiTEs and beyond

Maria-Elisabeth Goebeler et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2020)

Article Medicine, Research & Experimental

Intein mediated high throughput screening for bispecific antibodies

Tim Hofmann et al.

Review Biotechnology & Applied Microbiology

Bispecific antibodies: a mechanistic review of the pipeline

Aran F. Labrijn et al.

NATURE REVIEWS DRUG DISCOVERY (2019)

Review Chemistry, Multidisciplinary

Electrostatic Interactions in Protein Structure, Folding, Binding, and Condensation

Huan-Xiang Zhou et al.

CHEMICAL REVIEWS (2018)

Article Biochemistry & Molecular Biology

Variable heavy-variable light domain and Fab-arm CrossMabs with charged residue exchanges to enforce correct light chain assembly

Joerg Thomas Regula et al.

PROTEIN ENGINEERING DESIGN & SELECTION (2018)

Article Pharmacology & Pharmacy

The effect of charge mutations on the stability and aggregation of a human single chain Fv fragment

James I. Austerberry et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2017)

Article Biochemistry & Molecular Biology

Immunoglobulin domain interface exchange as a platform technology for the generation of Fc heterodimers and bispecific antibodies

Darko Skegro et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2017)

Review Medicine, Research & Experimental

The making of bispecific antibodies

Ulrich Brinkmann et al.

Article Medicine, General & Internal

Emicizumab Prophylaxis in Hemophilia A with Inhibitors

Johannes Oldenburg et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

Article Biochemistry & Molecular Biology

Generation of human bispecific common light chain antibodies by combining animal immunization and yeast display

Simon Krah et al.

PROTEIN ENGINEERING DESIGN & SELECTION (2017)

Article Cell Biology

An anti-glypican 3/CD3 bispecific T cell-redirecting antibody for treatment of solid tumors

Takahiro Ishiguro et al.

SCIENCE TRANSLATIONAL MEDICINE (2017)

Review Biotechnology & Applied Microbiology

Advances in recombinant antibody manufacturing

Renate Kunert et al.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2016)

Article Biochemical Research Methods

Protein A chromatography increases monoclonal antibody aggregation rate during subsequent low pH virus inactivation hold

Alice R. Mazzer et al.

JOURNAL OF CHROMATOGRAPHY A (2015)

Article Medicine, Research & Experimental

Improving target cell specificity using a novel monovalent bispecific IgG design

Yariv Mazor et al.

Article Medicine, Research & Experimental

Lysine and Arginine Content of Proteins: Computational Analysis Suggests a New Tool for Solubility Design

Jim Warwicker et al.

MOLECULAR PHARMACEUTICS (2014)

Article Biotechnology & Applied Microbiology

Generation of bispecific IgG antibodies by structure-based design of an orthogonal Fab interface

Steven M. Lewis et al.

NATURE BIOTECHNOLOGY (2014)

Article Biochemistry & Molecular Biology

Conformational Selection in Substrate Recognition by Hsp70 Chaperones

Moritz Marcinowski et al.

JOURNAL OF MOLECULAR BIOLOGY (2013)

Article Biotechnology & Applied Microbiology

Bispecific antibodies with natural architecture produced by co-culture of bacteria expressing two distinct half-antibodies

Christoph Spiess et al.

NATURE BIOTECHNOLOGY (2013)

Article Multidisciplinary Sciences

Efficient generation of stable bispecific IgG1 by controlled Fab-arm exchange

Aran F. Labrijn et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Pharmacology & Pharmacy

Beyond humanization and de-immunization: tolerization as a method for reducing the immunogenicity of biologics

Anne S. De Groot et al.

EXPERT REVIEW OF CLINICAL PHARMACOLOGY (2013)

Article Biochemistry & Molecular Biology

Elucidation of Acid-induced Unfolding and Aggregation of Human Immunoglobulin IgG1 and IgG2 Fc

Ramil F. Latypov et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

Article Biochemistry & Molecular Biology

A bispecific antibody to factors IXa and X restores factor VIII hemostatic activity in a hemophilia A model

Takehisa Kitazawa et al.

NATURE MEDICINE (2012)

Review Medicine, Research & Experimental

Engineering the variable region of therapeutic IgG antibodies

Tomoyuki Igawa et al.

Article Multidisciplinary Sciences

Immunoglobulin domain crossover as a generic approach for the production of bispecific IgG antibodies

Wolfgang Schaefer et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Article Biochemistry & Molecular Biology

Enhancing Antibody Fc Heterodimer Formation through Electrostatic Steering Effects APPLICATIONS TO BISPECIFIC MOLECULES AND MONOVALENT IgG

Kannan Gunasekaran et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Article Biochemistry & Molecular Biology

Stability engineering of scFvs for the development of bispecific and multivalent antibodies

Brian R. Miller et al.

PROTEIN ENGINEERING DESIGN & SELECTION (2010)

Review Biochemistry & Molecular Biology

How antibodies fold

Matthias J. Feige et al.

TRENDS IN BIOCHEMICAL SCIENCES (2010)

Article Biochemistry & Molecular Biology

An Unfolded CH1 Domain Controls the Assembly and Secretion of IgG Antibodies

Matthias J. Feige et al.

MOLECULAR CELL (2009)

Article Medicine, Research & Experimental

Anti-tumor activity of stability-engineered IgG-like bispecific antibodies targeting TRAIL-R2 and LTβR

Jennifer S. Michaelson et al.

Review Pharmacology & Pharmacy

Prediction of immunogenicity: in silico paradigms, ex vivo and in vivo correlates

Anne S. De Groot et al.

CURRENT OPINION IN PHARMACOLOGY (2008)

Review Chemistry, Multidisciplinary

Extrinsic fluorescent dyes as tools for protein characterization

Andrea Hawe et al.

PHARMACEUTICAL RESEARCH (2008)