☆ 4.6 Article

Immunity to Seasonal Coronavirus Spike Proteins Does Not Protect from SARS-CoV-2 Challenge in a Mouse Model but Has No Detrimental Effect on Protection Mediated by COVID-19 mRNA Vaccination

JOURNAL OF VIROLOGY (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Multidisciplinary Sciences

Activity of convalescent and vaccine serum against SARS-CoV-2 Omicron

Juan Manuel Carreno et al.

Summary: The Omicron variant of SARS-CoV-2, first identified in South Africa and Botswana in November 2021, has rapidly spread globally with high transmissibility. It has an unprecedented number of mutations in its spike gene, leading to immune escape and reduced vaccine efficacy. The neutralizing and binding activity against Omicron varies among individuals with different vaccination and infection histories.

NATURE (2022)

添加到收藏夹

Article Multidisciplinary Sciences

Cross-reactive memory T cells associate with protection against SARS-CoV-2 infection in COVID-19 contacts

Rhia Kundu et al.

Nature Communications (2022)

添加到收藏夹

Article Multidisciplinary Sciences

Close relatives of MERS-CoV in bats use ACE2 as their functional receptors

Qing Xiong et al.

Summary: Middle East respiratory syndrome coronavirus (MERS-CoV) and its close relative NeoCoV can efficiently bind to specific bat ACE2 orthologues and, less favorably, human ACE2 as entry receptors through their RBDs. The RBD-ACE2 binding interface involves protein-glycan interactions, distinct from other known ACE2-using coronaviruses. The findings suggest a promiscuity of receptor use and a potential zoonotic threat.

NATURE (2022)

添加到收藏夹

Article Medicine, General & Internal

Multivalent S2-based vaccines provide broad protection against SARS-CoV-2 variants of concern and pangolin coronaviruses

Peter J. Halfmann et al.

Summary: Researchers have developed a vaccine based on the conserved S2 subunit of the S protein and optimized the adjuvant and immunization regimen. The vaccine showed efficacy against SARS-CoV-2 variants and other coronaviruses.

EBIOMEDICINE (2022)

添加到收藏夹

Article Cell Biology

SARS-CoV-2 S2-targeted vaccination elicits broadly neutralizing antibodies

Kevin W. Ng et al.

Summary: This study found that prior immunity to HCoV-OC43 S virus can enhance the immune response to SARS-CoV-2 infection and provide a certain level of protection. In addition, vaccination with SARS-CoV-2 S2 elicited antibodies that can neutralize various coronaviruses and provide protection against SARS-CoV-2 infection. Furthermore, repeated S2 vaccination induced broader neutralizing antibody response, preventing repertoire focusing caused by repeated homologous vaccination.

SCIENCE TRANSLATIONAL MEDICINE (2022)

添加到收藏夹

Article Microbiology

Trivalent NDV-HXP-S Vaccine Protects against Phylogenetically Distant SARS-CoV-2 Variants of Concern in Mice

Irene Gonzalez-Dominguez et al.

Summary: This paper describes an extended work on the Newcastle disease virus (NDV)-based vaccine focusing on multivalent formulations of NDV vectors expressing different prefusion-stabilized versions of the spike proteins of different SARS-CoV-2 variants of concern (VOC). It demonstrates that this low-cost NDV platform can be easily adapted to construct vaccines against SARS-CoV-2 variants. Importantly, the trivalent preparation (composed of the ancestral Wuhan, Beta, and Delta vaccines) substantially increases the levels of protection and of cross-neutralizing antibodies against mismatched, phylogenetically distant variants (including the currently circulating Omicron variant). These findings will help guide efforts for pandemic preparedness against new variants in the future.

MICROBIOLOGY SPECTRUM (2022)

添加到收藏夹

Article Infectious Diseases

Isolation of Human Coronaviruses OC43, HKU1, NL63, and 229E in Yamagata, Japan, Using Primary Human Airway Epithelium Cells Cultured by Employing an Air-Liquid Interface Culture

Kenichi Komabayashi et al.

Summary: The study aimed to isolate seasonal coronaviruses from human airway epithelium using modified culture methods. The results showed that ALI culture was effective in isolating HCoVs, particularly in obtaining HCoV-OC43 and HCoV-NL63. Furthermore, the LLC-MK2 cell line in combination with ALI cultures was successful in large-scale culturing of HCoV-NL63.

JAPANESE JOURNAL OF INFECTIOUS DISEASES (2021)

添加到收藏夹

Article Multidisciplinary Sciences

A Newcastle disease virus expressing a stabilized spike protein of SARS-CoV-2 induces protective immune responses

Weina Sun et al.

Summary: The rapid development of COVID-19 vaccines has been crucial in mitigating the spread of SARS-CoV-2, but equitable allocation of vaccines is necessary to limit global impact and the emergence of variants. A Newcastle disease virus-based COVID-19 vaccine candidate has been developed, inducing protective immunity in various animal models.

NATURE COMMUNICATIONS (2021)

添加到收藏夹

Article Cell Biology

Stabilized coronavirus spike stem elicits a broadly protective antibody

Ching-Lin Hsieh et al.

Summary: This study developed stabilized stem (SS) antigens by removing the S1 subunit from the Middle East respiratory syndrome (MERS)-CoV spike (S) glycoprotein using structure-guided protein engineering. Vaccination with MERS SS elicited cross-reactive b-CoV antibody responses and protected mice against lethal MERS-CoV challenge. The discovery of a panel of cross-reactive monoclonal antibodies, among which IgG22 showed high affinity binding to both MERS-CoV and severe acute respiratory syndrome (SARS)-CoV-2 S proteins, indicates the potential for cross-reactive CoV antibodies.

CELL REPORTS (2021)

添加到收藏夹

Article Immunology

Coronavirus Occurrence in the Household Influenza Vaccine Evaluation (HIVE) Cohort of Michigan Households: Reinfection Frequency and Serologic Responses to Seasonal and Severe Acute Respiratory Syndrome Coronaviruses

Joshua G. Petrie et al.

Summary: Reinfection with seasonal HCoVs is frequent, and binding anti-spike protein antibodies do not correlate with protection from seasonal HCoV infection, with little cross-response to SARS-CoV-2 proteins.

JOURNAL OF INFECTIOUS DISEASES (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Cross-reactive serum and memory B-cell responses to spike protein in SARS-CoV-2 and endemic coronavirus infection

Ge Song et al.

Summary: This study examines the impact of pre-existing immunity to seasonal endemic coronaviruses on antibody responses to SARS-CoV-2, finding weak evidence of pre-existing cross-reactive serum antibodies in pre-pandemic donors, but evidence of pre-existing cross-reactive memory B cells activated during SARS-CoV-2 infection. Monoclonal antibodies show varying degrees of cross-reactivity with betacoronaviruses, and one neutralizing antibody specific to the S2 subunit of the S protein is identified, suggesting that pre-existing immunity to endemic coronaviruses should be considered in evaluating antibody responses to SARS-CoV-2.

NATURE COMMUNICATIONS (2021)

添加到收藏夹

Article Multidisciplinary Sciences

A conserved immunogenic and vulnerable site on the coronavirus spike protein delineated by cross-reactive monoclonal antibodies

Chunyan Wang et al.

Summary: Research has isolated two human monoclonal antibodies from immunized humanized mice that display cross-reactivity against various beta coronaviruses, targeting the stem helix in the spike S2 fusion subunit. These antibodies block MERS-CoV infection in cells and provide protection against lethal MERS-CoV challenge in mice, showcasing their potential for developing broad-spectrum antibodies. Despite exhibiting cross-reactivity, the antibodies only neutralize MERS-CoV due to subtle epitope differences in the spike S2 fusion subunit.

NATURE COMMUNICATIONS (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

SARS-CoV-2 mRNA vaccination induces functionally diverse antibodies to NTD, RBD, and S2

Fatima Amanat et al.

Summary: After receiving the SARS-CoV-2 spike mRNA vaccine, individuals showed robust polyclonal antibody responses, with a majority of vaccine-induced antibodies lacking neutralizing activity. However, vaccine-induced RBD binding antibodies may offer substantial protection against viral variants carrying single E484K RBD mutations.

CELL (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Broad betacoronavirus neutralization by a stem helix-specific human antibody

Dora Pinto et al.

Summary: The study identified five monoclonal antibodies from COVID-19 convalescent individuals that cross-react with multiple betacoronavirus spike glycoproteins, with one antibody (S2P6) showing broad neutralization of viruses from three different subgenera. This antibody reduced viral burden in hamsters challenged with SARS-CoV-2 by inhibiting membrane fusion, providing a framework for the design of pan-betacoronavirus vaccines for broad protection.

SCIENCE (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Immunological imprinting of the antibody response in COVID-19 patients

Teresa Aydillo et al.

Summary: The study found that previous infections with seasonal coronaviruses can affect the antibody response to SARS-CoV-2 in COVID-19 patients. While SARS-CoV-2 infection can boost pre-existing responses to other coronaviruses, this back-boosting hampers the induction of specific antibodies against SARS-CoV-2.

NATURE COMMUNICATIONS (2021)

添加到收藏夹

Article Medicine, General & Internal

Humoral immunity to SARS-CoV-2 and seasonal coronaviruses in children and adults in north-eastern France

Tom Woudenberg et al.

Summary: Children are found to have milder disease in the COVID-19 pandemic in comparison to adolescents and adults. A study in north-eastern France showed a seroprevalence of 7-8% for SARS-CoV-2-specific antibodies, with significant increases in antibody levels to seasonal HCoV in children under 10 years old.

EBIOMEDICINE (2021)

添加到收藏夹

Article Medicine, General & Internal

A Novel Coronavirus from Patients with Pneumonia in China, 2019

Na Zhu et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

添加到收藏夹

Article Immunology

Activity of human serum antibodies in an influenza virus hemagglutinin stalk-based ADCC reporter assay correlates with activity in a CD107a degranulation assay

Veronika Chromikova et al.

VACCINE (2020)

添加到收藏夹

Article Immunology

Coronavirus Occurrence and Transmission Over 8 Years in the HIVE Cohort of Households in Michigan

Arnold S. Monto et al.

JOURNAL OF INFECTIOUS DISEASES (2020)

添加到收藏夹

Article Immunology

A Single Immunization with Nucleoside-Modified mRNA Vaccines Elicits Strong Cellular and Humoral Immune Responses against SARS-CoV-2 in Mice

Dorottya Laczko et al.

IMMUNITY (2020)

添加到收藏夹

Article Physiology

Human coronaviruses 229E and OC43 replicate and induce distinct antiviral responses in differentiated primary human bronchial epithelial cells

Su-Ling Loo et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Selective and cross-reactive SARS-CoV-2 T cell epitopes in unexposed humans

Jose Mateus et al.

SCIENCE (2020)

添加到收藏夹

Review Multidisciplinary Sciences

A systematic review of antibody mediated immunity to coronaviruses: kinetics, correlates of protection, and association with severity

Angkana T. Huang et al.

NATURE COMMUNICATIONS (2020)

添加到收藏夹

Article Immunology

Comparison of transgenic and adenovirus hACE2 mouse models for SARS-CoV-2 infection

Raveen Rathnasinghe et al.

EMERGING MICROBES & INFECTIONS (2020)

添加到收藏夹

Article Immunology

SARS-CoV-2 mRNA Vaccines Foster Potent Antigen-Specific Germinal Center Responses Associated with Neutralizing Antibody Generation

Katlyn Lederer et al.

IMMUNITY (2020)

添加到收藏夹

Article Medicine, General & Internal

Newcastle disease virus (NDV) expressing the spike protein of SARS-CoV-2 as a live virus vaccine candidate

Weina Sun et al.

EBIOMEDICINE (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Preexisting and de novo humoral immunity to SARS-CoV-2 in humans

Kevin W. Ng et al.

SCIENCE (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Robust neutralizing antibodies to SARS-CoV-2 infection persist for months

Ania Wajnberg et al.

SCIENCE (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Human coronaviruses OC43 and HKU1 bind to 9-O-acetylated sialic acids via a conserved receptor-binding site in spike protein domain A

Ruben J. G. Hulswit et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

添加到收藏夹

Article Medicine, Research & Experimental

A Facile Method for the Removal of dsRNA Contaminant from In Vitro-Transcribed mRNA

Markus Baiersdoerfer et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2019)

添加到收藏夹

Article Immunology

Cross-reactive antibodies binding to H4 hemagglutinin protect against a lethal H4N6 influenza virus challenge in the mouse model

Fatima Amanat et al.

EMERGING MICROBES & INFECTIONS (2019)

添加到收藏夹

Review Immunology

The human antibody response to influenza A virus infection and vaccination

Florian Krammer

NATURE REVIEWS IMMUNOLOGY (2019)

添加到收藏夹

Article Infectious Diseases

Human coronaviruses and other respiratory infections in young adults on a university campus: Prevalence, symptoms, and shedding

Brian M. Davis et al.

INFLUENZA AND OTHER RESPIRATORY VIRUSES (2018)

添加到收藏夹

Article Multidisciplinary Sciences

An immuno-assay to quantify influenza virus hemagglutinin with correctly folded stalk domains in vaccine preparations

Madhusudan Rajendran et al.

PLOS ONE (2018)

添加到收藏夹

Article Microbiology

Antibodies to the Glycoprotein GP2 Subunit Cross-React between Old and New World Arenaviruses

Fatima Amanat et al.

MSPHERE (2018)

添加到收藏夹

Article Virology

Novel Cross-Reactive Monoclonal Antibodies against Ebolavirus Glycoproteins Show Protection in a Murine Challenge Model

James Duehr et al.

JOURNAL OF VIROLOGY (2017)

添加到收藏夹

Article Microbiology

Broadly protective murine monoclonal antibodies against influenza B virus target highly conserved neuraminidase epitopes

Teddy John Wohlbold et al.

NATURE MICROBIOLOGY (2017)

添加到收藏夹

Article Virology

Hemagglutinin Stalk- and Neuraminidase-Specific Monoclonal Antibodies Protect against Lethal H10N8 Influenza Virus Infection in Mice

Teddy John Wohlbold et al.

JOURNAL OF VIROLOGY (2016)

添加到收藏夹

Article Microbiology

Vaccination with Adjuvanted Recombinant Neuraminidase Induces Broad Heterologous, but Not Heterosubtypic, Cross-Protection against Influenza Virus Infection in Mice

Teddy John Wohlbold et al.

MBIO (2015)

添加到收藏夹

Article Multidisciplinary Sciences

Systematic Characterization and Comparative Analysis of the Rabbit Immunoglobulin Repertoire

Jason J. Lavinder et al.

PLOS ONE (2014)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Biodegradable Lipids Enabling Rapidly Eliminated Lipid Nanoparticles for Systemic Delivery of RNAi Therapeutics

Martin A. Maier et al.

MOLECULAR THERAPY (2013)

添加到收藏夹

Article Multidisciplinary Sciences

Crystal structure of NL63 respiratory coronavirus receptor-binding domain complexed with its human receptor

Kailang Wu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

添加到收藏夹

Article Multidisciplinary Sciences

Human coronavirus NL63 employs the severe acute respiratory syndrome coronavirus receptor for cellular entry

H Hofmann et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

添加到收藏夹

Article Virology

Complete genomic sequence of human coronavirus OC43:: Molecular clock analysis suggests a relatively recent zoonotic coronavirus transmission event

L Vijgen et al.

JOURNAL OF VIROLOGY (2005)

添加到收藏夹

Article Virology

Characterization and complete genome sequence of a novel coronavirus, coronavirus HKU1, from patients with pneumonia

PCY Woo et al.

JOURNAL OF VIROLOGY (2005)

添加到收藏夹

Article Multidisciplinary Sciences

A previously undescribed coronavirus associated with respiratory disease in humans

RAM Fouchier et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

添加到收藏夹

Article Biochemistry & Molecular Biology

Identification of a new human coronavirus

L van der Hoek et al.

NATURE MEDICINE (2004)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.