Barrier-environment interactions along the gut-brain axis and their influence on cognition and behaviour throughout the lifespan

Environment is known to substantially alter mental state and behaviour across the lifespan. Biological barriers such as the blood-brain barrier (BBB) and gut barrier (GB) are major hubs for communication of environmental information. Alterations in the structural, social and motor environment at different stages of life can influence function of the BBB and GB and their integrity to exert behavioural consequences. Importantly, each of these environmental components is associated with a distinct immune profile, glucocorticoid response and gut microbiome composition, creating unique effects on the BBB and GB. These barrier-environment interactions are sensitive to change throughout life, and positive or negative alterations at critical stages of development can exert long-lasting cognitive and behavioural consequences. Furthermore, because loss of barrier integrity is implicated in pathogenesis of mental disorders, the pathways of environmental influence represent important areas for understanding these diseases. Positive environments can be protective against stress- and age-related damage, raising the possibility of novel pharmacological targets. This review summarizes known mechanisms of environmental influence - such as social interactions, structural complexity and physical exercise - on barrier composition, morphology and development, and considers the outcomes and implications of these interactions in the context of psychiatric disorders.

Automated summary

The environment has a significant influence on mental states and behaviors, with biological barriers such as the blood-brain barrier and gut barrier serving as important channels for environmental information. Changes in the structural, social, and motor environment at different stages of life can affect the function and integrity of these barriers, leading to behavioral consequences. Each environmental component is associated with distinct immune profiles, glucocorticoid responses, and gut microbiome compositions, which have unique effects on the barriers. The interactions between barriers and the environment are sensitive to changes throughout life, and positive or negative alterations during critical developmental stages can have long-lasting cognitive and behavioral consequences. Understanding these pathways of environmental influence is important in understanding mental disorders and identifying potential pharmacological targets for protection and treatment. This review summarizes the mechanisms through which environmental factors such as social interactions, structural complexity, and physical exercise influence barrier composition, morphology, and development, and discusses the outcomes and implications of these interactions in psychiatric disorders.