Comparison of calcifediol with vitamin D for prevention or cure of vitamin D deficiency

Vitamin D deficiency remains prevalent, with about 7% of the world's population living with severe vitamin D deficiency and about one third with mild deficiency. We compare the relative merits of calcifediol or 25-hydroxyvitamin D (25OHD) compared to vitamin D itself for supplementation as to prevent or cure vitamin D deficiency. The intestinal absorption of calcifediol is nearly 100% and thus higher than that of vitamin D itself. Moreover, calcifediol is absorbed by the intestinal cells and transported through the portal vein and thus immediately accessible to the circulation, while vitamin D is transported with chylomicrons through the lymph system. Therefore, in case of fat malabsorption or after bariatric surgery, calcifediol is much better absorbed in comparison with vitamin D itself. Serum 25OHD increases linearly with increasing doses of calcifediol, whereas serum 25OHD reaches a plateau when higher oral doses of vitamin D are used. Calcifediol, on a weight basis, is about 3 times more potent than vitamin D in subjects with mild vitamin D deficiency. This potency is even 6-8 times higher than vitamin D when baseline serum 25OHD is higher or when large doses are compared. In conclusion, calcifediol is an alternative option to correct vitamin D deficiency and may even be the preferred strategy in case of intestinal fat malabsorption, after bariatric surgery or in case of other conditions with suspected impaired 25-hydroxylase activity in the liver.

Automated summary

Vitamin D deficiency affects a significant portion of the world's population, with 7% having severe deficiency and one third having mild deficiency. This study compares the effectiveness of calcifediol or 25-hydroxyvitamin D (25OHD) versus vitamin D itself in preventing or treating deficiency. Calcifediol has higher absorption rates, is immediately accessible to the circulation, and is more potent than vitamin D, especially in cases of fat malabsorption or after bariatric surgery. It may be a preferred option for correcting deficiency in individuals with impaired liver 25-hydroxylase activity.