Molecularly imprinted polymers for the recognition of biomarkers of certain neurodegenerative diseases

The appearance of the biomarkers in body fluids like blood, urine, saliva, tears, etc. can be used for the iden-tification of many diseases. This article aimed to summarize the studies about electrochemical biosensors with molecularly imprinted polymers as sensitive and selective layers on the electrode to detect protein-based bio-markers of such neurodegenerative diseases as Alzheimer's disease, Parkinson's disease, and stress. The main attention in this article is focused on the detection methods of amyloid-beta oligomers and p-Tau which are representative biomarkers for Alzheimer's disease, alpha-synuclein as the biomarker of Parkinson's disease, and alpha-amylase and lysozyme as the biomarkers of stress using molecular imprinting technology. The research methods, the application of different electrodes, the influence of the polymers, and the established detection limits are reviewed and compared.

Automated summary

This article summarizes the studies on electrochemical biosensors with molecularly imprinted polymers as sensitive and selective layers for the detection of various disease biomarkers in body fluids such as urine, blood, saliva, and tears. The focus is on the use of molecular imprinting technology to detect protein-based biomarkers for neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and stress. The research methods, application of different electrodes, influence of polymers, and established detection limits are reviewed and compared.