Nickel-Catalyzed Alkylation of Oxindoles with Secondary Alcohols

Herein, we have demonstrated a simple nickel catalyzed C-3-selective alkylation of 2-oxindoles using a wide variety of secondary alkyl alcohols. As a special highlight, functionalization of the cholesterol derivative was reported. Control experiments, initial mechanistic studies, and deuterium-labeling experiments were performed for the alkylation process.

Automated summary

In this work, a simple nickel catalyzed C-3-selective alkylation of 2-oxindoles using various secondary alkyl alcohols has been demonstrated. Notably, the functionalization of the cholesterol derivative was reported. Control experiments, initial mechanistic studies, and deuterium-labeling experiments were conducted to support the results of the alkylation process.