Physiological measures and anatomical correlates of subthalamic deep brain stimulation effect on gait in Parkinson's disease

We examined whether conflicting visual and non-visual information leads to gait abnormalities and how the subthalamic deep brain stimulation (STN DBS) influences gait dysfunction in Parkinson's disease (PD). We used a motion capture system to measure the kinematics of the lower limbs during treadmill walking in immersive virtual reality. The visual information provided in the virtual reality paradigm was modulated to create a mismatch between the optic-flow velocity of the visual scene and the walking speed on the treadmill. In each mismatched condition, we calculated the step duration, step length, step phase, step height, and asymmetries. The key finding of our study was that mismatch between treadmill walking speed and the optic-flow velocity did not consistently alter gait parameters in PD. We also found that STN DBS improved the PD gait pattern by changing the stride length and step height. The effects on phase and left/right asymmetry were not statistically significant. The DBS parameters and location also determined its effects on gait. Statistical effects on stride length and step height were noted when the DBS volume of activated tissue (VTA) was in the dorsal aspect of the subthalamus. The statistically significant effects of STN DBS was present when VTA significantly overlapped with MR tractogrphically measured motor and pre-motor hyperdirect pathways. In summary, our results provide novel insight into ways for controlling walking behavior in PD using STN DBS.

Automated summary

We investigated the impact of conflicting visual and non-visual information on gait abnormalities and explored how subthalamic deep brain stimulation (STN DBS) affects gait dysfunction in Parkinson's disease (PD). By using a motion capture system in immersive virtual reality, we measured the lower limb kinematics during treadmill walking. Our findings showed that the mismatch between optic-flow velocity and treadmill walking speed did not consistently alter gait parameters in PD. However, STN DBS improved PD gait pattern by modifying stride length and step height.