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Introducing Savie: A Biodegradable Surfactant Enabling Chemo-and Biocatalysis and Related Reactions in Recyclable Water

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AMER CHEMICAL SOC
DOI: 10.1021/jacs.2c13444

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Savie, derived from vitamin E and polysarcosine, is a biodegradable surfactant used in recyclable water for organic synthesis. It can be used in homogeneous catalysis, heterogeneous catalysis, and biocatalytic transformations, showing higher yields and eliminating the use of wastegenerating organic solvents.
Savie is a biodegradable surfactant derived from vitamin E and polysarcosine (PSar) developed for use in organic synthesis in recyclable water. This includes homogeneous catalysis (including examples employing only ppm levels of catalyst), heterogeneous catalysis, and biocatalytic transformations, including a multistep chemoenzymatic sequence. Use of Savie frequently leads to significantly higher yields than do conventional surfactants, while obviating the need for wastegenerating organic solvents. [GRAPHICS]

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