Determining the degree of crystallization of aripiprazole during cold crystallization using thermo-optical analysis and differential scanning calorimetry

The full characteristic of the crystallization process of aripiprazole crystal is given. Our research reveals that a degree of crystallinity calculated from the analyses of data of light intensity passing through the sample (Thermo-Optical Analysis based on Polarized Light Microscopy-POM), the Canny edge detection algorithm, and Differential Scanning Calorimetry-DSC, are in good agreement. The parameters of Avrami model, the dimensionality of the crystal growth, and the characteristic crystallization temperature, obtained from POM and DSC methods coincide. The obtained values of the Avrami exponent n suggest that the crystal growth is three-dimensional.

Automated summary

The study presents a comprehensive characterization of the crystallization process of aripiprazole crystal. Results show that the degree of crystallinity calculated from light intensity data analysis, edge detection algorithm, and DSC are in agreement. The parameters of Avrami model, crystal growth dimensionality, and crystallization temperature obtained from POM and DSC methods coincide. The Avrami exponent n suggests three-dimensional crystal growth.