期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 88, 期 6, 页码 3555-3566出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.2c02754
关键词
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We developed a photocatalyzed Giese reaction method that overcomes the substrate scope limitations and shows good functional groups tolerance, achieving high yields. The reaction mechanism involves in situ generation of an alkoxymethyl radical via single-electron oxidation of alpha-trimethylsilyl-substituted ethers.
We developed a photocatalyzed Giese reaction of various weakly activated Michael acceptors with a neutral silicon-based radical precursor and applied it at large-scale using a continuous flow reactor. The developed method successfully overcomes the substrate scope limitations of previous studies, shows good functional groups tolerance, and affords good to excellent yields. On the basis of mechanistic studies, we propose a reaction mechanism that involves an in situ generated alkoxymethyl radical via single-electron oxidation of alpha-trimethylsilyl-substituted ethers.
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