Regenerating interest in pharmacotherapy for spinal cord injury

Summary: This study investigates the effects of C2SH on diaphragm muscle and transdiaphragmatic pressure, as well as the potential therapeutic effect of SPG302. The results show that immediate deficits in diaphragm EMG activity and transdiaphragmatic pressure occur after C2SH surgery, while treatment with SPG302 can enhance the recovery of diaphragm EMG and transdiaphragmatic pressure within 14 days post-surgery.

Summary: The study reviews the progress of a strategy involving therapeutic acute intermittent hypoxia (tAIH) to improve respiratory and non-respiratory motor function in people with neuromuscular disorders. Key areas of focus include greater mechanistic understanding, optimization of treatment protocols, identification of combinatorial treatments, assessment of long-term safety, and the development of a simple, safe and effective device for administering tAIH in clinical and home settings.

Summary: High spinal cord injuries (SCIs) often result in permanent diaphragmatic paralysis. This study investigated the effects of repetitive transcranial magnetic stimulation (rTMS) as a potential noninvasive therapeutic tool for enhancing respiratory function and reducing post-traumatic inflammation in cervical spinal cord injuries. The results suggest that chronic high-frequency rTMS can improve respiratory dysfunction, promote neuronal plasticity, and reduce harmful post-traumatic inflammatory processes. This therapy could be combined with other interventions to enhance outcomes.