期刊
JOURNAL OF TRANSLATIONAL MEDICINE
卷 14, 期 -, 页码 -出版社
BMC
DOI: 10.1186/s12967-016-1000-z
关键词
Cancer; Stathmin; Drug target; Anticancer therapy; Molecular targeted therapy
资金
- Technology Research and Development Plan of Gansu Province [0912TCYA016]
Knowledge of the molecular mechanisms on malignant tumors is very critical for the development of new treatment strategies like molecularly targeted therapies. In last 5 years, many investigations suggest that stathmin is over-expressed in a variety of human malignant tumors, and potentially promotes the occurrence and development of tumors. Rather, down-regulation of stathmin can reduce cell proliferation, motility and metastasis and induce apoptosis of malignant tumors. Thus, a stathmin antagonist, such as a specific inhibitor (antibody, small molecule compound, peptide, or siRNA), may be a novel strategy of molecular targeted therapy. This review summarizes the research progress of recent 5 years on the role of stathmin in tumorigenesis, the molecular mechanisms and development of anti-stathmin treatment, which suggest that continued investigations into the function of stathmin in the tumorigenesis could lead to more rationally designed therapeutics targeting stathmin for treating human malignant tumors.
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