期刊
JOURNAL OF PHYSICAL CHEMISTRY B
卷 127, 期 11, 页码 2375-2380出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jpcb.2c09115
关键词
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Coherent Raman scattering microscopy utilizing bioorthogonal tagging approaches allows for targeted monitoring of small molecules in biological samples. To fully exploit this technique, a fast tunable laser is needed. The authors present a laser concept without moving parts for simultaneous acquisition of coherent anti-Stokes Raman scattering images at multiple Raman resonances.
Coherent Raman scattering microscopy utilizing bioorthogonal tagging approaches like isotope or alkyne labeling allows for a targeted monitoring of spatial distribution and dynamics of small molecules of interest in cells, tissues, and other complex biological matrices. To fully exploit this approach in terms of real-time monitoring of several Raman tags, e.g., to study drug uptake dynamics, extremely fast tunable lasers are needed. Here, we present a laser concept without moving parts and fully electronically controlled for the quasi-simultaneous acquisition of coherent anti-Stokes Raman scattering images at multiple Raman resonances. The laser concept is based on the combination of a low noise and spectrally narrow Fourier domain mode-locked laser seeding a compact four wave mixing-based high-power fiber-based optical parametric amplifier.
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