☆ 4.8 Article

Small-Molecule Ferritin Degrader as a Pyroptosis Inducer

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Review Biochemistry & Molecular Biology

Persister cancer cells: Iron addiction and vulnerability to ferroptosis

Raphae Rodriguez et al.

Summary: Ferroptosis is a unique type of non-apoptotic cell death that occurs due to the unrestrained peroxidation of phospholipids, resulting in the production of lethal oxygen radicals mediated by iron. It has been observed in various organisms, including mammals, where it can serve as a defense mechanism against pathogens and be utilized by T cells for effective killing of tumor cells. Conversely, ferroptosis is considered to be one of the main cell death mechanisms contributing to degenerative diseases. Recent studies suggest that certain cancers exhibit vulnerabilities to ferroptosis, particularly in dedifferentiating and persister cancer cells that are dependent on iron. Exploiting this dependence on iron may hold therapeutic benefits.

MOLECULAR CELL (2022)

添加到收藏夹

Review Biotechnology & Applied Microbiology

PROTAC targeted protein degraders: the past is prologue

Miklos Bekes et al.

Summary: Targeted protein degradation (TPD) is a new therapeutic modality that can tackle disease-causing proteins which are difficult to target with conventional small molecules. PROTAC molecules, utilizing the ubiquitin-proteasome system to degrade target proteins, has achieved clinical proof-of-concept and attracted significant industry activity. Future directions include identifying target classes suitable for TPD, expanding the use of ubiquitin ligases for precision medicine, and extending the modality beyond oncology.

NATURE REVIEWS DRUG DISCOVERY (2022)

添加到收藏夹

Article Chemistry, Medicinal

Ispinesib as an Effective Warhead for the Design of Autophagosome-Tethering Chimeras: Discovery of Potent Degraders of Nicotinamide Phosphoribosyltransferase (NAMPT)

Guoqiang Dong et al.

Summary: ATTEC-ispinesib has been identified as an effective warhead for designing autophagosome-tethering chimeras, and it has the potential for broad applications.

JOURNAL OF MEDICINAL CHEMISTRY (2022)

添加到收藏夹

Review Chemistry, Multidisciplinary

Discovery of small molecule ligands for the von Hippel-Lindau (VHL) E3 ligase and their use as inhibitors and PROTAC degraders

Claudia J. Diehl et al.

Summary: This article presents the journey towards the design of small-molecule ligands binding to VHL, emphasizing the importance of high-quality ligands for PROTAC development and highlighting key findings and lessons learned.

CHEMICAL SOCIETY REVIEWS (2022)

添加到收藏夹

Review Chemistry, Multidisciplinary

Proteolysis-targeting chimera (PROTAC) delivery system: advancing protein degraders towards clinical translation

Yu Chen et al.

Summary: Proteolysis Targeting Chimeras (PROTACs) have the potential to revolutionize the healthcare industry by degrading target proteins. However, inadequate delivery to the target site is one of the main challenges for PROTACs. The integration of PROTACs and delivery systems is being explored to enhance their in vivo performance.

CHEMICAL SOCIETY REVIEWS (2022)

添加到收藏夹

Review Oncology

Targeting ferroptosis as a vulnerability in cancer

Guang Lei et al.

Summary: This article provides an overview of the importance and potential of ferroptosis in cancer research, summarizes the mechanisms of ferroptosis induction and defense, analyzes its roles and mechanisms in tumor suppression and tumor immunity, and explores therapeutic strategies targeting ferroptosis in cancer.

NATURE REVIEWS CANCER (2022)

添加到收藏夹

Review Chemistry, Multidisciplinary

E3 ligase ligand chemistries: from building blocks to protein degraders

Izidor Sosic et al.

Summary: Proteolysis-targeting chimeras (PROTACs) have shown great therapeutic potential and usefulness as molecular biology tools in recent years. These compounds induce targeted protein degradation by forming a ternary complex and leading to E3 ligase-mediated ubiquitination and proteasomal degradation. The field of PROTAC has grown substantially due to advancements in the discovery of non-peptidic E3 ligase ligands. Expanding the range of E3 ligands could contribute to broadening the scope of targeted protein degradation. This review focuses on the chemistry aspect of PROTAC design and serves as a blueprint for future research in this complex field.

CHEMICAL SOCIETY REVIEWS (2022)

添加到收藏夹

Article Environmental Sciences

Revealing the toxicity of dimethyl phthalate (DMP) to the oxygen-carrying function of red blood cells (RBCs): The iron release mechanism

Zhenxing Chi et al.

Summary: Phthalic acid esters pose harm to human health by affecting the oxygen-carrying function of red blood cells. High doses of DMP were found to reduce Hb content and increase granulocyte content, while in vitro experiments demonstrated an increase in iron release with DMP concentration. Vitamin C and E were observed to reduce iron release induced by DMP through oxidative stress.

CHEMOSPHERE (2021)

添加到收藏夹

Review Biotechnology & Applied Microbiology

Channelling inflammation: gasdermins in physiology and disease

Xing Liu et al.

Summary: Gasdermins have been identified as mediators of inflammatory cell death known as pyroptosis, forming cell membrane pores upon activation to release pro-inflammatory cytokines. They play important roles in autoimmune and inflammatory diseases, infectious diseases, deafness, and cancer, with potential for novel therapeutic avenues.

NATURE REVIEWS DRUG DISCOVERY (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Semiconducting polymer nano-PROTACs for activatable photo-immunometabolic cancer therapy

Chi Zhang et al.

Summary: Proteolysis targeting chimeras (PROTACs) offer an alternative way to modulate protein homeostasis for cancer therapy, but existing PROTACs may have uncontrollable protein degradation and off-target side effects. This study presents a semiconducting polymer nano-PROTAC (SPNpro) with phototherapeutic and activatable protein degradation abilities for photo-immunometabolic cancer therapy. SPNpro can generate singlet oxygen under NIR photoirradiation to eradicate tumor cells and activate protein degradation specifically in response to a cancer biomarker, enhancing tumor immunogenicity.

NATURE COMMUNICATIONS (2021)

添加到收藏夹

Article Pharmacology & Pharmacy

Discovery of an orally active VHL-recruiting PROTAC that achieves robust HMGCR degradation and potent hypolipidemic activity in vivo

Guoshun Luo et al.

Summary: The study developed a compound using PROTAC technology that successfully degrades HMGCR and demonstrated the possibility of oral administration. This compound showed potent HMGCR degradation and cholesterol reduction in a mouse model, offering a promising strategy for treating hyperlipidemia and associated diseases.

ACTA PHARMACEUTICA SINICA B (2021)

添加到收藏夹

Article Oncology

Dietary Fats High in Linoleic Acids Impair Antitumor T-cell Responses by Inducing E-FABP-Mediated Mitochondrial Dysfunction

Rong Jin et al.

Summary: The study found that dietary oils high in linoleic acid (LA) can promote mammary tumor growth by impairing anti-tumor T-cell responses. Inhibiting E-FABP activity may represent a novel strategy to enhance T-cell function in the prevention and treatment of obesity-associated cancers.

CANCER RESEARCH (2021)

添加到收藏夹

Article Biotechnology & Applied Microbiology

A mutant T1 lipase homology modeling, and its molecular docking and molecular dynamics simulation with fatty acids

Xiaoli Qin et al.

Summary: This study investigated the interactions between Mut-T1 lipase and various fatty acids through molecular docking and molecular dynamics simulation. The results showed that Mut-T1 lipase had lower binding affinity for shorter-chain caprylic acid, but the complex remained stable during simulation, with decreasing solvent accessible surface area as the chain length of the fatty acid increased.

JOURNAL OF BIOTECHNOLOGY (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Structure-Based Design of a Macrocyclic PROTAC

Andrea Testa et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Maintaining Iron Homeostasis Is the Key Role of Lysosomal Acidity for Cell Proliferation

Ross A. Weber et al.

MOLECULAR CELL (2020)

添加到收藏夹

Review Cell Biology

The caspase-3/GSDME signal pathway as a switch between apoptosis and pyroptosis in cancer

Mingxia Jiang et al.

CELL DEATH DISCOVERY (2020)

添加到收藏夹

Editorial Material Cell Biology

SLC3A2/CD98hc, autophagy and tumor radioresistance: a link confirmed

David Digomann et al.

AUTOPHAGY (2019)

添加到收藏夹

Article Oncology

A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo

Longchuan Bai et al.

CANCER CELL (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

The chemical basis of ferroptosis

Marcus Conrad et al.

NATURE CHEMICAL BIOLOGY (2019)

添加到收藏夹

Review Chemistry, Multidisciplinary

Emerging Strategies of Cancer Therapy Based on Ferroptosis

Zheyu Shen et al.

ADVANCED MATERIALS (2018)

添加到收藏夹

Review Endocrinology & Metabolism

Palmitic and Oleic Acid: The Yin and Yang of Fatty Acids in Type 2 Diabetes Mellitus

Xavier Palomer et al.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2018)

添加到收藏夹

Article Pharmacology & Pharmacy

Harnessing albumin as a carrier for cancer therapies

Ella N. Hoogenboezem et al.

ADVANCED DRUG DELIVERY REVIEWS (2018)

添加到收藏夹

Article Cell Biology

Tom20 senses iron-activated ROS signaling to promote melanoma cell pyroptosis

Bo Zhou et al.

CELL RESEARCH (2018)

添加到收藏夹

Article Multidisciplinary Sciences

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

Yupeng Wang et al.

NATURE (2017)

添加到收藏夹

Review Biotechnology & Applied Microbiology

Targeting iron metabolism in drug discovery and delivery

Bart J. Crielaard et al.

NATURE REVIEWS DRUG DISCOVERY (2017)

添加到收藏夹

Article Chemistry, Multidisciplinary

Unsaturated Long-Chain Fatty Acids Are Preferred Ferritin Ligands That Enhance Iron Biomineralization

Serena Zanzoni et al.

CHEMISTRY-A EUROPEAN JOURNAL (2017)

添加到收藏夹

Article Chemistry, Multidisciplinary

Modular PROTAC Design for the Degradation of Oncogenic BCR-ABL

Ashton C. Lai et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2016)

添加到收藏夹

Article Chemistry, Multidisciplinary

Solid microparticles based on chitosan or methyl-β-cyclodextrin: A first formulative approach to increase the nose-to-brain transport of deferoxamine mesylate

Giovanna Rassu et al.

JOURNAL OF CONTROLLED RELEASE (2015)

添加到收藏夹

Article Biochemistry & Molecular Biology

Catalytic in vivo protein knockdown by small-molecule PROTACs

Daniel P. Bondeson et al.

NATURE CHEMICAL BIOLOGY (2015)

添加到收藏夹

Article Cell Biology

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

Jose Pedro Friedmann Angeli et al.

NATURE CELL BIOLOGY (2014)

添加到收藏夹

Review Biochemistry & Molecular Biology

Unearthing the secrets of mitochondrial ROS and glutathione in bioenergetics

Ryan J. Mailloux et al.

TRENDS IN BIOCHEMICAL SCIENCES (2013)

添加到收藏夹

Review Oncology

Iron and cancer: more ore to be mined

Suzy V. Torti et al.

NATURE REVIEWS CANCER (2013)

添加到收藏夹

Article Chemistry, Medicinal

The co-crystal structure of ubiquitin carboxy-terminal hydrolase L1 (UCHL1) with a tripeptide fluoromethyl ketone (Z-VAE(OMe)-FMK)

Christopher W. Davies et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2012)

添加到收藏夹

Article Biochemistry & Molecular Biology

Ferritin couples iron and fatty acid metabolism

Weiming Bu et al.

FASEB JOURNAL (2012)

添加到收藏夹

Review Hematology

Ferritin for the clinician

Mary Ann Knovich et al.

BLOOD REVIEWS (2009)

添加到收藏夹

Review Pharmacology & Pharmacy

Albumin as Fatty Acid Transporter

Ger J. van der Vusse

DRUG METABOLISM AND PHARMACOKINETICS (2009)

添加到收藏夹

Article Chemistry, Medicinal

N-benzylisatin sulfonamide analogues as potent caspase-3 inhibitors:: Synthesis, in vitro activity, and molecular modeling studies

WH Chu et al.

JOURNAL OF MEDICINAL CHEMISTRY (2005)

添加到收藏夹

Article Biochemistry & Molecular Biology

Computational approach to solvent-free synthesis of ethyl oleate using Candida rugosa and Candida antarctica B lipases.: I.: Interfacial activation and substrate (ethanol, oleic acid) adsorption

ML Foresti et al.

BIOMACROMOLECULES (2004)

添加到收藏夹

Article Biochemistry & Molecular Biology

Binding of Thermomyces (Humicola) lanuginosa lipase to the mixed micelles of cis-parinaric acid/NaTDC - Fluorescence resonance energy transfer and crystallographic study

S Yapoudjian et al.

EUROPEAN JOURNAL OF BIOCHEMISTRY (2002)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.