☆ 4.5 Article

Development of a portable abdominal normothermic regional perfusion (A-NRP) program in the United States

LIVER TRANSPLANTATION (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Review Medicine, General & Internal

Introducing Machine Perfusion into Routine Clinical Practice for Liver Transplantation in the United States: The Moment Has Finally Come

Kristopher P. Croome

Summary: While the adoption of machine perfusion technologies in clinical practice has been slow in the United States compared to Europe, recent changes in the transplant field and FDA approval for devices have opened the way for rapid growth. Machine perfusion offers a means to maximize the utilization of potential donor liver grafts. Studies have shown increased organ utilization through the implementation of ex-situ normothermic machine perfusion (NMP), ex-situ hypothermic machine perfusion (HMP), and in-situ normothermic regional perfusion (NRP). This review discusses the history, development, and future directions of machine perfusion utilization in the United States, as well as the differences between Europe and the United States and how they have influenced the clinical application of these technologies.

JOURNAL OF CLINICAL MEDICINE (2023)

添加到收藏夹

Article Immunology

Improved Organ Utilization and Better Transplant Outcomes With In Situ Normothermic Regional Perfusion in Controlled Donation After Circulatory Death

Gabriel C. Oniscu et al.

Summary: The use of normothermic regional perfusion (NRP) during controlled donation after circulatory death (cDCD) is associated with increased organ recovery and improved transplant outcomes.

TRANSPLANTATION (2023)

添加到收藏夹

Review Surgery

American Society of Transplant Surgeons recommendations on best practices in donation after circulatory death organ procurement

Kristopher P. Croome et al.

Summary: The American Society of Transplant Surgeons supports increasing organ availability for transplantation. Variability in the utilization and practices of donation after circulatory death (DCD) transplantation exists. To improve DCD organ utilization, a work group has proposed recommendations on controversial or lacking standardized topics in DCD procurement.

AMERICAN JOURNAL OF TRANSPLANTATION (2023)

添加到收藏夹

Article Surgery

Abdominal normothermic regional perfusion in controlled donation after circulatory determination of death liver transplantation: Outcomes and risk factors for graft loss

Amelia J. Hessheimer et al.

Summary: The study shows the benefits of using A-NRP over SRR in cDCD liver transplants in Spain, with reduced risks of overall biliary complications, ischemic type biliary lesions, graft loss, and patient death. Cold ischemia time and re-transplantation indication are significant independent predictors for graft loss in cDCD livers with A-NRP. Further improvements are needed for cases with prolonged cold ischemia and technically complex recipients, suggesting a potential role for complementary ex situ perfusion preservation techniques.

AMERICAN JOURNAL OF TRANSPLANTATION (2022)

添加到收藏夹

Editorial Material Surgery

Normothermic regional perfusion and US legal standards for determining death are not aligned

Alexandra K. Glazier et al.

AMERICAN JOURNAL OF TRANSPLANTATION (2022)

添加到收藏夹

Article Gastroenterology & Hepatology

The Current Landscape of Liver Transplantation After Ex Situ Machine Perfusion and Normothermic Regional Perfusion in the United States

Kristopher P. Croome et al.

LIVER TRANSPLANTATION (2022)

添加到收藏夹

Article Surgery

Liver Transplantation Outcomes From Controlled Circulatory Death Donors SCS vs in situ NRP vs ex situ NMP

Rohit Gaurav et al.

Summary: NRP and NMP were associated with better early liver function compared to SCS, whereas NRP was associated with superior preservation of the biliary system.

ANNALS OF SURGERY (2022)

添加到收藏夹

Article Surgery

Early United States experience with liver donation after circulatory determination of death using thoraco-abdominal normothermic regional perfusion: A multi-institutional observational study

Marty T. Sellers et al.

Summary: This study retrospectively reviewed the outcomes of the first 13 liver transplants using thoraco-abdominal normothermic perfusion (TA-NRP) in donation after circulatory determination of death (DCD) donors in the US. The results showed that the majority of recipients had good liver function during the post-transplant period, indicating that TA-NRP could decrease deaths on the waiting list.

CLINICAL TRANSPLANTATION (2022)

添加到收藏夹

Article Immunology

Classification of Distinct Patterns of Ischemic Cholangiopathy Following DCD Liver Transplantation: Distinct Clinical Courses and Long-term Outcomes From a Multicenter Cohort

Kristopher P. Croome et al.

Summary: This study provides a detailed analysis of the natural history and clinical course of IC, showing that IC can be classified into 4 distinct patterns with different clinical courses.

TRANSPLANTATION (2022)

添加到收藏夹

Article Surgery

From Haphazard to a Sustainable Normothermic Regional Perfusion Service: A Blueprint for the Introduction of Novel Perfusion Technologies

Fiona Hunt et al.

Summary: This article describes a model for the implementation of Normothermic Regional Perfusion (NRP) into standard clinical practice. The model involved iterative refinement incorporating training, staffing, and operative techniques. The results showed successful implementation of NRP throughout the UK and a significant increase in organ transplantation. In addition, the model enabled the implementation of ex situ normothermic liver perfusion, contributing to a significant portion of liver transplant activity in 2021.

TRANSPLANT INTERNATIONAL (2022)

添加到收藏夹

Article Immunology

Regulations and Procurement Surgery in DCD Liver Transplantation: Expert Consensus Guidance From the International Liver Transplantation Society

Amelia J. Hessheimer et al.

Summary: The working group of the International Liver Transplantation Society evaluated current evidence and combined experience to create guidance on DCD liver procurement, including best practices and the use of adjuncts. Events during DCD liver recovery have a significant impact on the success of subsequent transplantation.

TRANSPLANTATION (2021)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Early US experience with cardiac donation after circulatory death (DCD) using normothermic regional perfusion

Jordan R. H. Hoffman et al.

Summary: This study conducted heart transplantations using DCD allografts, extending cold ischemic time with TA-NRP and cold static storage, which improved the feasibility and success rate of heart transplantation.

JOURNAL OF HEART AND LUNG TRANSPLANTATION (2021)

添加到收藏夹

Article Gastroenterology & Hepatology

Intraoperative Events in Liver Transplantation Using Donation After Circulatory Death Donors

Ryan M. Chadha et al.

LIVER TRANSPLANTATION (2019)

添加到收藏夹

Article Surgery

In situ normothermic perfusion of livers in controlled circulatory death donation may prevent ischemic cholangiopathy and improve graft survival

Christopher J. E. Watson et al.

AMERICAN JOURNAL OF TRANSPLANTATION (2019)

添加到收藏夹

Article Immunology

Donation After Circulatory Determination of Death: The University of Michigan Experience With Extracorporeal Support

Alvaro Rojas-Pena et al.

TRANSPLANTATION (2014)

添加到收藏夹

Article Gastroenterology & Hepatology

Evaluation of the updated definition of early allograft dysfunction in donation after brain death and donation after cardiac death liver allografts

Kris P. Croome et al.

HEPATOBILIARY & PANCREATIC DISEASES INTERNATIONAL (2012)

添加到收藏夹

Article Gastroenterology & Hepatology

Validation of a Current Definition of Early Allograft Dysfunction in Liver Transplant Recipients and Analysis of Risk Factors

Kim M. Olthoff et al.

LIVER TRANSPLANTATION (2010)

添加到收藏夹

Article Critical Care Medicine

Extracorporeal support for organ donation after cardiac death effectively expands the donor pool

JF Magliocca et al.

JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE (2005)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.