Mapping antigens of membranous nephropathy: almost there

Article Urology & Nephrology

Discovery of seven novel putative antigens in membranous and membranous lupus nephritis identified by mass spectrometry

Tiffany N. Caza et al.

Summary: Multiple new antigenic targets have been identified in PLA2R-/THSD7A-/EXT-/NELL1-quadruple negative MN biopsies through mass spectrometry of immune complexes. These discoveries expand our understanding of the disease and may contribute to the development of new diagnostic approaches.

KIDNEY INTERNATIONAL (2023)

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Article Urology & Nephrology

Hematopoietic Stem Cell Transplant-M embranous Nephropathy Is Associated with Protocadherin FAT1

Sanjeev Sethi et al.

Summary: In this study, a novel antigen associated with membranous nephropathy (MN) in patients receiving hematopoietic stem cell transplant (HSCT) was identified using laser microdissection and tandem mass spectrometry (MS/MS). The antigen, called FAT1, was detected in the glomeruli of patients with PLA2R-negative MN. Further studies confirmed the presence of FAT1-associated MN in a majority of HSCT-related MN cases. This study provides valuable insights into the pathogenesis of MN in HSCT patients and may contribute to the development of targeted therapies.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2022)

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Article Urology & Nephrology

Neural cell adhesion molecule 1 is a novel autoantigen in membranous lupus nephritis

Tiffany N. Caza et al.

Summary: Research has identified neural cell adhesion molecule 1 (NCAM1) as a target antigen in some cases of membranous lupus nephritis and rare cases of primary membranous nephropathy, colocalizing with IgG in glomerular immune deposits. Circulating antibodies to NCAM1 have been detected in serum of patients with NCAM1-associated membranous nephropathy, suggesting diagnostic significance. Future studies are needed to determine whether anti-NCAM1 antibody levels correlate with disease activity or response to therapy.

KIDNEY INTERNATIONAL (2021)

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Review Urology & Nephrology

New 'Antigens' in Membranous Nephropathy

Sanjeev Sethi

Summary: Membranous nephropathy is a disease caused by immune complex deposition along the glomerular basement membrane, with PLA2R and THSD7A being the main antigens. New mass spectrometry techniques have led to the discovery of four novel types of MN, each with distinct clinical and pathologic features. Additional studies are needed to understand the pathophysiology, treatment response, and outcomes of these new MN subtypes.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2021)

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Article Urology & Nephrology

Protocadherin 7?Associated Membranous Nephropathy

Sanjeev Sethi et al.

Summary: Membranous nephropathy (MN) can be caused by antibodies targeting different antigens in the glomerular basement membrane (GBM), such as PLA2R, THSD7A, NELL1, SEMA3B, and now, the novel protein PCHD7. PCHD7 appears to define a distinct type of MN with specific characteristics in terms of staining pattern and antibody reactivity.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2021)

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Article Urology & Nephrology