☆ 4.7 Article

Mitochondrion: A bridge linking aging and degenerative diseases

LIFE SCIENCES (2023)

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Weizhou Jiang et al.

Summary: Mechanical loading is crucial for chondrocyte health, with mitochondria playing a critical role as mechanotransducers. Research has focused on the link between mechanical loading-induced mitochondrial dysfunction and the pathogenesis of osteoarthritis. There is a need for further investigation into the mechanisms behind mitochondrial functional alterations induced by mechanical stimulation.

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Role of Mitochondria in Physiology of Chondrocytes and Diseases of Osteoarthritis and Rheumatoid Arthritis

Shiyi Kan et al.

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Mefunidone Ameliorates Bleomycin-Induced Pulmonary Fibrosis in Mice

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FRONTIERS IN PHARMACOLOGY (2021)

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Article Biochemistry & Molecular Biology

The mitochondria-targeted antioxidant MitoQ attenuated PM2.5-induced vascular fibrosis via regulating mitophagy

Ruihong Ning et al.

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Emerging Antioxidant Paradigm of Mesenchymal Stem Cell-Derived Exosome Therapy

Chen Xia et al.

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FRONTIERS IN ENDOCRINOLOGY (2021)

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Article Biochemistry & Molecular Biology

SIRT3 ameliorates osteoarthritis via regulating chondrocyte autophagy and apoptosis through the PI3K/Akt/mTOR pathway

Kai Xu et al.

Summary: This study investigated the role of SIRT3 in osteoarthritis pathophysiology and found that SIRT3 serves as a protective agent against OA by inhibiting the PI3K/Akt/mTOR signaling pathway.

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Article Biochemistry & Molecular Biology

A Highly Selective In Vitro JNK3 Inhibitor, FMU200, Restores Mitochondrial Membrane Potential and Reduces Oxidative Stress and Apoptosis in SH-SY5Y Cells

Stephanie Cristine Hepp Rehfeldt et al.

Summary: Current treatments for neurodegenerative diseases are limited in slowing down disease progression. This research evaluates the neuroprotective, anti-inflammatory, and antioxidant effects of a synthetic compound with JNK3 inhibitory activity in neuroblastoma cells, showing promising results in reducing cell damage and inflammation. This compound could be a potential candidate for treating neurodegenerative disorders.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Immunology

Hallmarks of T cell aging

Maria Mittelbrunn et al.

Summary: In this Review, Mittelbrunn and Kroemer propose ten molecular hallmarks as common denominators of T cell aging, which include primary and secondary hallmarks explaining the manifestation of T cell aging and its impact on overall deterioration. The challenge now is to weigh the relative impact of these hallmarks on T cell aging and understand their interconnections, with the goal of defining molecular targets for interventions in the aging process.

NATURE IMMUNOLOGY (2021)

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Article Cell Biology

Urolithin A improves muscle function by inducing mitophagy in muscular dystrophy

Peiling Luan et al.

Summary: Research shows that decreased mitochondrial autophagy may contribute to mitochondrial dysfunction in Duchenne muscular dystrophy (DMD) patients and experimental models. However, administration of the mitophagy activator urolithin A can improve mitochondrial function and alleviate symptoms of DMD, suggesting potential therapeutic applications for muscular dystrophies.

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Dietary spermidine improves cognitive function

Sabrina Schroeder et al.

Summary: Dietary spermidine has been shown to enhance cognition by affecting mitochondrial and autophagic function in aged mice and fruit flies. These findings suggest the potential role of dietary spermidine in improving cognitive function.

CELL REPORTS (2021)

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Article Biochemistry & Molecular Biology

Sirt3-mediated mitophagy regulates AGEs-induced BMSCs senescence and senile osteoporosis

Yuanyuan Guo et al.

Summary: Senile osteoporosis (SOP) is a typical aging-related disease characterized by a decrease in bone mass. Sirt3 plays a protective role against AGEs-induced BMSCs senescence and SOP by improving mitophagy, suggesting it as a potential therapeutic target for AGEs-associated SOP.

REDOX BIOLOGY (2021)

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Article Medicine, General & Internal

Alzheimer disease

David S. Knopman et al.

Summary: Alzheimer's disease is a neurodegenerative disorder characterized by cognitive impairments. The pathophysiology involves a complex interplay of loss of synaptic homeostasis and dysfunction in endosomal/lysosomal clearance pathways. Therapeutic options are still being sought to substantially alter the clinical course of individuals with Alzheimer's disease.

NATURE REVIEWS DISEASE PRIMERS (2021)

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Article Biotechnology & Applied Microbiology

Senolytic Peptide FOXO4-DRI Selectively Removes Senescent Cells From in vitro Expanded Human Chondrocytes

Yuzhao Huang et al.

Summary: ACI is a procedure used to treat articular cartilage injuries, and in vitro expansion of chondrocytes for ACI can result in the generation of senescent cells. FOXO4-DRI has been shown to selectively kill senescent fibroblasts, and in this study, it was found to reduce senescence in expanded chondrocytes. However, further investigation is needed to determine its potential in promoting cartilage formation.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2021)

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Editorial Material Cell Biology

Spermidine-induced hypusination preserves mitochondrial and cognitive function during aging

Sebastian J. Hofer et al.

Summary: Spermidine is a natural polyamine that plays a central role in promoting cellular autophagy, prolonging lifespan, and improving mitochondrial function. Dietary supplementation of spermidine enhances the hypusination of protein eEF5/EIF5A, boosts cerebral mitochondrial function and cognition.

AUTOPHAGY (2021)

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Article Cell Biology

Distinct properties of Ca2+ efflux from brain, heart and liver mitochondria: The effects of Na+, Li+ and the mitochondrial Na+/Ca2+ exchange inhibitor CGP37157

Jacob E. Rysted et al.

Summary: Mitochondrial Ca2+ extrusion via Na+/Ca2+/Li+ exchanger (NCLX) differs among tissues, with higher expression in the liver. Na+ activates Ca2+ efflux in brain and heart mitochondria, while Li+ slows down the process. This suggests that mtNCX plays a major role in brain and heart mitochondria but has minimal effect in liver mitochondria. Li+ is less effective than Na+ in driving mitochondrial Ca2+ efflux.

CELL CALCIUM (2021)

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Review Biochemistry & Molecular Biology

Mitochondrial fusion and fission: The fine-tune balance for cellular homeostasis

Mary Adebayo et al.

Summary: Mitochondria are dynamic organelles inherited maternally, fulfilling cellular energy demand and playing roles in cell signaling, metabolism, and apoptosis. Maintenance of mitochondrial integrity and homeostasis through fusion and fission is crucial, and imbalance can lead to various diseases.

FASEB JOURNAL (2021)

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Review Biochemistry & Molecular Biology

Mitochondrial Dynamics and Mitophagy in Skeletal Muscle Health and Aging

Jean-Philippe Leduc-Gaudet et al.

Summary: The maintenance of mitochondrial integrity is crucial for muscle health, with dysfunctional mitochondrial dynamics and mitophagy potentially contributing to sarcopenia. Enhancing mitophagy in skeletal muscle may be a promising therapeutic target to prevent or treat skeletal muscle dysfunction in the elderly.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Biochemistry & Molecular Biology

Impact of the Natural Compound Urolithin A on Health, Disease, and Aging

Davide D'Amico et al.

Summary: Urolithin A is a natural compound derived from gut bacteria, with benefits such as enhancing cellular health and reducing inflammation. Preclinical studies have shown that UA plays a crucial role in protecting muscles, brain, joints, and other organs from aging and age-related conditions.

TRENDS IN MOLECULAR MEDICINE (2021)

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Article Multidisciplinary Sciences

Impact of aging and exercise on skeletal muscle mitochondrial capacity, energy metabolism, and physical function

L. Grevendonk et al.

Summary: The decline in mitochondrial function and muscle health associated with aging can be partially offset by increasing physical activity levels through regular exercise training. Maintenance of adequate physical activity levels does not entirely prevent age-associated deterioration of skeletal muscle. Mitochondrial capacity is correlated with exercise efficiency and insulin sensitivity.

NATURE COMMUNICATIONS (2021)

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Review Cell Biology

Autophagy in healthy aging and disease

Yahyah Aman et al.

Summary: This Review discusses the recent research on the mechanisms and roles of autophagy in health, aging, and disease, and how drugs modulating autophagy process could be used to suppress age-associated diseases. It examines emerging features of autophagy and proposes the potential links to aging and disease progression. The review also highlights the importance of understanding the interplay between autophagy and age-related pathologies for the development of clinical applications promoting long-term health.

NATURE AGING (2021)

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Article Biochemistry & Molecular Biology

Mitocytosis, a migrasome-mediated mitochondrial quality-control process

Haifeng Jiao et al.

Summary: Mitocytosis is a migrasome-mediated mitochondrial quality-control process that helps maintain mitochondrial quality in migrating cells. The process involves positioning damaged mitochondria at the cell periphery, which avoids binding to inward motor proteins. Enhanced mitocytosis protects cells from mitochondrial stressor-induced loss of mitochondrial membrane potential and mitochondrial respiration, while blocking mitocytosis causes loss of these functions under normal conditions. Physiologically, mitocytosis is required for maintaining mitochondrial membrane potential and viability in neutrophils in vivo.

CELL (2021)

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Review Physiology

Physiological regulation of reactive oxygen species in organisms based on their physicochemical properties

Mei-Zhou Huang et al.

ACTA PHYSIOLOGICA (2020)

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Article Biochemistry & Molecular Biology

LRRK2 regulates endoplasmic reticulum-mitochondrial tethering through the PERK-mediated ubiquitination pathway

Toshihiko Toyofuku et al.

EMBO JOURNAL (2020)

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Article Biochemistry & Molecular Biology

Adenosine A2A receptor (A2AR) stimulation enhances mitochondrial metabolism and mitigates reactive oxygen species-mediated mitochondrial injury

Cristina M. Castro et al.

FASEB JOURNAL (2020)

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Article Cell Biology

Mitochondria-to-nucleus retrograde signaling drives formation of cytoplasmic chromatin and inflammation in senescence

Maria Grazia Vizioli et al.

GENES & DEVELOPMENT (2020)

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Article Biochemistry & Molecular Biology

Visualizing and Modulating Mitophagy for Therapeutic Studies of Neurodegeneration

Hiroyuki Katayama et al.

CELL (2020)

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Article Cell Biology

Metformin Enhances Autophagy and Normalizes Mitochondrial Function to Alleviate Aging-Associated Inflammation

Leena P. Bharath et al.

CELL METABOLISM (2020)

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Article Multidisciplinary Sciences

Moderation of mitochondrial respiration mitigates metabolic syndrome of aging

Mojdeh S. Tavallaie et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

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Article Multidisciplinary Sciences

Increased mitochondrial calcium levels associated with neuronal death in a mouse model of Alzheimer's disease

Maria Calvo-Rodriguez et al.

NATURE COMMUNICATIONS (2020)

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Article Multidisciplinary Sciences

Mitochondrial phosphatase PGAM5 modulates cellular senescence by regulating mitochondrial dynamics

Bo Yu et al.

NATURE COMMUNICATIONS (2020)

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Review Cell Biology

Reactive oxygen species (ROS) as pleiotropic physiological signalling agents

Helmut Sies et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)

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Article Orthopedics

MFN2 contributes to metabolic disorders and inflammation in the aging of rat chondrocytes and osteoarthritis

L. Xu et al.

OSTEOARTHRITIS AND CARTILAGE (2020)

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Article Engineering, Biomedical

MSC-derived exosomes protect against oxidative stress-induced skin injury via adaptive regulation of the NRF2 defense system

Tian Wang et al.

BIOMATERIALS (2020)

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Review Biotechnology & Applied Microbiology

Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing

Stephen C. Cunnane et al.

NATURE REVIEWS DRUG DISCOVERY (2020)

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Article Cell Biology

Stabilization of HIF-1α alleviates osteoarthritis via enhancing mitophagy

Sunli Hu et al.

CELL DEATH & DISEASE (2020)

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Article Physiology

Berberine Promotes Cardiac Function by Upregulating PINK1/Parkin-Mediated Mitophagy in Heart Failure

Miyesaier Abudureyimu et al.

FRONTIERS IN PHYSIOLOGY (2020)

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Article Cell Biology

Updating the Free Radical Theory of Aging

Adam S. Ziada et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

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Article Cardiac & Cardiovascular Systems

Reduced reticulum-mitochondria Ca2+ transfer is an early and reversible trigger of mitochondrial dysfunctions in diabetic cardiomyopathy

Maya Dia et al.

BASIC RESEARCH IN CARDIOLOGY (2020)

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Review Cell Biology

Senescence and the SASP: many therapeutic avenues

Jodie Birch et al.

GENES & DEVELOPMENT (2020)

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Review Medicine, Research & Experimental

Role of mitochondria in mediating chondrocyte response to mechanical stimuli

Yuchen He et al.

LIFE SCIENCES (2020)

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Article Multidisciplinary Sciences

Targeted exosome coating gene-chem nanocomplex as nanoscavenger for clearing α-synuclein and immune activation of Parkinson's disease

Linying Liu et al.

SCIENCE ADVANCES (2020)

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Article Multidisciplinary Sciences

Pharmacological targeting of MCL-1 promotes mitophagy and improves disease pathologies in an Alzheimer's disease mouse model

Xufeng Cen et al.

NATURE COMMUNICATIONS (2020)

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Review Cell Biology

Cellular Mechanisms and Regulation of Quiescence

Oceane Marescal et al.

DEVELOPMENTAL CELL (2020)

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Review Biochemistry & Molecular Biology

Reactive oxygen species, aging and articular cartilage homeostasis

Jesalyn A. Bolduc et al.

FREE RADICAL BIOLOGY AND MEDICINE (2019)

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Article Biochemistry & Molecular Biology

The free radical theory of frailty: Mechanisms and opportunities for interventions to promote successful aging

Jose Vina

FREE RADICAL BIOLOGY AND MEDICINE (2019)

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Article Neurosciences

Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer's disease

Evandro F. Fang et al.

NATURE NEUROSCIENCE (2019)

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Article Multidisciplinary Sciences

Sodium rutin ameliorates Alzheimer's disease-like pathology by enhancing microglial amyloid-β clearance

Rui-Yuan Pan et al.

SCIENCE ADVANCES (2019)

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Review Biophysics

Role of DJ-1 in the mechanism of pathogenesis of Parkinson's disease

Ludmila P. Dolgacheva et al.

JOURNAL OF BIOENERGETICS AND BIOMEMBRANES (2019)

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Review Medicine, Research & Experimental

Parkinson's disease: Mechanisms, translational models and management strategies

Chand Raza et al.

LIFE SCIENCES (2019)

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Review Cell Biology

Mitochondrial Homeostasis and Cellular Senescence

Panagiotis V. S. Vasileiou et al.

CELLS (2019)

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Article Genetics & Heredity

The Microbiome and Aging

Bianca Bana et al.

Annual Review of Genetics (2019)

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Review Medical Laboratory Technology

Hallmarks of senescence and aging

Slavica Dodig et al.

BIOCHEMIA MEDICA (2019)

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Review Clinical Neurology

Ageing as a risk factor for neurodegenerative disease

Yujun Hou et al.

NATURE REVIEWS NEUROLOGY (2019)

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Article Physiology

Aging and Lung Disease

Soo Jung Cho et al.

Annual Review of Physiology (2019)

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Review Biochemistry & Molecular Biology

Causal roles of mitochondrial dynamics in longevity and healthy aging

Arpit Sharma et al.

EMBO REPORTS (2019)

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Review Cell Biology

Mitophagy, Mitochondrial Dynamics, and Homeostasis in Cardiovascular Aging

Ne N. Wu et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2019)

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Article Cell Biology

Mitochondrial Oxidative Stress Impairs Energy Metabolism and Reduces Stress Resistance and Longevity of C. elegans

Benjamin Dilberger et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2019)

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Review Cell Biology

Astaxanthin: A Potential Mitochondrial-Targeted Antioxidant Treatment in Diseases and with Aging

Monika Sztretye et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2019)

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Article Multidisciplinary Sciences

Advanced Glycation End-Products Suppress Mitochondrial Function and Proliferative Capacity of Achilles Tendon-Derived Fibroblasts

Shivam H. Patel et al.

SCIENTIFIC REPORTS (2019)

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Article Biology

Elevating acetyl-CoA levels reduces aspects of brain aging

Antonio Currais et al.

ELIFE (2019)

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Article Neurosciences

ASCs-Exosomes Recover Coupling Efficiency and Mitochondrial Membrane Potential in an in vitro Model of ALS

Elisa Calabria et al.

FRONTIERS IN NEUROSCIENCE (2019)

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Article Medicine, General & Internal

Pink1-Mediated Chondrocytic Mitophagy Contributes to Cartilage Degeneration in Osteoarthritis

Hyo Jung Shin et al.

JOURNAL OF CLINICAL MEDICINE (2019)

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Review Medicine, Research & Experimental

Mitochondria, OxPhos, and neurodegeneration: cells are not just running out of gas

Estela Area-Gomez et al.

JOURNAL OF CLINICAL INVESTIGATION (2019)

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Article Chemistry, Multidisciplinary

Chiral Molecule-mediated Porous CuxO Nanoparticle Clusters with Antioxidation Activity for Ameliorating Parkinson's Disease

Changlong Hao et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2019)

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Article Biotechnology & Applied Microbiology

Primary chondrocyte exosomes mediate osteoarthritis progression by regulating mitochondrion and immune reactivity

Lin Zheng et al.

NANOMEDICINE (2019)

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Article Biochemistry & Molecular Biology

Enhanced inter-compartmental Ca2+ flux modulates mitochondrial metabolism and apoptotic threshold during aging

Corina T. Madreiter-Sokolowski et al.

REDOX BIOLOGY (2019)

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Article Clinical Neurology

Alpha-synuclein suppresses mitochondrial protease ClpP to trigger mitochondrial oxidative damage and neurotoxicity

Di Hu et al.

ACTA NEUROPATHOLOGICA (2019)

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Review Biochemistry & Molecular Biology

Metabolic Intermediates in Tumorigenesis and Progression

Yuchen He et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2019)

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Article Chemistry, Multidisciplinary

Tau-Targeted Multifunctional Nanocomposite for Combinational Therapy of Alzheimer's Disease

Ling Chen et al.

ACS NANO (2018)

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Article Clinical Neurology

Alpha-synuclein delays mitophagy and targeting Miro rescues neuron loss in Parkinson's models

Atossa Shaltouki et al.

ACTA NEUROPATHOLOGICA (2018)

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Article Cell Biology

Monoamine oxidase-A is a novel driver of stress-induced premature senescence through inhibition of parkin-mediated mitophagy

Nicola Manzella et al.

AGING CELL (2018)

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Article Cell Biology

Mitochondrial peptides modulate mitochondrial function during cellular senescence

Su-Jeong Kim et al.

AGING-US (2018)

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Article Clinical Neurology

Oligomeric amyloid β preferentially targets neuronal and not glial mitochondrial-encoded mRNAs

Diego Mastroeni et al.

ALZHEIMERS & DEMENTIA (2018)

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Review Cell Biology

Hallmarks of Brain Aging: Adaptive and Pathological Modification by Metabolic States

Mark P. Mattson et al.

CELL METABOLISM (2018)

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Article Cell Biology

The Mitochondrial-Encoded Peptide MOTS-c Translocates to the Nucleus to Regulate Nuclear Gene Expression in Response to Metabolic Stress

Kyung Hwa Kim et al.

CELL METABOLISM (2018)

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Article Cell Biology

PTEN-L is a novel protein phosphatase for ubiquitin dephosphorylation to inhibit PINK1-Parkin-mediated mitophagy

Liming Wang et al.

CELL RESEARCH (2018)

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Review Cell Biology

A Futile Battle? Protein Quality Control and the Stress of Aging

Ryo Higuchi-Sanabria et al.

DEVELOPMENTAL CELL (2018)

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Review Biochemistry & Molecular Biology

Emerging therapies for mitochondrial diseases

Michio Hirano et al.

MITOCHONDRIAL DISEASES (2018)

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Article Peripheral Vascular Disease

Chronic Supplementation With a Mitochondrial Antioxidant (MitoQ) Improves Vascular Function in Healthy Older Adults

Matthew J. Rossman et al.

HYPERTENSION (2018)

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Article Cardiac & Cardiovascular Systems

Mitochondrial calcium uniporter inhibition provides cardioprotection in pressure overload-induced heart failure through autophagy enhancement

Ziqing Yu et al.

INTERNATIONAL JOURNAL OF CARDIOLOGY (2018)

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Article Medicine, Research & Experimental

Systemic isradipine treatment diminishes calcium-dependent mitochondrial oxidant stress

Jaime N. Guzman et al.

JOURNAL OF CLINICAL INVESTIGATION (2018)

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Article Biochemistry & Molecular Biology

Mitochondrial Retrograde Signaling in Mammals Is Mediated by the Transcriptional Cofactor GPS2 via Direct Mitochondria-to-Nucleus Translocation

Maria Dafne Cardamone et al.

MOLECULAR CELL (2018)

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Article Multidisciplinary Sciences

Mechanism of parkin activation by PINK1

Christina Gladkova et al.

NATURE (2018)

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Article Biochemistry & Molecular Biology

Senolytics improve physical function and increase lifespan in old age

Ming Xu et al.

NATURE MEDICINE (2018)

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Review Cell Biology

Building and decoding ubiquitin chains for mitophagy

J. Wade Harper et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2018)

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Article Orthopedics

Parkin clearance of dysfunctional mitochondria regulates ROS levels and increases survival of human chondrocytes

M. Y. Ansari et al.

OSTEOARTHRITIS AND CARTILAGE (2018)

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Review Multidisciplinary Sciences

Spermidine in health and disease

Frank Madeo et al.

SCIENCE (2018)

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Article Cell Biology

Targeting mitochondrial responses to intra-articular fracture to prevent posttraumatic osteoarthritis

Mitchell C. Coleman et al.

SCIENCE TRANSLATIONAL MEDICINE (2018)

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Review Cell Biology

Hallmarks of Cellular Senescence

Alejandra Hernandez-Segura et al.

TRENDS IN CELL BIOLOGY (2018)

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Article Cell Biology

GSK3β Regulates Brain Energy Metabolism

Stephen A. Martin et al.

CELL REPORTS (2018)

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Article Cell Biology

The NAD plus Precursor Nicotinamide Riboside Rescues Mitochondrial Defects and Neuronal Loss in iPSC and Fly Models of Parkinson's Disease

David C. Schoendorf et al.

CELL REPORTS (2018)

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Review Cell Biology

The Role of Advanced Glycation End Products in Aging and Metabolic Diseases: Bridging Association and Causality

Jyotiska Chaudhuri et al.

CELL METABOLISM (2018)

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Editorial Material Cell Biology

A Mitochondrial-Derived Peptide Exercises the Nuclear Option

Kailash C. Mangalhara et al.

CELL METABOLISM (2018)

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Article Multidisciplinary Sciences

Parkin and PINK1 mitigate STING-induced inflammation

Danielle A. Sliter et al.

NATURE (2018)

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Review Multidisciplinary Sciences

Facing up to the global challenges of ageing

Linda Partridge et al.

NATURE (2018)

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Review Cell Biology

Mechanisms of mitophagy in cellular homeostasis, physiology and pathology

Konstantinos Palikaras et al.

NATURE CELL BIOLOGY (2018)

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Article Cell Biology

Melatonin Ameliorates the Progression of Atherosclerosis via Mitophagy Activation and NLRP3 Inflammasome Inhibition

Sai Ma et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2018)

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Review Cell Biology

No Parkin Zone: Mitophagy without Parkin

Elodie Villa et al.

TRENDS IN CELL BIOLOGY (2018)

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Article Multidisciplinary Sciences

Resveratrol Ameliorates Mitophagy Disturbance and Improves Cardiac Pathophysiology of Dystrophin-deficient mdx Mice

Atsushi Kuno et al.

SCIENTIFIC REPORTS (2018)

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Article Biochemistry & Molecular Biology

A novel lysosome-to-mitochondria signaling pathway disrupted by amyloid-beta oligomers

Andres Norambuena et al.

EMBO JOURNAL (2018)

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Article Biochemistry & Molecular Biology

Oleuropein Induces AMPK-Dependent Autophagy in NAFLD Mice, Regardless of the Gender

Cristiana Porcu et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

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Article Cell Biology

Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice

Richard Gordon et al.

SCIENCE TRANSLATIONAL MEDICINE (2018)

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Article Biology

Protective effects of metformin against osteoarthritis through upregulation of SIRT3-mediated PINK1/Parkin-dependent mitophagy- in primary chondrocytes

Chenzhong Wang et al.

BIOSCIENCE TRENDS (2018)

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Article Rheumatology

Mitochondrial DNA haplogroups influence the risk of incident knee osteoarthritis in OAI and CHECK cohorts. A meta-analysis and functional study

Mercedes Fernandez-Moreno et al.

ANNALS OF THE RHEUMATIC DISEASES (2017)

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Review Genetics & Heredity

Cell Biology of the Mitochondrion

Alexander M. van der Bliek et al.

GENETICS (2017)

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Article Cell Biology

Mitochondria and mitochondria-induced signalling molecules as longevity determinants

Giuseppina Rose et al.

MECHANISMS OF AGEING AND DEVELOPMENT (2017)

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Article Multidisciplinary Sciences

Enhancing mitochondrial proteostasis reduces amyloid-β proteotoxicity

Vincenzo Sorrentino et al.

NATURE (2017)

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Article Biochemistry & Molecular Biology

Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment

Ok Hee Jeon et al.

NATURE MEDICINE (2017)

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Review Biochemistry & Molecular Biology

Mitophagy in neurodegeneration and aging

Elayne M. Fivenson et al.

NEUROCHEMISTRY INTERNATIONAL (2017)

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Article Neurosciences

Releasing Syntaphilin Removes Stressed Mitochondria from Axons Independent of Mitophagy under Pathophysiological Conditions

Mei-Yao Lin et al.

NEURON (2017)

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Article Multidisciplinary Sciences

Increased mitochondrial fusion allows the survival of older animals in diverse C. elegans longevity pathways

Snehal N. Chaudhari et al.

NATURE COMMUNICATIONS (2017)

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Article Multidisciplinary Sciences

Promoting Drp1-mediated mitochondrial fission in midlife prolongs healthy lifespan of Drosophila melanogaster

Anil Rana et al.

NATURE COMMUNICATIONS (2017)

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Review Genetics & Heredity

Cell Biology of the Mitochondrion

Alexander M. van der Bliek et al.

GENETICS (2017)

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Review Geriatrics & Gerontology

Mitochondria and ageing: role in heart, skeletal muscle and adipose tissue

Kerstin Boengler et al.

JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE (2017)

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Review Biochemistry & Molecular Biology

Nuclear localization of metabolic enzymes in immunity and metastasis

Yuchen He et al.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2017)

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Article Cell Biology

Dietary Restriction and AMPK Increase Lifespan via Mitochondrial Network and Peroxisome Remodeling

Heather J. Weir et al.

CELL METABOLISM (2017)

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Article Biochemistry & Molecular Biology

Increased localization of APP-C99 in mitochondria-associated ER membranes causes mitochondrial dysfunction in Alzheimer disease

Marta Pera et al.

EMBO JOURNAL (2017)

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Review Cell Biology

Aging and osteoarthritis: Central role of the extracellular matrix

Maryam Rahmati et al.

AGEING RESEARCH REVIEWS (2017)

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Review Biochemistry & Molecular Biology

Modulating NAD+ metabolism, from bench tobedside

Elena Katsyuba et al.

EMBO JOURNAL (2017)

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Article Clinical Neurology

α-Synuclein binds to the ER-mitochondria tethering protein VAPB to disrupt Ca2+ homeostasis and mitochondrial ATP production

Sebastien Paillusson et al.

ACTA NEUROPATHOLOGICA (2017)

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Review Biochemistry & Molecular Biology

Senescence in Health and Disease

Shenghui He et al.

CELL (2017)

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Review Cell Biology

Mammalian Mitochondria and Aging: An Update

Timo E. S. Kauppila et al.

CELL METABOLISM (2017)

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Review Chemistry, Multidisciplinary

Chemical Synthesis of Peptides Containing Site-Specific Advanced Glycation Endproducts

Harveen Kaur et al.

ACCOUNTS OF CHEMICAL RESEARCH (2016)

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Review Clinical Neurology

Mitochondria-associated membranes as hubs for neurodegeneration

Michiel Krols et al.

ACTA NEUROPATHOLOGICA (2016)

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Article Cardiac & Cardiovascular Systems

Drp1-Dependent Mitochondrial Autophagy Plays a Protective Role Against Pressure Overload-Induced Mitochondrial Dysfunction and Heart Failure

Akihiro Shirakabe et al.

CIRCULATION (2016)

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Review Biochemistry & Molecular Biology

The Mitochondrial Basis of Aging

Nuo Sun et al.

MOLECULAR CELL (2016)

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Review Multidisciplinary Sciences

Defects in trafficking bridge Parkinson's disease pathology and genetics

Asa Abeliovich et al.

NATURE (2016)

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Article Biochemistry & Molecular Biology

Urolithin A induces mitophagy and prolongs lifespan in C-elegans and increases muscle function in rodents

Dongryeol Ryu et al.

NATURE MEDICINE (2016)

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Review Cell Biology

Mitonuclear communication in homeostasis and stress

Pedro M. Quiros et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2016)

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Review Rheumatology

Ageing and the pathogenesis of osteoarthritis

Richard F. Loeser et al.

NATURE REVIEWS RHEUMATOLOGY (2016)

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Editorial Material Cell Biology

Mitochondrial Health in Aging and Age-Related Metabolic Disease

David Sebastian et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2016)

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Article Multidisciplinary Sciences

Effect of Exendin-4 on Autophagy Clearance in Beta Cell of Rats with Tacrolimus-induced Diabetes Mellitus

Sun Woo Lim et al.

SCIENTIFIC REPORTS (2016)

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Article Cell Biology

Imeglimin prevents human endothelial cell death by inhibiting mitochondrial permeability transition without inhibiting mitochondrial respiration

D. Detaille et al.

CELL DEATH DISCOVERY (2016)

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Editorial Material Cell Biology

The mitochondrial-derived peptide MOTS-c: a player in exceptional longevity?

Noriyuki Fuku et al.

AGING CELL (2015)

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Article Cell Biology

The Mitochondrial-Derived Peptide MOTS-c Promotes Metabolic Homeostasis and Reduces Obesity and Insulin Resistance

Changhan Lee et al.

CELL METABOLISM (2015)

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Article Multidisciplinary Sciences

The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy

Michael Lazarou et al.

NATURE (2015)

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Article Oncology

Mitochondrial morphology is altered in atrophied skeletal muscle of aged mice

Jean-Philippe Leduc-Gaudet et al.

ONCOTARGET (2015)

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Article Multidisciplinary Sciences

Punicalagin, an active component in pomegranate, ameliorates cardiac mitochondrial impairment in obese rats via AMPK activation

Ke Cao et al.

SCIENTIFIC REPORTS (2015)

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Article Medicine, General & Internal

Alzheimer's disease

Colin L. Masters et al.

NATURE REVIEWS DISEASE PRIMERS (2015)

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Advanced glycation end products-induced chondrocyte apoptosis through mitochondrial dysfunction in cultured rabbit chondrocyte

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