期刊
JOURNAL OF THE NEUROLOGICAL SCIENCES
卷 449, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.jns.2023.120669
关键词
Multiple sclerosis (MS); Optical coherence tomography (OCT); Vision; Peripapillary retinal nerve fiber layer; Optic neuritis
This study investigated the utility and durability of optical coherence tomography (OCT)-derived peripapillary retinal nerve fiber layer (pRNFL) and ganglion cell+inner plexiform layer (GCIPL) thickness inter-eye differences (IEDs) as markers for identifying optic nerve lesions in people with multiple sclerosis (PwMS). The results demonstrated longitudinal stability of pRNFL and GCIPL IEDs, reinforcing the role of OCT in demonstrating optic nerve lesions.
Introduction: Optical coherence tomography (OCT)-derived peripapillary retinal nerve fiber layer (pRNFL) and ganglion cell+inner plexiform layer (GCIPL) thickness inter-eye differences (IEDs) are robust measurements for identifying clinical history acute ON in people with MS (PwMS). This study investigated the utility and durability of these measures as longitudinal markers to identify optic nerve lesions.Methods: Prospective, multi-center international study of PwMS (with/without clinical history of ON) and healthy controls. Data from two sites in the International MS Visual System Consortium (IMSVISUAL) were analyzed. Mixed-effects models were used to compare inter-eye differences based on MS and acute ON history. Results: Average age of those with MS (n = 210) was 39.1 +/- 10.8 and 190 (91%) were relapsing-remitting. Fiftynine (28.1%) had a history of acute unilateral ON, while 9/210 (4.3%) had >1 IB episode. Median follow-up between OCT scans was 9 months. By mixed-effects modeling, IEDs were stable between first and last visits within groups for GCIPL for controls (p = 0.18), all PwMS (p = 0.74), PwMs without ON (p = 0.22), and PwMS with ON (p = 0.48). For pRNFL, IEDs were within controls (p = 0.10), all PwMS (p = 0.53), PwMS without ON history (p = 0.98), and PwMS with history of ON (p = 0.81). Conclusion: We demonstrated longitudinal stability of pRNFL and GCIPL IEDs as markers for optic nerve lesions in PwMS, thus reinforcing the role for OCT in demonstrating optic nerve lesions.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据