4.2 Article

Prehospital tranexamic acid is associated with a dose-dependent decrease in syndecan-1 after trauma: A secondary analysis of a prospective randomized trial

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Critical Care Medicine

The effect of tranexamic acid dosing regimen on trauma/hemorrhagic shock-related glycocalyx degradation and endothelial barrier permeability: An in vitro model

Michael Carge et al.

Summary: Early administration of TXA protects against degradation of endothelial glycocalyx, reduces increased permeability and the development of a fibrinolytic phenotype. This results in decreased neutrophil adherence and transmigration, leading to reduced vascular leakiness.

JOURNAL OF TRAUMA AND ACUTE CARE SURGERY (2022)

Article Critical Care Medicine

The effect of prostacyclin infusion on markers of endothelial activation and damage in mechanically ventilated patients with SARS-CoV-2 infection

Martin Vigstedt et al.

Summary: The study found that prostacyclin infusion resulted in a significant decrease in endothelial glycocalyx shedding at 24 hours, suggesting a protective effect on the endothelium, which may be related to the observed reduction in organ failure.

JOURNAL OF CRITICAL CARE (2022)

Article Critical Care Medicine

Prehospital synergy: Tranexamic acid and blood transfusion in patients at risk for hemorrhage

Andrew-Paul Deeb et al.

Summary: The study aimed to determine whether the use of prehospital packed red blood cells (pRBC) and tranexamic acid (TXA) could improve survival in injured patients at risk of hemorrhage. The results showed that the resuscitation group receiving prehospital pRBC+TXA had a significant reduction in 30-day mortality compared to other groups.

JOURNAL OF TRAUMA AND ACUTE CARE SURGERY (2022)

Article Multidisciplinary Sciences

Lipidomic signatures align with inflammatory patterns and outcomes in critical illness

Junru Wu et al.

Summary: Alterations in lipid metabolism and circulating lipid species have been reported in patients with acute critical illness. Here the authors show that selective rise in systemic phosphatidylethanolamine levels is a common feature of critical illness that associates with worse clinical outcomes.

NATURE COMMUNICATIONS (2022)

Article Critical Care Medicine

Endotheliopathy is associated with slower liberation from mechanical ventilation: a cohort study

Martin Schonemann-Lund et al.

Summary: Endotheliopathy biomarkers in acute respiratory failure are associated with lower rates of liberation from mechanical ventilation, hypoxemia at ICU admission, and 30-day all-cause mortality.

CRITICAL CARE (2022)

Article Medicine, General & Internal

Trauma-induced coagulopathy

Ernest E. Moore et al.

Summary: Trauma-induced coagulopathy describes alterations in hemostasis that can result in both uncontrolled bleeding and hypercoagulation, leading to venous thromboembolism and multiple organ failure.

NATURE REVIEWS DISEASE PRIMERS (2021)

Article Surgery

Early Prehospital Tranexamic Acid Following Injury Is Associated With a 30-day Survival Benefit A Secondary Analysis of a Randomized Clinical Trial

Shimena R. Li et al.

Summary: The study analyzed the timing and benefits of prehospital TXA administration in injured patients, finding that giving TXA within 1 hour post-injury is associated with lower 30-day mortality, reduced incidence of multiple organ failure, and decreased transfusion requirements.

ANNALS OF SURGERY (2021)

Article Cell Biology

Article Multi-omic analysis in injured humans: Patterns align with outcomes and treatment responses

Junru Wu et al.

Summary: Trauma is a major cause of death and morbidity worldwide. The analysis of a longitudinal multi-omic dataset from severely injured humans revealed systemic stormpatterns and consumption patterns, as well as two human injury response endotypes. Prehospital thawed plasma is found to rescue traumatic brain injury patients of one endotype, with Ubiquitin carboxy-terminal hydrolase L1 (UCHL1) identified as the most predictive circulating biomarker.

CELL REPORTS MEDICINE (2021)

Article Critical Care Medicine

Protective/reparative cytokines are suppressed at high injury severity in human trauma

Jinman Cai et al.

Summary: The study revealed that severe injuries are associated with the suppression of certain cytokines known for their tissue protection and regeneration effects, which correlates with adverse clinical outcomes. Thus, the relationship between injury severity and inflammatory mediators diverges with increasing ISS.

TRAUMA SURGERY & ACUTE CARE OPEN (2021)

Article Critical Care Medicine

Characterization of unexpected survivors following a prehospital plasma randomized trial

Danielle S. Gruen et al.

JOURNAL OF TRAUMA AND ACUTE CARE SURGERY (2020)

Article Medicine, Research & Experimental

Prehospital plasma is associated with distinct biomarker expression following injury

Danielle S. Gruen et al.

JCI INSIGHT (2020)

Review Hematology

Trauma-induced coagulopathy: The past, present, and future

Lucy Z. Kornblith et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2019)

Editorial Material Medicine, General & Internal

CRASH-3: a win for patients with traumatic brain injury

Andrew P. Cap

LANCET (2019)

Article Critical Care Medicine

Lung Repair and Regeneration in ARDS Role of PECAM1 and Wnt Signaling

Jesus Villar et al.

Article Critical Care Medicine

The temporal response and mechanism of action of tranexamic acid in endothelial glycocalyx degradation

Mark E. Diebel et al.

JOURNAL OF TRAUMA AND ACUTE CARE SURGERY (2018)

Editorial Material Medicine, General & Internal

Tranexamic acid: is it about time?

David J. Dries

LANCET (2018)

Review Immunology

Innate immune responses to trauma

Markus Huber-Lang et al.

NATURE IMMUNOLOGY (2018)

Review Medicine, General & Internal

Hemorrhagic Shock

Jeremy W. Cannon

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Article Critical Care Medicine

The temporal response and mechanism of action of tranexamic acid in endothelial glycocalyx degradation

Mark E. Diebel et al.

JOURNAL OF TRAUMA AND ACUTE CARE SURGERY (2018)

Article Medicine, General & Internal

Prehospital Plasma during Air Medical Transport in Trauma Patients at Risk for Hemorrhagic Shock

J. L. Sperry et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Article Critical Care Medicine

Prehospital plasma resuscitation associated with improved neurologic outcomes after traumatic brain injury

Matthew C. Hernandez et al.

JOURNAL OF TRAUMA AND ACUTE CARE SURGERY (2017)

Article Critical Care Medicine

Early tranexamic acid administration ameliorates the endotheliopathy of trauma and shock in an in vitro model

Lawrence N. Diebel et al.

JOURNAL OF TRAUMA AND ACUTE CARE SURGERY (2017)

Article Medicine, Research & Experimental

Tranexamic acid in bleeding trauma patients: an exploration of benefits and harms

Ian Roberts et al.

TRIALS (2017)

Article Critical Care Medicine

Prehospital plasma resuscitation associated with improved neurologic outcomes after traumatic brain injury

Matthew C. Hernandez et al.

JOURNAL OF TRAUMA AND ACUTE CARE SURGERY (2017)

Article Critical Care Medicine

Early tranexamic acid administration ameliorates the endotheliopathy of trauma and shock in an in vitro model

Lawrence N. Diebel et al.

JOURNAL OF TRAUMA AND ACUTE CARE SURGERY (2017)

Review Cell Biology

PECAM-1: regulator of endothelial junctional integrity

Jamie R. Privratsky et al.

CELL AND TISSUE RESEARCH (2014)

Review Hematology

PECAM-1: A multi-functional molecule in inflammation and vascular biology

Abigail Woodfin et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2007)