Salvage high-dose rate brachytherapy for myxofibrosarcoma of the brachium: a technical report

An 80-year-old male presented with T1N0M0 myxofibrosarcoma in or next to the humeral canal, which is located between the biceps and triceps of the right upper arm. Because the tumor was close to critical anatomical structures such as the brachial artery, median nerve and ulnar nerve, it was deemed impossible to perform limb-sparing surgery with an adequate resection margin. Therefore, preoperative external beam radiation therapy (EBRT) followed by limb-sparing surgery was offered. Magnetic resonance imaging taken after 40 Gy/20 fractions of EBRT showed an inadequate response, and limb-sparing surgery was not deemed possible at this point. Amputation of the right arm was offered, but the patient refused. Therefore, salvage high-dose-rate interstitial brachytherapy (HDR-ISBT) was offered. Under local anesthesia and sedation, 14 plastic needles were inserted, and 36 Gy in 6 fractions of HDR-ISBT was performed. Although radiation-induced incomplete paralysis of the median nerve was noted, no local progression or distant metastasis was found on the CT that was taken 2 years after the treatment.

Automated summary

An 80-year-old male presented with T1N0M0 myxofibrosarcoma in or next to the humeral canal. Preoperative external beam radiation therapy (EBRT) followed by limb-sparing surgery was initially offered but deemed impossible. Amputation was suggested but refused by the patient. Salvage high-dose-rate interstitial brachytherapy (HDR-ISBT) was performed, resulting in no local progression or distant metastasis after 2 years.