期刊
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
卷 32, 期 3, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.jstrokecerebrovasdis.2022.106974
关键词
cytochrome P450; genetics; intracerebral hemorrhage; polymorphism
资金
- Linyi Sci-ence and Technology Development Program, China [201919010]
This study found that CYP2C8 gene polymorphisms are associated with an increased risk of HICH and poor outcomes in the Han Chinese population.
Purpose: Many studies have shown that cytochrome P450 (CYP) gene polymor-phisms are usually associated with an increased risk of cardiovascular and cerebro-vascular diseases. To explore the association of CYP2C8 and CYP2J2 gene polymorphisms with hypertensive intracerebral hemorrhage (HICH) in the Han Chinese population. Methods: Forty HICH patients and 40 control subjects were recruited for this study. Two single nucleotide polymorphisms (SNP) (rs1058932, rs2275622) in the CYP2C8 gene and two SNPs (rs2271800, rs1155002) in the CYP2J2 gene were selected for genotyping by direct sequencing. Statistical analysis was applied to examine the effect of genetic variation on HICH. Results: We found that variant alleles of CYP2C8 rs1058932 (A) and rs2275622 (C) were both significantly associated with HICH, especially in females. We also found significant associations of CYP2C8 rs1058932 (A) and rs2275622 (C) variant alleles with poor outcomes in HICH patients, especially in males. Conclusions: CYP2C8 gene polymorphisms might increase the risk of HICH in the Han Chinese population and might lead to poor outcomes. This finding adds to the body of literature supporting novel thera-peutic strategies for HICH.
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