Myocardin-related transcription factor A, regulated by serum response factor, contributes to diabetic cardiomyopathy in mice

Article Medicine, Research & Experimental

Slug enables redox-sensitive trans-activation of LRP1 by COUP-TFII: Implication in antifibrotic intervention in the kidneys

Xiaoyan Wu et al.

Summary: This study reveals that Slug is involved in regulating fibroblast-myofibroblast transition and renal fibrosis by modulating the expression of key transcription factors and ROS levels.

LIFE SCIENCES (2023)

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Review Cardiac & Cardiovascular Systems

Global burden of heart failure: a comprehensive and updated review of epidemiology

Gianluigi Savarese et al.

Summary: Heart Failure (HF) is a multi-faceted and life-threatening syndrome with significant morbidity and mortality worldwide, affecting over 64 million people. While the incidence of HF has stabilized in industrialized countries, the prevalence is increasing due to population ageing and improved treatment. Developing countries lack substantial data on HF epidemiology, which shows different features compared to the Western world. This review provides updated estimates on global burden of HF including prevalence, incidence, outcomes, and costs.

CARDIOVASCULAR RESEARCH (2022)

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Article Cardiac & Cardiovascular Systems

Myocardin-related transcription factor A regulates integrin beta 2 transcription to promote macrophage infiltration and cardiac hypertrophy in mice

Li Liu et al.

Summary: Macrophage-specific deletion of MRTF-A can alleviate cardiac hypertrophy, reduce heart function loss, and decrease cardiac fibrosis. The study suggests that MRTF-A may regulate macrophage activity and contribute to the pathogenesis of cardiac hypertrophy by activating ITGB2 transcription.

CARDIOVASCULAR RESEARCH (2022)

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Article Endocrinology & Metabolism

Heart Failure: An Underappreciated Complication of Diabetes. A Consensus Report of the American Diabetes Association

Rodica Pop-Busui et al.

Summary: Heart failure is a common complication of diabetes, even in the absence of other cardiovascular diseases. With the increasing prevalence of diabetes globally, particularly type 2 diabetes, the burden of heart failure on the healthcare system is expected to rise. This consensus report aims to provide clear guidance to practitioners on screening and diagnosing heart failure in individuals with diabetes.

DIABETES CARE (2022)

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Article Cell Biology

Trans-activation of eotaxin-1 by Brg1 contributes to liver regeneration

Zhiwen Fan et al.

Summary: Infiltration of eosinophils is associated with and contributes to liver regeneration. Eotaxin-1 expression is elevated in proliferating murine livers and can be stimulated by hepatocyte growth factor (HGF). Brg1 is a chromatin remodeling protein that directly binds to the eotaxin promoter to activate its transcription, and interacts with NF-kappa B/RelA to activate eotaxin transcription. Depletion of eotaxin or Brg1 deficiency delays liver regeneration.

CELL DEATH & DISEASE (2022)

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Article Cell Biology

Mitochondrial damage and activation of the cytosolic DNA sensor cGAS-STING pathway lead to cardiac pyroptosis and hypertrophy in diabetic cardiomyopathy mice

Meiling Yan et al.

Summary: This study found that the cGAS-STING signaling pathway is activated in diabetic hearts, leading to the activation of the NLRP3 inflammasome and release of proinflammatory cytokines. Knockdown of STING can alleviate cardiac pyroptosis and inflammation, and prevent diabetes-induced cardiac hypertrophy.

CELL DEATH DISCOVERY (2022)

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Article Medicine, Research & Experimental

Exercise training after myocardial infarction increases survival but does not prevent adverse left ventricle remodeling and dysfunction in high-fat diet fed mice

Carmem Peres Valgas Da Silva et al.

Summary: This study demonstrates that aerobic exercise can significantly improve survival after myocardial infarction (MI), independent of its effects on cardiac function. However, exercise does not have an impact on obesity and glucose intolerance induced by a high-fat diet (HFD). This highlights the importance of considering environmental interventions, including diet, in the cardiac rehabilitation of obese patients.

LIFE SCIENCES (2022)

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Article Cardiac & Cardiovascular Systems

SIRT6 Mitigates Heart Failure With Preserved Ejection Fraction in Diabetes

Xiaoqian Wu et al.

Summary: The study reveals that reduced endothelial SIRT6 expression is associated with the development of diabetes-related HFpEF, and improving cardiac function by inhibiting endothelial fatty acid uptake. Activation of SIRT6 with medication reduces cardiac lipid accumulation and improves diastolic function.

CIRCULATION RESEARCH (2022)

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Article Medicine, Research & Experimental

Thyroid hormone mediates cardioprotection against postinfarction remodeling and dysfunction through the IGF-1/PI3K/AKT signaling pathway

Bin Zeng et al.

Summary: The study found that T3 pretreatment significantly reduces myocardial infarct area, inhibits cardiomyocyte apoptosis and fibrosis, and improves left ventricular function post-MI. Furthermore, T3 can also promote angiogenesis, reduce inflammatory cytokines, and protect the heart from damage after MI.

LIFE SCIENCES (2021)

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Article Cell Biology

The Chromatin Remodeling Protein BRG1 Regulates SREBP Maturation by Activating SCAP Transcription in Hepatocytes

Ming Kong et al.

Summary: BRG1 deficiency in mice results in reduced processing and nuclear accumulation of SREBP in the liver, affecting lipid metabolism. BRG1 plays a crucial role in regulating SREBP by activating SCAP transcription, ultimately influencing SREBP target gene expression.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Article Biochemistry & Molecular Biology

Redox-sensitive activation of CCL7 by BRG1 in hepatocytes during liver injury

Ming Kong et al.

Summary: Liver injuries induced by various stimuli lead to an upregulation of CCL7 expression, which plays an important role in macrophage migration during liver injury. This process is regulated by BRG1, which interacts with AP-1 and is phosphorylated by CK2, and this pathway is sensitive to redox changes. This study provides new insights into the mechanisms of liver inflammation and repair.

REDOX BIOLOGY (2021)

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Article Cell Biology

An E2F5-TFDP1-BRG1 Complex Mediates Transcriptional Activation of MYCN in Hepatocytes

Zhiwen Fan et al.

Summary: The research identified a novel epigenetic pathway in which an E2F5-TFDP1-BRG1 complex regulates MYCN transcription to promote liver regeneration.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Article Medicine, Research & Experimental

Nicotinamide mononucleotide attenuates isoproterenol-induced cardiac fibrosis by regulating oxidative stress and Smad3 acetylation

Keke Wu et al.

Summary: Nicotinamide mononucleotide (NMN) can attenuate cardiac fibrosis in vivo and fibroblast activation in vitro by suppressing oxidative stress and Smad3 acetylation in a NAD(+)/SIRT1-dependent manner.

LIFE SCIENCES (2021)

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Article Cell Biology

Choline Kinase Alpha Is a Novel Transcriptional Target of the Brg1 in Hepatocyte: Implication in Liver Regeneration

Ming Kong et al.

Summary: Liver regeneration is a crucial compensatory process in response to liver injury, and studies have found that Brg1-dependent trans-activation of Chka expression may contribute to promoting liver regeneration.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Review Cardiac & Cardiovascular Systems

Cardiac fibrosis

Nikolaos G. Frangogiannis

Summary: Myocardial fibrosis, characterized by the expansion of cardiac interstitium through deposition of extracellular matrix proteins, is a common pathophysiologic feature in various myocardial conditions. Activated fibroblasts and myofibroblasts play a central role in cardiac fibrosis, producing matrix proteins and triggering fibrogenic signalling cascades in response to stress. Immune cells, vascular cells, and cardiomyocytes can also contribute to fibrosis, while fibrotic changes may disrupt cardiac function and play a role in arrhythmogenesis.

CARDIOVASCULAR RESEARCH (2021)

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Article Cardiac & Cardiovascular Systems

Heart Disease and Stroke Statistics-2020 Update: A Report From the American Heart Association

Salim S. Virani et al.

CIRCULATION (2020)

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Article Cell Biology

An Interplay Between MRTF-A and the Histone Acetyltransferase TIP60 Mediates Hypoxia-Reoxygenation Induced iNOS Transcription in Macrophages

Yuyu Yang et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

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Article Cell Biology

An MRTF-A-Sp1-PDE5 Axis Mediates Angiotensin-II-Induced Cardiomyocyte Hypertrophy

Teng Wu et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

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Article Biochemistry & Molecular Biology

A hypothesis for insulin resistance in primary human adipocytes involving MRTF-A and suppression of PPARγ

Bjorn Hansson et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)

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Article Multidisciplinary Sciences

Oligogenic inheritance of a human heart disease involving a genetic modifier

Casey A. Gifford et al.

SCIENCE (2019)

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Article Medicine, Research & Experimental

Nuclear receptor corepressor 1 represses cardiac hypertrophy

Chao Li et al.

EMBO MOLECULAR MEDICINE (2019)

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Article Genetics & Heredity

Ablation of serum response factor in hepatic stellate cells attenuates liver fibrosis

Ming Kong et al.

JOURNAL OF MOLECULAR MEDICINE-JMM (2019)

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Article Cardiac & Cardiovascular Systems

Diabetic cardiomyopathy

Matthew Meng Yang Lee et al.

HEART (2019)

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Article Cardiac & Cardiovascular Systems

Mechanosensitive Gene Regulation by Myocardin-Related Transcription Factors Is Required for Cardiomyocyte Integrity in Load-Induced Ventricular Hypertrophy

Michael A. Trembley et al.

CIRCULATION (2018)

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Article Cardiac & Cardiovascular Systems

Megakaryocytic Leukemia 1 Bridges Epigenetic Activation of NADPH Oxidase in Macrophages to Cardiac Ischemia-Reperfusion Injury

Liming Yu et al.

CIRCULATION (2018)

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Review Cardiac & Cardiovascular Systems

Diabetic Cardiomyopathy: An Update of Mechanisms Contributing to This Clinical Entity

Guanghong Jia et al.

CIRCULATION RESEARCH (2018)

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Article Cell Biology

MRTF-A mediated FN and ICAM-1 expression in AGEs-induced rat glomerular mesangial cells via activating STAT5

Qiuhong Chen et al.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2018)

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Article Endocrinology & Metabolism

Metallothionein Is Downstream of Nrf2 and Partially Mediates Sulforaphane Prevention of Diabetic Cardiomyopathy

Junlian Gu et al.

DIABETES (2017)

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Article Multidisciplinary Sciences

The histone H3K9 methyltransferase SUV39H links SIRT1 repression to myocardial infarction

Guang Yang et al.

NATURE COMMUNICATIONS (2017)

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Article Biochemistry & Molecular Biology

Elevated Glucose Levels Promote Contractile and Cytoskeletal Gene Expression in Vascular Smooth Muscle via Rho/Protein Kinase C and Actin Polymerization

Tran Thi Hien et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2016)

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Article Pharmacology & Pharmacy

Anti-apoptotic effects of myocardin-related transcription factor-A on rat cardiomyocytes following hypoxia-induced injury

Ze Zhong et al.

CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY (2016)

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Article Cardiac & Cardiovascular Systems

The fibrosis-cell death axis in heart failure

A. Piek et al.

HEART FAILURE REVIEWS (2016)

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Review Medicine, Research & Experimental

The pathogenesis of insulin resistance: integrating signaling pathways and substrate flux

Varman T. Samuel et al.

JOURNAL OF CLINICAL INVESTIGATION (2016)

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Review Cardiac & Cardiovascular Systems

Epidemiology and aetiology of heart failure

Boback Ziaeian et al.

NATURE REVIEWS CARDIOLOGY (2016)

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Article Multidisciplinary Sciences

Genetic lineage tracing defines myofibroblast origin and function in the injured heart

Onur Kanisicak et al.

NATURE COMMUNICATIONS (2016)

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Article Biochemistry & Molecular Biology

Myocardin-Related Transcription Factor A Regulates Conversion of Progenitors to Beige Adipocytes

Meghan E. McDonald et al.

CELL (2015)

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Article Pharmacology & Pharmacy

Baicalin inhibiting cerebral ischemia/hypoxia-induced neuronal apoptosis via MRTF-A-mediated transactivity

Wen-xia Zheng et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2015)

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Article Endocrinology & Metabolism

Type 2 diabetes and incidence of cardiovascular diseases: a cohort study in 1.9 million people

Anoop Dinesh Shah et al.

LANCET DIABETES & ENDOCRINOLOGY (2015)

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Article Urology & Nephrology

Myocardin-Related Transcription Factor A Epigenetically Regulates Renal Fibrosis in Diabetic Nephropathy

Huihui Xu et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2015)

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Article Multidisciplinary Sciences

Regulation of MKL1 via actin cytoskeleton dynamics drives adipocyte differentiation

Hiroyuki Nobusue et al.

NATURE COMMUNICATIONS (2014)

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Article Cardiac & Cardiovascular Systems

TLR4 regulates cardiac lipid accumulation and diabetic heart disease in the nonobese diabetic mouse model of type 1 diabetes

Baojun Dong et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2012)

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Article Biochemistry & Molecular Biology

Reciprocal expression of MRTF-A and myocardin is crucial for pathological vascular remodelling in mice

Takeya Minami et al.

EMBO JOURNAL (2012)

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Article Medicine, Research & Experimental

Metabolic stress-induced activation of FoxO1 triggers diabetic cardiomyopathy in mice

Pavan K. Battiprolu et al.

JOURNAL OF CLINICAL INVESTIGATION (2012)

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Article Cardiac & Cardiovascular Systems

Myocardin-Related Transcription Factor A Mediates OxLDL-Induced Endothelial Injury

Fei Fang et al.

CIRCULATION RESEARCH (2011)

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Article Medicine, Research & Experimental

Increased SRF transcriptional activity in human and mouse skeletal muscle is a signature of insulin resistance

Wanzhu Jin et al.

JOURNAL OF CLINICAL INVESTIGATION (2011)

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Article Biochemistry & Molecular Biology

Myocardin-Related Transcription Factor A Is a Common Mediator of Mechanical Stress- and Neurohumoral Stimulation-Induced Cardiac Hypertrophic Signaling Leading to Activation of Brain Natriuretic Peptide Gene Expression

Koichiro Kuwahara et al.

MOLECULAR AND CELLULAR BIOLOGY (2010)

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Article Cardiac & Cardiovascular Systems

Substrate-Specific Derangements in Mitochondrial Metabolism and Redox Balance in the Atrium of the Type 2 Diabetic Human Heart

Ethan J. Anderson et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2009)

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Article Cardiac & Cardiovascular Systems

Nix-mediated apoptosis links myocardial fibrosis, cardiac remodeling, and hypertrophy decompensation

Abhinav Diwan et al.

CIRCULATION (2008)

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Article Medicine, Research & Experimental

Cardiomyocyte expression of PPARγ leads to cardiac dysfunction in mice

Ni-Huiping Son et al.

JOURNAL OF CLINICAL INVESTIGATION (2007)

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Article Cardiac & Cardiovascular Systems

Cardiac steatosis in diabetes mellitus -: A 1H-magnetic resonance spectroscopy study

Jonathan M. McGavock et al.

CIRCULATION (2007)

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Article Biochemistry & Molecular Biology

Requirement of a myocardin-related transcription factor for development of mammary myoepithelial cells

Shijie Li et al.

MOLECULAR AND CELLULAR BIOLOGY (2006)

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Article Cardiac & Cardiovascular Systems

Myocardin induces cardiomyocyte hypertrophy

WB Xing et al.

CIRCULATION RESEARCH (2006)

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Article Physiology

Abrogation of bleomycin-induced epithelial apoptosis and lung fibrosis by captopril or by a caspase inhibitor

RQ Wang et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2000)

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Myocardin-related transcription factor A, regulated by serum response factor, contributes to diabetic cardiomyopathy in mice

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