Impact of cardiopulmonary bypass on cerebrovascular autoregulation assessed by ultrafast ultrasound imaging

Newborns with congenital heart disease undergoing cardiac surgery are at risk of neurodevelopmental impairment with limited understanding of the impact of intra-operative cardiopulmonary bypass (CPB), deep hypothermia and selective cerebral perfusion on the brain. We hypothesized that a novel ultrasound technique, ultrafast power Doppler (UPD), can assess variations of cerebral blood volume (CBV) in neonates undergoing cardiac surgery requiring CPB. UPD was performed before, during and after surgery in newborns with hypoplastic left heart syndrome undergoing a Norwood operation. We found that global CBV was not significantly different between patients and controls (P = 0.98) and between pre- and post-surgery (P = 0.62). UPD was able to monitor changes in CBV throughout surgery, revealing regional differences in CBV during hypothermia during which CBV correlated with CPB flow rate (R-2 = 0.52, P = 0.021). Brain injury on post-operative magnetic resonance imaging was observed in patients with higher maximum variation in CBV. Our findings suggest that UPD can quantify global and regional brain perfusion variation during neonatal cardiac surgery with this first intra-operative application demonstrating an association between CBV and CPB flow rate, suggesting loss of autoregulation. Therefore, the measurement of CBV by UPD could enable optimization of cerebral perfusion during cardiac surgery in neonates.

Automated summary

Newborns with congenital heart disease undergoing cardiac surgery are at risk of neurodevelopmental impairment. This study used ultrafast power Doppler to assess cerebral blood volume (CBV) variations in neonates with hypoplastic left heart syndrome during surgery. The results showed that global CBV did not differ significantly before and after surgery. However, regional differences in CBV were observed during hypothermia, and CBV was correlated with cardiopulmonary bypass (CPB) flow rate. Patients with higher CBV variation had brain injury on post-operative imaging. This suggests that the measurement of CBV using ultrafast power Doppler can optimize cerebral perfusion during neonatal cardiac surgery.