Fluorescence confocal microscopy on liver specimens: Could it be a game changer in transplantation pathology?

Article Oncology

Ex Vivo Fluorescence Confocal Microscopy in Specimens of the Liver: A Proof-of-Concept Study

Ulf Titze et al.

Summary: Fluorescence confocal microscopy is a novel micro-imaging technique that provides optical sections of native tissue. This study compares the findings of FCM examinations of liver tissue with conventional histology, and finds that FCM is highly suitable for tumor diagnosis and moderately to good for inflammation assessment.

CANCERS (2022)

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Article Pathology

Validation of portable tablets for transplant pathology diagnosis according to the College of American Pathologists' Guidelines

Stefano Marletta et al.

Summary: This study demonstrates the non-inferiority of whole slide imaging (WSI) compared to light microscopy (LM) for intraoperative transplantation diagnosis, supporting the use of digital tools for remote diagnostic work in the transplantation setting.

ACADEMIC PATHOLOGY (2022)

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Article Gastroenterology & Hepatology

Donor-Transmitted Cancers in Transplanted Livers: Analysis of Clinical Outcomes

Albino Eccher et al.

Summary: The risk of transmission of malignancy from donor to recipient is low but has dramatic consequences, mainly with lymphomas, melanomas, and neuroendocrine tumors. Melanoma recipients have the worst prognosis, while lymphoma recipients have over 75% survival at 2 years.

LIVER TRANSPLANTATION (2021)

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Article Oncology

Digital Biopsy with Fluorescence Confocal Microscope for Effective Real-time Diagnosis of Prostate Cancer: A Prospective, Comparative Study

Bernardo Rocco et al.

Summary: This study evaluated the diagnostic ability of fluorescence confocal microscopy (FCM) for prostate cancer (PCa) identification and grading, showing that FCM is almost perfectly aligned with HE in PCa detection. Inter-rater agreement among pathologists was almost perfect for PCa detection, but only reached a moderate level for cancer grading.

EUROPEAN UROLOGY ONCOLOGY (2021)

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Article Urology & Nephrology