Iron-Catalyzed C-C Bond Cleavage of Oximes for Direct Coupling of Benzothiazole in Water

An Fe-catalyzed coupling reaction between oxime ester and benzothiazole is described, which involves C-C bond cleavage of oxime ester via a single-electron transfer process. This iron catalytic system performed in water under mild reaction conditions offers a streamlined strategy to the construction of alkyl nitrile substituted benzothiazole derivatives. Application of this strategy for the synthesis of some key important compounds including 4-heterocyclic-3-arylbutanoic acid is also reported.

Automated summary

This article describes an Fe-catalyzed coupling reaction between oxime ester and benzothiazole, which involves C-C bond cleavage of oxime ester through a single-electron transfer process. This iron catalytic system performed in water under mild reaction conditions offers a streamlined strategy for the construction of alkyl nitrile substituted benzothiazole derivatives. The application of this strategy for the synthesis of some key important compounds, including 4-heterocyclic-3-arylbutanoic acid, is also reported.