4.7 Article

Disheveled3 enhanced EMT and cancer stem-like cells properties via Wnt/beta-catenin/c-Myc/SOX2 pathway in colorectal cancer

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Biochemistry & Molecular Biology

Heterogeneity and dynamic of EMT through the plasticity of ribosome and mRNA translation

Chloe Morin et al.

Summary: Growing evidence suggests that translation and its translational machinery play a crucial role in establishing and maintaining physiological and pathological biological processes. This review examines the involvement of translational control, translational machinery, and ribosome biogenesis in different types of epithelial-to-mesenchymal transition (EMT), from embryonic and adult physiological to pathological contexts. The authors discuss the potential of integrated translational control and machinery to depict the heterogeneity and dynamics of EMT programs.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2022)

Article Oncology

Clinical management of metastatic colorectal cancer in the era of precision medicine

Fortunato Ciardiello et al.

Summary: This review summarizes the progress in the clinical management of patients with metastatic colorectal cancer (mCRC) in the era of precision medicine. Molecular stratification, based on the current treatment algorithm, has been a significant step towards implementing more effective therapeutic approaches. Integrating tumor gene alterations with tumor and microenvironment gene and protein expression profiling, host immune competence, and applying dynamic changes to precision medicine-based continuum of care, could lead to the identification of individual prognostic and predictive parameters for choosing the most appropriate therapeutic program for each patient.

CA-A CANCER JOURNAL FOR CLINICIANS (2022)

Review Biochemistry & Molecular Biology

Wnt signaling in colorectal cancer: pathogenic role and therapeutic target

Hui Zhao et al.

Summary: The Wnt signaling pathway is a complex network involved in embryonic development and cancer, as well as normal physiological processes. It plays a crucial role in cell differentiation and the progression of colorectal cancer.

MOLECULAR CANCER (2022)

Article Pharmacology & Pharmacy

STAT3-EMT axis in tumors: Modulation of cancer metastasis, stemness and therapy response

Mehrdokht Sadrkhanloo et al.

Summary: Epithelial-to-mesenchymal transition (EMT) mechanism is responsible for tumor metastasis and inhibition of this process improves prognosis. STAT3 signaling is shown to promote EMT-mediated cancer migration and invasion, and its inhibition suppresses cancer metastasis and improves therapy response.

PHARMACOLOGICAL RESEARCH (2022)

Article Cell Biology

Triple-negative breast cancer metastasis involves complex epithelial-mesenchymal transition dynamics and requires vimentin

Eloise M. Grasset et al.

Summary: Triple-negative breast cancer (TNBC) is an aggressive subtype associated with early metastatic recurrence and worse patient outcomes. Our study demonstrates the important and complex role of epithelial-mesenchymal transition (EMT) programs during TNBC metastasis. We observed the presence of a large population of hybrid epithelial-mesenchymal cells in TNBC tumors, which express both epithelial and mesenchymal characteristics and promote invasion in vitro. The mesenchymal marker vimentin promotes invasion and represses metastatic outgrowth. We also identified distinct patterns of EMT transcription factor utilization during invasion and colony formation. Our findings suggest a sequential activation of multiple EMT molecular programs during the metastatic cascade. Longitudinal single-cell RNA analysis detected three different EMT-related molecular patterns, indicating a complex spectrum of epithelial, hybrid E/M, and mesenchymal cell states within metastases. Our results highlight the heterogeneity and multiple molecular strategies for successful distant organ colonization in TNBC.

SCIENCE TRANSLATIONAL MEDICINE (2022)

Article Cell Biology

Reciprocal SOX2 regulation by SMAD1-SMAD3 is critical for anoikis resistance and metastasis in cancer

Zainab Shonibare et al.

Summary: Growth factors in tumor environments, specifically the TGF-0 superfamily growth factors BMP and TGF-0/activin, play a crucial role in regulating cell survival and metastasis. This study uncovers the opposing effects of BMPs and TGF-0/activin on the expression of SOX2, a key signaling node, impacting anchorage-independent cell survival in ovarian cancers. Repression of SOX2 by BMPs leads to reduced tumor burden and improved survival, while TGF-0 and activin A promote SOX2 expression and anchorage-independent survival.

CELL REPORTS (2022)

Article Medicine, Research & Experimental

Single-cell transcriptomics reveals the regulative roles of cancer associated fibroblasts in tumor immune microenvironment of recurrent osteosarcoma

Xin Huang et al.

Summary: This study investigated the tumor microenvironment (TME) and gene expression pattern of primary and recurrent osteosarcoma (OS) at the single-cell level. Cancer-associated fibroblasts (CAFs) were found to have a higher infiltrating level in recurrent OS, and enrichment in the epithelial-mesenchymal transition (EMT) pathway. CAFs showed increased expression of LOX, which might lead to EMT and poor prognosis of OS. LOX was found to regulate the function of CAFs and macrophage polarization to remodel the tumor immune microenvironment. Targeting LOX of CAFs showed promising efficacy in remodeling TME and treating recurrent OS.

THERANOSTICS (2022)

Article Medicine, Research & Experimental

N6-methyladenosine-mediated LDHA induction potentiates chemoresistance of colorectal cancer cells through metabolic reprogramming

Kun Zhang et al.

Summary: The study reveals that the METTL3/LDHA axis-induced glucose metabolism could be a potential therapeutic target to overcome 5-FU resistance in CRC cells.

THERANOSTICS (2022)

Article Medicine, Research & Experimental

SIRPγ-expressing cancer stem-like cells promote immune escape of lung cancer via Hippo signaling

Chuan Xu et al.

Summary: Signal regulatory protein gamma (SIRP gamma) determines the properties and immune evasiveness of cancer stem-like cells (CSLCs) in a small population of lung adenocarcinoma (LUAD) cancer cells. SIRP gamma activates the Hippo/YAP signaling pathway to release cytokines and stimulate CD47 expression in tumor cells, inhibiting their phagocytosis. Targeting SIRP gamma can inhibit CSLC phenotypes and promote tumor phagocytosis, making it an immune and CSLC-targeting strategy for lung cancer therapy.

JOURNAL OF CLINICAL INVESTIGATION (2022)

Review Biochemistry & Molecular Biology

Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities

Jiaqi Liu et al.

Summary: This article provides a comprehensive review of the Wnt/β-catenin pathway, including its origin, composition, function, and clinical trials. It also discusses the challenges and opportunities for developing small-molecule compounds targeting this signaling pathway in disease treatment.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2022)

Review Urology & Nephrology

WNT-β-catenin signalling - a versatile player in kidney injury and repair

Stefan J. Schunk et al.

Summary: The WNT-beta-catenin pathway plays a critical role in kidney development and repair, with transient activation aiding in tissue regeneration after acute kidney injury, but uncontrolled signalling can lead to kidney fibrosis and other kidney diseases.

NATURE REVIEWS NEPHROLOGY (2021)

Article Cell Biology

Distinct contributions of partial and full EMT to breast cancer malignancy

Fabiana Lueoend et al.

Summary: EMT is a transient and reversible process where cancer cells transition between epithelial and mesenchymal states. Partial EMT cells contribute to metastasis and chemoresistance, while full EMT cells fail to colonize the lungs but are enriched in recurrent tumors post-chemotherapy.

DEVELOPMENTAL CELL (2021)

Article Oncology

Promotion of epithelial-mesenchymal transformation by hepatocellular carcinoma-educated macrophages through Wnt2b/β-catenin/c-Myc signaling and reprogramming glycolysis

Yu Jiang et al.

Summary: Wnt2b in hepatocellular carcinoma cells promotes M2 polarization of TAMs and activates glycolysis in HCC-TAMs through the Wnt2b/beta-catenin/c-Myc signaling pathway, leading to enhanced EMT, proliferation, and migration of HCC. Targeting Wnt2b or beta-catenin with CpG ODN downregulates glycolysis, inhibits M2 polarization, and reverses the tumor-promoting effects of TAMs in vitro and in vivo, suggesting therapeutic potential for HCC therapy.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2021)

Review Oncology

lncRNA involvement in cancer stem cell function and epithelial-mesenchymal transitions

Evan M. McCabe et al.

Summary: The epithelial to mesenchymal transition (EMT) is a cellular process crucial in embryogenesis, where cancer stem cells (CSCs) play a role by differentiating and undergoing EMT. Long noncoding RNAs (lncRNAs) also have a role in CSCs and EMT, with the potential to serve as biomarkers and therapeutic targets in cancer progression.

SEMINARS IN CANCER BIOLOGY (2021)

Review Oncology

Resistance to anti-EGFR therapies in metastatic colorectal cancer: underlying mechanisms and reversal strategies

Jing Zhou et al.

Summary: The article discusses the resistance mechanisms to anti-EGFR monoclonal antibodies, as well as diverse approaches to reverse resistance to this therapy.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2021)

Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

Article Oncology

Dissecting miRNA signature in colorectal cancer progression and metastasis

Xiangjie Huang et al.

Summary: Colorectal cancer is the third most common cancer globally with a poor 5-year survival rate. MicroRNAs play a crucial role in the progression and metastasis of CRC by regulating target genes. This review provides updated information on tumor suppressive and oncogenic miRNAs, circulatory miRNAs, and the causes of dysregulated miRNAs in CRC, as well as their important functions in drug resistance.

CANCER LETTERS (2021)

Article Oncology

Heat Shock Protein 90 Triggers Multi-Drug Resistance of Ovarian Cancer via AKT/GSK3β/β-Catenin Signaling

Lan Yin et al.

Summary: The study revealed that overexpression of Hsp90 in multi-drug resistant ovarian cancer cells can be reduced to increase sensitivity to paclitaxel and cisplatin, decrease drug-induced apoptosis, and regulate the expressions of multidrug resistance proteins. Further, Hsp90 affects beta-catenin accumulation and transcriptional activity, contributing to multi-drug resistance through AKT/GSK3 beta signaling.

FRONTIERS IN ONCOLOGY (2021)

Review Oncology

EMT-associated microRNAs and their roles in cancer stemness and drug resistance

Guangtao Pan et al.

Summary: EMT is involved in various malignant behaviors of cancers such as proliferation, invasion, and metastasis; miRNAs play a crucial role in regulating EMT phenotype and influencing cancer stemness and drug resistance; understanding the relationship between EMT-associated miRNAs and cancer stemness/drug resistance is beneficial for both basic research and clinical treatment.

CANCER COMMUNICATIONS (2021)

Review Oncology

Management of BRAF-mutant metastatic colorectal cancer: a review of treatment options and evidence-based guidelines

A. Grothey et al.

Summary: Colorectal cancer remains a leading cause of cancer-related deaths globally, with the mutation in the BRAF gene, particularly the V600E substitution, affecting 10% of metastatic CRC patients and indicating a poor prognosis. Recent advancements in combination therapies targeting the MAPK pathway have shown promising results in treating BRAF V600E-mutated mCRC patients, offering new hope in the management of this subtype of cancer.

ANNALS OF ONCOLOGY (2021)

Article Biochemistry & Molecular Biology

Nuclear Dishevelled targets gene regulatory regions and promotes tumor growth

Isabel Castro-Piedras et al.

Summary: Recent studies have shown that DVL3 plays a critical role in mediating various cellular functions through regulation of multiple genes involved in developmental biology, antigen presentation, metabolism, chromatin remodeling, and tumorigenesis. DVL3 depletion has been shown to alter KMT2D binding to novel targets and change their epigenetic marks and mRNA levels.

EMBO REPORTS (2021)

Article Gastroenterology & Hepatology

CD47-Mediated Hedgehog/SMO/GLI1 Signaling Promotes Mesenchymal Stem Cell Immunomodulation in Mouse Liver Inflammation

Mingwei Sheng et al.

Summary: The CD47-SIRP alpha signaling pathway plays a crucial role in MSC-mediated immune regulation during sterile inflammatory liver injury. Activation of this pathway controls NEK7/NLRP3 activity through a direct interaction between Gli1 and NICD, which modulates the inflammatory response in MSC-immunotherapy.

HEPATOLOGY (2021)

Article Cell Biology

SOX2 promotes chemoresistance, cancer stem cells properties, and epithelial-mesenchymal transition by β-catenin and Beclin1/autophagy signaling in colorectal cancer

Yin Zhu et al.

Summary: The study elucidated the mechanisms by which SOX2 regulates ABCC2 in colorectal cancer, along with beta-catenin, Beclin1, and autophagy signaling, affecting chemoresistance, stemness, and EMT. Clinical analyses revealed a positive correlation between high ABCC2 and Beclin1 expression with SOX2, associated with poor prognosis in CRC patients. Xenograft models confirmed that inhibition of SOX2 expression and autophagy restrained tumor growth and chemoresistance in vivo.

CELL DEATH & DISEASE (2021)

Article Pharmacology & Pharmacy

HYD-PEP06 suppresses hepatocellular carcinoma metastasis, epithelial-mesenchymal transition and cancer stem cell-like properties by inhibiting PI3K/AKT and WNT/β-catenin signaling activation

Wei Tian et al.

Summary: HYD-PEP06 effectively inhibits the metastasis and EMT of hepatocellular carcinoma by suppressing the PI3K/AKT pathway and WNT/β-catenin signaling pathway, showing potential as a treatment agent.

ACTA PHARMACEUTICA SINICA B (2021)

Article Biochemistry & Molecular Biology

ZEB2 facilitates peritoneal metastasis by regulating the invasiveness and tumorigenesis of cancer stem-like cells in high-grade serous ovarian cancers

Yiying Li et al.

Summary: The study revealed that ZEB2 facilitates the invasive metastasis of EOC-CSLCs in HGSOC patients, and high ZEB2 expression is closely associated with metastasis rate and prognosis.

ONCOGENE (2021)

Review Biochemistry & Molecular Biology

Regulation of Dishevelled protein activity and stability by post-translational modifications and autophagy

Qiaoni Shi et al.

Summary: Dishevelled (Dvl/Dsh) is a key component of Wnt signaling, essential for development processes in multicellular organisms. It acts as a branch-point of both beta-catenin-dependent canonical and beta-catenin-independent noncanonical pathways, dynamically interacting with multiple proteins to modulate Wnt signaling. The regulation of Dvl activity, localization, and stability by post-translational modifications, aggregation, and autophagy impacts its function in both Wnt signaling and biological processes.

TRENDS IN BIOCHEMICAL SCIENCES (2021)

Review Oncology

WNT as a Driver and Dependency in Cancer

Marie J. Parsons et al.

Summary: The WNT signaling pathway plays a critical role in various cancer types, with distinct patterns of dysregulation and immune evasion mechanisms. Targeting the oncogenic effects of WNT signaling is a current focus of research in developing therapeutic strategies for cancer treatment.

CANCER DISCOVERY (2021)

Article Medicine, Research & Experimental

Targeting the αv integrin/TGF-β axis improves natural killer cell function against glioblastoma stem cells

Hila Shaim et al.

Summary: Glioblastoma stem cells (GSCs) in the aggressive brain cancer Glioblastoma multiforme (GBM) evade immune responses by impairing the function of tumor-infiltrating NK cells through a direct cell-to-cell contact mechanism mediated by alpha v integrin and TGF-β activation. Treatment with inhibitors of integrin or TGF-β signaling, or with TGFBR2 gene-edited allogeneic NK cells, prevents GSC-induced NK cell dysfunction and tumor growth, suggesting a potential therapeutic strategy for GBM.

JOURNAL OF CLINICAL INVESTIGATION (2021)

Review Oncology

Linking EMT programmes to normal and neoplastic epithelial stem cells

Arthur W. Lambert et al.

Summary: Epithelial stem cells play critical roles in tissue generation, maintenance, and repair, while cancer stem cells are implicated in the growth and recurrence of many carcinomas. The activation of epithelial-mesenchymal transition (EMT) is linked to the formation of both normal and neoplastic stem cells, but the mechanistic basis of this connection remains unclear. Understanding the elusive links between EMT programs and the stem cell state will advance our knowledge of normal stem cell biology and cancer pathogenesis.

NATURE REVIEWS CANCER (2021)

Article Medicine, Research & Experimental

EZH2 activates CHK1 signaling to promote ovarian cancer chemoresistance by maintaining the properties of cancer stem cells

Yiping Wen et al.

Summary: The study revealed that EZH2 plays a critical role in ovarian cancer stemness and chemo-resistance, with CHK1 being a target involved in CSC stemness regulated by EZH2. Clinical samples showed that high levels of EZH2 and CHK1 were associated with poorer prognosis and increased resistance to platinum drugs in ovarian cancer patients.

THERANOSTICS (2021)

Review Oncology

Insights into new mechanisms and models of cancer stem cell multidrug resistance

Y. Garcia-Mayea et al.

SEMINARS IN CANCER BIOLOGY (2020)

Review Oncology

SOX2 in development and cancer biology

Daniel Novak et al.

SEMINARS IN CANCER BIOLOGY (2020)

Review Pharmacology & Pharmacy

5-fluorouracil and other fluoropyrimidines in colorectal cancer: Past, present and future

Sona Vodenkova et al.

PHARMACOLOGY & THERAPEUTICS (2020)

Article Multidisciplinary Sciences

Single-molecule dynamics of Dishevelled at the plasma membrane and Wnt activation

Wenzhe Ma et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Review Cell Biology

EMT, MET, Plasticity, and Tumor Metastasis

Basil Bakir et al.

TRENDS IN CELL BIOLOGY (2020)

Review Oncology

Targeting the Wnt/β-catenin signaling pathway in cancer

Ya Zhang et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2020)

Article Oncology

TM4SF1 promotes EMT and cancer stemness via the Wnt/β-catenin/SOX2 pathway in colorectal cancer

Qiang Tang et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2020)

Review Chemistry, Multidisciplinary

Cancer stem cell-targeted bio-imaging and chemotherapeutic perspective

Jiyou Han et al.

CHEMICAL SOCIETY REVIEWS (2020)

Review Biochemistry & Molecular Biology

Functional characterization of SOX2 as an anticancer target

Shizhen Zhang et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

Article Biochemistry & Molecular Biology

ASPM promotes prostate cancer stemness and progression by augmenting Wnt-Dvl-3-β-catenin signaling

Vincent C. Pai et al.

ONCOGENE (2019)

Review Gastroenterology & Hepatology

Global burden of colorectal cancer: emerging trends, risk factors and prevention strategies

NaNa Keum et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2019)

Review Gastroenterology & Hepatology

Gut microbiota in colorectal cancer: mechanisms of action and clinical applications

Sunny H. Wong et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2019)

Article Multidisciplinary Sciences

TRIB3 supports breast cancer sternness by suppressing FOXO1 degradation and enhancing SOX2 transcription

Jin-mei Yu et al.

NATURE COMMUNICATIONS (2019)

Article Biotechnology & Applied Microbiology

miR-145 Antagonizes SNAI1-Mediated Sternness and Radiation Resistance in Colorectal Cancer

Yun Zhu et al.

MOLECULAR THERAPY (2018)

Article Multidisciplinary Sciences

A molecular mechanism for Wnt ligand-specific signaling

Marie Eubelen et al.

SCIENCE (2018)

Article Biochemistry & Molecular Biology

Smac mimetic promotes glioblastoma cancer stem-like cell differentiation by activating NF-KB

A. Tchoghandjian et al.

CELL DEATH AND DIFFERENTIATION (2014)

Review Biochemistry & Molecular Biology

Wnt/β-Catenin Signaling and Disease

Hans Clevers et al.

Article Biochemistry & Molecular Biology

Signaling crosstalk between TGFβ and Dishevelled/Par1b

A. Mamidi et al.

CELL DEATH AND DIFFERENTIATION (2012)

Article Developmental Biology

Dishevelled limits Notch signalling through inhibition of CSL

Giovanna M. Collu et al.

DEVELOPMENT (2012)

Article Genetics & Heredity

PrognoScan: a new database for meta-analysis of the prognostic value of genes

Hideaki Mizuno et al.

BMC MEDICAL GENOMICS (2009)