Postoperative fibrinolytic resistance is associated with early allograft dysfunction in liver transplantation: A prospective observational study

Perioperative dysfunction of the fibrinolytic system may play a role in adverse outcomes for liver transplant recipients. There is a paucity of data describing the potential impact of the postoperative fibrinolytic system on these outcomes. Our objective was to determine whether fibrinolysis resistance (FR), on postoperative day one (POD-1), was associated with early allograft dysfunction (EAD). We hypothesized that FR, quantified by tissue plasminogen activator thrombelastography, is associated with EAD. Tissue plasminogen activator thrombelastography was performed on POD-1 for 184 liver transplant recipients at a single institution. A tissue plasminogen activator thrombelastography clot lysis at 30 minutes of 0.0% was identified as the cutoff for FR on POD-1. EAD occurred in 32% of the total population. Fifty-nine percent (n=108) of patients were categorized with FR. The rate of EAD was 42% versus 17%, p<0.001 in patients with FR compared with those without, respectively. The association between FR and EAD risk was assessed using multivariable logistic regression after controlling for known risk factors. The odds of having EAD were 2.43 times (95% CI, 1.07-5.50, p=0.03) higher in recipients with FR [model C statistic: 0.76 (95% CI, 0.64-0.83, p<0.001]. An additive effect of receiving a donation after circulatory determination of death graft and having FR in the rate of EAD was observed. Finally, compared with those without FR, recipients with FR had significantly shorter graft survival time (p=0.03). In conclusion, FR on POD-1 is associated with EAD and decreased graft survival time. Postoperative viscoelastic testing may provide clinical utility in identifying patients at risk for developing EAD, especially for recipients receiving donation after circulatory determination of death grafts.

Automated summary

Perioperative dysfunction of the fibrinolytic system may contribute to adverse outcomes in liver transplant recipients. This study examined the association between fibrinolysis resistance (FR), measured by tissue plasminogen activator thrombelastography on postoperative day one, and early allograft dysfunction (EAD). The results showed that FR on POD-1 was significantly associated with increased risk of EAD and decreased graft survival time. This suggests that postoperative viscoelastic testing could be a useful tool in identifying liver transplant recipients at risk for EAD, particularly in those receiving donation after circulatory determination of death grafts.