期刊
JOURNAL OF ULTRASOUND IN MEDICINE
卷 -, 期 -, 页码 -出版社
WILEY
DOI: 10.1002/jum.16252
关键词
breast cancer; microcalcifications; shear wave elastography; superb microvascular imaging; ultrasonography
The study aimed to investigate the role of superb microvascular imaging (SMI) and shear wave elastography (SWE) in predicting malignancy and invasiveness of isolated microcalcifications (MC) visualized by ultrasonography (US). The results showed that adding SMI and SWE to the sonographic evaluation can improve the accuracy of US-guided biopsy, help target the invasive part of the lesion, and avoid underestimation of core biopsy.
Objectives-The aim of this study was to investigate the role of superb microvascular imaging (SMI) and shear wave elastography (SWE) in the prediction of malignancy and invasiveness of isolated microcalcifications (MC) that can be visualized by ultrasonography (US). Material and Methods-Sixty-seven women with MC, who were considered suspicious on mammography were evaluated. Only those lesions that could be visualized by US and presented as non-mass lesion were included. They were evaluated by B-mode US, SMI, and SWE before US-guided core-needle biopsy. B-mode US, SMI (vascular index (SMIvi)), and SWE (E-mean, E-ratio) findings were compared with histopathologic features. Results-Pathology confirmed 45 malignant (21 invasive and 24 in situ carcinomas) and 22 benign lesions. There was a statistically significant difference between malignant and benign groups in terms of size (P =.015), distortion (P =.028), cystic component (P <.001), E-mean (P <.001), E-ratio (P <.001), and SMIvi (P =.006). For differentiation of invasiveness E-mean (P =.002), E-ratio (P =.002), and SMIvi (P =.030) were statistically significant. According to ROC analysis E-mean (cut-off point at 38 kPa) was the most sensitive (78%) and the most specific (95%) value among four numeric parameters (size, SMI, E-mean, and E-ratio) with AUC = 0.895, PPV = 97%, and NPV = 68% in detecting malignancy. In the evaluation of invasiveness, the most sensitive (71.4%) method was SMI (cut-off point at 3.4) and the most specific (72%) method was E-mean (cut-off point at 91.5 kPa). Conclusion-Our study shows that adding SWE and SMI to the sonographic evaluation of MC would be an advantage for US-guided biopsy. Including suspicious areas according to SMI and SWE in the sampling area can help target the invasive part of the lesion and avoid underestimation of core biopsy.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据