☆ 4.7 Article

Identification of Timm13 protein translocase of the mitochondrial inner membrane as a potential mediator of liver fibrosis based on bioinformatics and experimental verification

JOURNAL OF TRANSLATIONAL MEDICINE (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Chemistry, Multidisciplinary

Tetramethylpyrazine prevents liver fibrotic injury in mice by targeting hepatocyte-derived and mitochondrial DNA-enriched extracellular vesicles

Ya-Jing Li et al.

Summary: The study shows that Tetramethylpyrazine (TMP) can reduce liver damage and fibrosis by regulating communication between extracellular vesicles. TMP effectively improves liver diseases caused by carbon tetrachloride and acetaminophen, and prevents liver cell injury and activation of hepatic stellate cells.

ACTA PHARMACOLOGICA SINICA (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Nobiletin mitigates hepatocytes death, liver inflammation, and fibrosis in a murine model of NASH through modulating hepatic oxidative stress and mitochondrial dysfunction †

Shuyu Li et al.

Summary: The study demonstrated that nobiletin (NOB) effectively alleviated nonalcoholic steatohepatitis (NASH) and liver fibrosis by reducing hepatic oxidative stress and attenuating mitochondrial dysfunction. This suggests that NOB may be a promising agent for the treatment of NASH and liver fibrosis.

JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Serum-derived miR-574-5p-containing exosomes contribute to liver fibrosis by activating hepatic stellate cells

Xia Zhou et al.

Summary: This study found that the expression of miR-574-5p in serum exosomes is positively correlated with collagen deposition and HSC activation in liver tissues during liver fibrosis. Serum exosomes may activate HSC through the transfer of miR-574-5p during liver fibrosis.

MOLECULAR BIOLOGY REPORTS (2022)

添加到收藏夹

Article Oncology

Identification of GINS2 prognostic potential and involvement in immune cell infiltration in hepatocellular carcinoma

Zuyin Li et al.

Summary: GINS2 overexpression is associated with poor prognosis in hepatocellular carcinoma, possibly due to its involvement in cell cycle, DNA replication, and exhaustion of T lymphocytes.

JOURNAL OF CANCER (2022)

添加到收藏夹

Article Plant Sciences

Cajanus cajan ameliorated CCl4-induced oxidative stress in Wistar rats via the combined mechanisms of anti-inflammation and mitochondrial-membrane transition pore inhibition

Olajumoke Olufunlayo Nwaechefu et al.

Summary: The leaf extract of Cajanus cajan has a protective effect on CCl4-induced liver injury by inhibiting the opening of mitochondrial permeability transition pore, preventing intracellular oxidative stress, and suppressing inflammatory response, indicating its potential value in chemoprevention of liver injury.

JOURNAL OF ETHNOPHARMACOLOGY (2022)

添加到收藏夹

Article Surgery

TIMM13 as a prognostic biomarker and associated with immune infiltration in skin cutaneous melanoma (SKCM)

Sitong Zhou et al.

Summary: This study found that TIMM13 is highly expressed in cutaneous melanoma and is closely associated with sample type, subgroup, cancer stage, lymph node stage, and worse survival. Upregulation of TIMM13 is significantly related to immunoregulators, chemokines, and various immune cell types. The results suggest that TIMM13 may serve as a prognostic biomarker for cutaneous melanoma and be involved in regulating the tumor immune microenvironment.

FRONTIERS IN SURGERY (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Identification of a Gene Panel Predictive of Triple-Negative Breast Cancer Response to Neoadjuvant Chemotherapy Employing Transcriptomic and Functional Validation

Radhakrishnan Vishnubalaji et al.

Summary: This study identified gene signatures predictive of residual disease (RD) and pathological complete response (pCR) in triple-negative breast cancer (TNBC), which can be used to predict overall survival and relapse-free survival. These gene signatures have potential clinical implications.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

添加到收藏夹

Review Gastroenterology & Hepatology

Role of Cholesterol-Associated Steatohepatitis in the Development of NASH

Christian L. Horn et al.

Summary: The increasing prevalence of nonalcoholic fatty liver disease (NAFLD) and NAFLD-related cirrhosis in the United States and globally emphasizes the importance of understanding the mechanisms causing progression of hepatic steatosis to fibrosing steatohepatitis and cirrhosis. Accumulating evidence suggests that hepatic free cholesterol (FC) overload plays a key role in necroinflammation and fibrosis, contributing to the development and progression of nonalcoholic steatohepatitis (NASH).

HEPATOLOGY COMMUNICATIONS (2022)

添加到收藏夹

Article Nutrition & Dietetics

Dietary Protein From Different Sources Exerted a Great Impact on Lipid Metabolism and Mitochondrial Oxidative Phosphorylation in Rat Liver

Xuebin Shi et al.

Summary: The study showed that different sources of meat protein diets have varying long-term effects on liver metabolic enzymes in rats. Fish and pork protein diets upregulate genes involved in cholesterol synthesis and esterification, while chicken, pork, and beef protein diets are beneficial for cholesterol reverse transport and bile acid production.

FRONTIERS IN NUTRITION (2021)

添加到收藏夹

Article Oncology

PM2.5 promotes Drp1-mediated mitophagy to induce hepatic stellate cell activation and hepatic fibrosis via regulating miR-411

Zhong-Jian Wang et al.

Summary: The study found that PM2.5 induced HSC proliferation and fibrosis by increasing the levels of ACTA2, Collagen 1, TIMP1, and TGF-beta 1. PM2.5 also reduced miR-411 expression, leading to mitochondrial dynamics dysfunction, and promoted mitophagy in HSCs. Additionally, miR-411 played a regulatory role in PM2.5-induced mitophagy by targeting Drp1.

EXPERIMENTAL CELL RESEARCH (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Cellular and Molecular Targets of Nucleotide-Tagged Trithiolato-Bridged Arene Ruthenium Complexes in the Protozoan Parasites Toxoplasma gondii and Trypanosoma brucei

Nicoleta Anghel et al.

Summary: The study investigated a novel ruthenium complex conjugated to 9-(2-hydroxyethyl)-adenine as a potential treatment against Toxoplasma gondii and Trypanosoma brucei. Proteins binding to the complex were identified using differential affinity chromatography followed by shotgun-mass spectrometry. The complex induced distinct ultrastructural modifications in the mitochondrion of the parasites, showing promising potential as a new treatment option.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Multiple variants of the human presequence translocase motor subunit Magmas govern the mitochondrial import

Tejashree Pradip Waingankar et al.

Summary: Mitochondrial protein translocation is a complex process regulated by dedicated translocases on the outer and inner membranes. Magmas, a J-like protein subunit of the translocase of the inner membrane 23, can regulate human protein import by forming heterodimers with J-proteins. Additional Magmas variants in humans play a significant role in maximizing protein import under familial-linked pathological conditions.

JOURNAL OF BIOLOGICAL CHEMISTRY (2021)

添加到收藏夹

Article Parasitology

Artesunate alleviates schistosomiasis-induced liver fibrosis by downregulation of mitochondrial complex I subunit NDUFB8 and complex III subunit UQCRC2 in hepatic stellate cells

Shuang Shen et al.

Summary: This study demonstrated that ART alleviates liver fibrosis by downregulating HSC activity and suppressing the expression of NDUFB8 and UQCRC2 in mitochondria.

ACTA TROPICA (2021)

添加到收藏夹

Article Cell Biology

Enhanced Expression of microRNA-1273g-3p Contributes to Alzheimer's Disease Pathogenesis by Regulating the Expression of Mitochondrial Genes

So Hee Kim et al.

Summary: The research identified miR-1273g-3p as an AD-associated miRNA that is elevated in the CSF of early-stage AD patients and enhances Aβ production and mitochondrial impairments. Through a biotin-streptavidin pull-down assay, it was demonstrated that miR-1273g-3p primarily interacts with mitochondrial genes, leading to their downregulation. Target gene analysis showed reduced expression of TIMM13 in brain tissues from human AD patients, indicating that miR-1273g-3p plays a role in early AD pathogenesis.

CELLS (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Mitochondrial Dysfunction in Advanced Liver Disease: Emerging Concepts

Ingrid W. Zhang et al.

Summary: Mitochondria play a crucial role in providing cellular energy and their dysfunction can lead to various diseases. Due to the high mitochondrial content, liver diseases require special attention to mitochondrial function. Research on mitochondrial dysfunction should start by defining the specific dysfunctions to be investigated.

FRONTIERS IN MOLECULAR BIOSCIENCES (2021)

添加到收藏夹

Letter Gastroenterology & Hepatology

Activation of cGAS/STING pathway upon TDP-43-mediated mitochondrial injury may be involved in the pathogenesis of liver fibrosis

Hui Yong et al.

LIVER INTERNATIONAL (2021)

添加到收藏夹

Article Medicine, Research & Experimental

Periplaneta americana extract ameliorates lipopolysaccharide-induced liver injury by improving mitochondrial dysfunction via the AMPK/PGC-1α signaling pathway

Wei Shi et al.

Summary: The study showed that XML can suppress mitochondrial dysfunction induced by LPS by activating the AMPK/PGC-1alpha signaling pathway, alleviating inflammation, oxidative stress, and mitochondrial dysfunction in AML12 cells induced by LPS. However, the addition of compound C and XML to LPS-induced AML12 cells resulted in aggravated cell injury.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2021)

添加到收藏夹

Article Oncology

Identification of significant immune-related genes for epilepsy via bioinformatics analysis

Xiaodan Luo et al.

Summary: The study revealed that immune-related genes such as CXCL1 play a significant role in epilepsy by regulating immune cell infiltration. The immune cell infiltration pattern in epilepsy patients differs significantly, contributing to a better understanding of the immune regulatory mechanisms in epilepsy.

ANNALS OF TRANSLATIONAL MEDICINE (2021)

添加到收藏夹

Article Medicine, General & Internal

MitoQ inhibits hepatic stellate cell activation and liver fibrosis by enhancing PINK1/parkin- mediated mitophagy

Shi-Ying Dou et al.

Summary: MitoQ inhibits HSC activation and alleviates hepatic fibrosis by enhancing PINK1/parkin-mediated mitophagy.

OPEN MEDICINE (2021)

添加到收藏夹

Review Medicine, Research & Experimental

Mechanisms of liver fibrosis and its role in liver cancer

Debanjan Dhar et al.

EXPERIMENTAL BIOLOGY AND MEDICINE (2020)

添加到收藏夹

Article Genetics & Heredity

Functional analysis of a novel mutation in the TIMM8A gene that causes deafness-dystonia-optic neuronopathy syndrome

Addison Neighbors et al.

MOLECULAR GENETICS & GENOMIC MEDICINE (2020)

添加到收藏夹

Article Genetics & Heredity

Role of the translocase of the mitochondrial inner membrane in the import of tRNAs into mitochondria in Trypanosoma brucei

Muhammad Younas Khan Barozai et al.

GENE (2020)

添加到收藏夹

Article Gastroenterology & Hepatology

Alleviation of hepatic fibrosis and autophagy via inhibition of transforming growth factor-β1/Smads pathway through shikonin

Tong Liu et al.

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2019)

添加到收藏夹

Article Genetics & Heredity

The mitochondrial translocase of the inner membrane PaTim54 is involved in defense response and longevity in Podospora anserina

Alex Mercier et al.

FUNGAL GENETICS AND BIOLOGY (2019)

添加到收藏夹

Article Environmental Sciences

Genome-wide interaction study of gene-by-occupational exposures on respiratory symptoms

Xiang Zeng et al.

ENVIRONMENT INTERNATIONAL (2019)

添加到收藏夹

Review Biochemistry & Molecular Biology

Liver fibrosis: Direct antifibrotic agents and targeted therapies

Detlef Schuppan et al.

MATRIX BIOLOGY (2018)

添加到收藏夹

Article Biochemistry & Molecular Biology

Acylglycerol Kinase Mutated in Sengers Syndrome Is a Subunit of the TIM22 Protein Translocase in Mitochondria

Milena Vukotic et al.

MOLECULAR CELL (2017)

添加到收藏夹

Article Multidisciplinary Sciences

The liver-enriched lnc-LFAR1 promotes liver fibrosis by activating TGFβ and Notch pathways

Kun Zhang et al.

NATURE COMMUNICATIONS (2017)

添加到收藏夹

Review Toxicology

Strategies to prevent and reverse liver fibrosis in humans and laboratory animals

Rong-Jane Chen et al.

ARCHIVES OF TOXICOLOGY (2015)

添加到收藏夹

Article Oncology

PBK/TOPK mediates geranylgeranylation signaling for breast cancer cell proliferation

Xiaoyan Dou et al.

CANCER CELL INTERNATIONAL (2015)

添加到收藏夹

Article Cell Biology

Tumor suppressor long non-coding RNA, MT1DP is negatively regulated by YAP and Runx2 to inhibit FoxA1 in liver cancer cells

Wenjun Yu et al.

CELLULAR SIGNALLING (2014)

添加到收藏夹

Article Biochemical Research Methods

Early Targets of miR-34a in Neuroblastoma

Pasqualino De Antonellis et al.

MOLECULAR & CELLULAR PROTEOMICS (2014)

添加到收藏夹

Review Immunology

Liver fibrosis and repair: immune regulation of wound healing in a solid organ

Antonella Pellicoro et al.

NATURE REVIEWS IMMUNOLOGY (2014)

添加到收藏夹

Article Biochemical Research Methods

Low-molecular-mass secretome profiling identifies C-C motif chemokine 5 as a potential plasma biomarker and therapeutic target for nasopharyngeal carcinoma

Shih-Jie Lin et al.

JOURNAL OF PROTEOMICS (2013)

添加到收藏夹

Article Biochemistry & Molecular Biology

Protein Translocase of Mitochondrial Inner Membrane in Trypanosoma brucei

Ujjal K. Singha et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

添加到收藏夹

Article Toxicology

Effect of dental amalgam on gene expression profiles in rat cerebrum, cerebellum, liver and kidney

Yoshifumi Takahashi et al.

JOURNAL OF TOXICOLOGICAL SCIENCES (2012)

添加到收藏夹

Article Neurosciences

Molecular genetics of a patient with Mohr-Tranebjaerg syndrome due to a new mutation in the DDPI gene

Jose Rafael Blesa et al.

NEUROMOLECULAR MEDICINE (2007)

添加到收藏夹

Article Biochemistry & Molecular Biology

Differential protein distributions define two sub-compartments of the mitochondrial inner membrane in yeast

Christian A. Wurm et al.

FEBS LETTERS (2006)

添加到收藏夹

Article Biochemistry & Molecular Biology

The calcium-binding aspartate/glutamate carriers, citrin and aralar1, are new substrates for the DDP1/TIMM8a-TIMM13 complex

K Roesch et al.

HUMAN MOLECULAR GENETICS (2004)

添加到收藏夹

Article Biochemistry & Molecular Biology

Import of small Tim proteins into the mitochondrial intermembrane space

T Lutz et al.

EMBO JOURNAL (2003)

添加到收藏夹

Article Cell Biology

The role of the Tim8p-Tim13p complex in a conserved import pathway for mitochondrial polytopic inner membrane proteins

SP Curran et al.

JOURNAL OF CELL BIOLOGY (2002)

添加到收藏夹

Article Biochemistry & Molecular Biology

The C66W mutation in the deafness dystonia peptide 1 (DDP1) affects the formation of functional DDP1•TIM13 complexes in the mitochondrial intermembrane space

S Hofmann et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

添加到收藏夹

Article Biochemistry & Molecular Biology

Human deafness dystonia syndrome is caused by a defect in assembly of the DDP1/TIMM8a-TIMM13 complex

K Roesch et al.

HUMAN MOLECULAR GENETICS (2002)

添加到收藏夹

Article Biochemistry & Molecular Biology

Role of the deafness dystonia peptide 1 (DDP1) in import of human Tim23 into the inner membrane of mitochondria

U Rothbauer et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)

添加到收藏夹

Article Biochemistry & Molecular Biology

The role of the TIM8-13 complex in the import of Tim23 into mitochondria

SA Paschen et al.

EMBO JOURNAL (2000)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.