相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。In-Depth Characterization of Acidic Variants Induced by Metal- Catalyzed Oxidation in a Recombinant Monoclonal Antibody
Yi Yang et al.
ANALYTICAL CHEMISTRY (2023)
Detailed Analytical Characterization of a Bispecific IgG1 CrossMab Antibody of the Knob-into-Hole Format Applying Various Stress Conditions Revealed Pronounced Stability
Ingrid Grunert et al.
ACS OMEGA (2022)
3D-LC-MS with 2D Multimethod Option for Fully Automated Assessment of Multiple Attributes of Monoclonal Antibodies Directly from Cell Culture Supernatants
Liesa Verscheure et al.
ANALYTICAL CHEMISTRY (2022)
High-throughput multiplex analysis of mAb aggregates and charge variants by automated two-dimensional size exclusion-cation exchange chromatography coupled to mass spectrometry
Giulia Lambiase et al.
JOURNAL OF CHROMATOGRAPHY A (2022)
Direct coupling of size exclusion chromatography and mass spectrometry for the characterization of complex monoclonal antibody products
Amarande Murisier et al.
JOURNAL OF SEPARATION SCIENCE (2022)
Multiattribute Monitoring of Charge-Based Heterogeneity of Recombinant Monoclonal Antibodies Using 2D HIC-WCX-MS
Deepika Sarin et al.
ANALYTICAL CHEMISTRY (2022)
Multiattribute Monitoring of Charge-Based Heterogeneity of Recombinant Monoclonal Antibodies Using 2D HIC-WCX-MS
Deepika Sarin et al.
ANALYTICAL CHEMISTRY (2022)
Native LC-MS for capturing quality attributes of biopharmaceuticals on the intact protein level
Florian Fussl et al.
CURRENT OPINION IN BIOTECHNOLOGY (2021)
Automated mass spectrometry multi-attribute method analyses for process development and characterization of mAbs
Yvonne Ehwang Song et al.
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES (2021)
Towards a simple on-line coupling of ion exchange chromatography and native mass spectrometry for the detailed characterization of monoclonal antibodies
Amarande Murisier et al.
JOURNAL OF CHROMATOGRAPHY A (2021)
Multiattribute Monitoring of Antibody Charge Variants by Cation-Exchange Chromatography Coupled to Native Mass Spectrometry
Markus Haberger et al.
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY (2021)
Identification of critical chemical modifications by size exclusion chromatography of stressed antibody-target complexes with competitive binding
Rachel Liuqing Shi et al.
MABS (2021)
Multi-dimensional LC-MS: the next generation characterization of antibody-based therapeutics by unified online bottom-up, middle-up and intact approaches
Julien Camperi et al.
ANALYST (2021)
Integrating Intact Mass Analysis and Middle-Down Mass Spectrometry Approaches to Effectively Characterize Trastuzumab and Adalimumab Structural Heterogeneity
Wenwen Zhu et al.
JOURNAL OF PROTEOME RESEARCH (2021)
Separation of monoclonal antibody charge variants using cation exchange chromatography: Resins and separation conditions optimization
Shu-Ying Jing et al.
SEPARATION AND PURIFICATION TECHNOLOGY (2020)
Bridging size and charge variants of a therapeutic monoclonal antibody by two-dimensional liquid chromatography
Zhi Chen et al.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS (2020)
Impact of mAb Aggregation on Its Biological Activity: Rituximab as Case Study
Rohit Bansal et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2020)
Impact of the column on effluent pH in cation exchange pH gradient chromatography, a practical study
Evelin Farsang et al.
JOURNAL OF CHROMATOGRAPHY A (2020)
Hyphenation of strong cation exchange chromatography to native mass spectrometry for high throughput online characterization of charge heterogeneity of therapeutic monoclonal antibodies
Fengfei Ma et al.
MABS (2020)
Coupling Mixed-Mode Size Exclusion Chromatography with Native Mass Spectrometry for Sensitive Detection and Quantitation of Homodimer Impurities in Bispecific IgG
Yuetian Yan et al.
ANALYTICAL CHEMISTRY (2019)
Rapid charge variant analysis of monoclonal antibodies to support lead candidate biopharmaceutical development
Anne Trappe et al.
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES (2018)
Charge variants characterization of a monoclonal antibody by ion exchange chromatography coupled on-line to native mass spectrometry: Case study after a long-term storage at+5 °C
Y. Leblanc et al.
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES (2017)
Comprehensive study on the effects of sodium and potassium additives in size exclusion chromatographic separations of protein biopharmaceuticals
Alexandre Goyon et al.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS (2017)
Forced degradation of recombinant monoclonal antibodies: A practical guide
Christine Nowak et al.
MABS (2017)
Nanoparticle Analysis by Online Comprehensive Two-Dimensional Liquid Chromatography combining Hydrodynamic Chromatography and Size-Exclusion Chromatography with Intermediate Sample Transformation
Bob W. J. Pirok et al.
ANALYTICAL CHEMISTRY (2017)
Rapid characterization of biotherapeutic proteins by size-exclusion chromatography coupled to native mass spectrometry
Markus Haberger et al.
MABS (2016)
Determination of critical quality attributes for monoclonal antibodies using quality by design principles
Nadja Alt et al.
BIOLOGICALS (2016)
Emerging Strategies for Developing Next-Generation Protein Therapeutics for Cancer Treatment
James R. Kintzing et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2016)
Development of a quantitative mass spectrometry multi-attribute method for characterization, quality control testing and disposition of biologics
Richard S. Rogers et al.
MABS (2015)
Mass spectrometry for the biophysical characterization of therapeutic monoclonal antibodies
Hao Zhang et al.
FEBS LETTERS (2014)
Chemical Modifications in Therapeutic Protein Aggregates Generated under Different Stress Conditions
Quanzhou Luo et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Structural properties of monoclonal antibody aggregates induced by freeze-thawing and thermal stress
Andrea Hawe et al.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2009)
Characterization of the Photodegradation of a Human IgG1 Monoclonal Antibody Formulated as a High-Concentration Liquid Dosage Form
Pei Qi et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2009)
Structure and stability changes of human IgG1 Fc as a consequence of methionine oxidation
Dingjiang Liu et al.
BIOCHEMISTRY (2008)