☆ 4.7 Article

An Approach to Functionally Embellished o-Alkynylbenzoates or Furan-3(2H)-ones from Diynones and DMAD: Controlled Divergence and Product Selectivity

JOURNAL OF ORGANIC CHEMISTRY (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Review Chemistry, Multidisciplinary

Green Chemistry in the Synthesis of Pharmaceuticals

Supratik Kar et al.

Summary: The principles of green chemistry can be effectively implemented in the green synthesis of pharmaceuticals by choosing solvent-free or green solvents, considering one-pot synthesis, multicomponent reactions, continuous processing, and process intensification approaches. Researchers and industries are actively pursuing green synthesis processes to control waste reduction and protect the environment.

CHEMICAL REVIEWS (2022)

添加到收藏夹

Article Chemistry, Organic

Tandem Michael-anti-Michael Addition-Mediated Orthogonal Strapping of Diynones: Regioselective Spirocyclopentannulation of Oxindoles and Pyrazolones and DFT Validation

Manas Jyoti Sarma et al.

Summary: An efficient protocol for the synthesis of orthogonally strap diynones through one pot transition-metal-free reaction has been developed. Insights into the regioselective tandem Michael-anti-Michael processes have been gleaned through DFT calculations.

JOURNAL OF ORGANIC CHEMISTRY (2022)

添加到收藏夹

Article Chemistry, Organic

Recursive Anion-Triggered Tandem Reactions of ortho-Bis-ynones: Tunable Synthesis of 1-Indenones and Cyclopenta[a]inden-8(2H)-ones

Anilkumar Gunnam et al.

Summary: The recursive anion-mediated activation of o-bis-ynones leads to the one-pot synthesis of 1-indenones, and further reactions result in the access to the embellished cyclopenta[a]inden-8(2H)-one core and its spiroannulated analogues.

JOURNAL OF ORGANIC CHEMISTRY (2022)

添加到收藏夹

Article Chemistry, Organic

In Situ-Generated Ammonia Mediates Deep Restructuring of o-Bis-Ynones through a Cascade Process: One-Pot Synthesis of 2-Azafluorenones

Alagesan Balasubramani et al.

Summary: A one-pot synthesis of 2-azaflorenones was discovered, involving the Michael addition, orthogonal aldol reaction, dehydrative isomerization, and a 6-endo-dig-cyclization cascade. The synthesis was triggered by in situ generated ammonia in the presence of a Cu(I) catalyst and its generality was investigated. The resulting 2-azaflorenones showed enhanced functionality in their core structure. Overall, this method allows for the formation of five new bonds in one pot and exhibits green and sustainable features.

JOURNAL OF ORGANIC CHEMISTRY (2022)

添加到收藏夹

Article Chemistry, Organic

Synthesis of γ-Pyrones and N-Methyl-4-pyridones via the Au Nanoparticle-Catalyzed Cyclization of Skipped Diynones in the Presence of Water or Aqueous Methylamine

Elisavet-Maria Zantioti-Chatzouda et al.

Summary: Au nanoparticles supported on TiO2 efficiently catalyze the hydration/6-endo cyclization of skipped diynones, leading to the formation of gamma-pyrones in aqueous dioxane. The reaction proceeds via triple bond activation, bypassing the formation of isomeric 3(2H)-furanones through a competing 5-exo cyclization pathway and the initial 1,3-transposition of the skipped diynones.

JOURNAL OF ORGANIC CHEMISTRY (2022)

添加到收藏夹

Review Chemistry, Organic

Domino Reactions through Recursive Anionic Cascades: The Advantageous Use of Nitronates

Saumitra Sengupta et al.

Summary: Recursive Anionic Cyclization (RAC) is a mechanistically distinct domino strategy that continues to grow. By using nitroalkanes as a source of recursive carbanions, it has created a unique operating space for generating molecular complexity and diversity. The recursive nitronate cyclization, based on a domino [5 C+1 C] cyclization strategy, allows rapid access to densely functionalized carbo- and heterocycles with multiple chiral centers and regio-, stereo- and enantioselectivity. Extension to aromatic domains, particularly through benzannulation reactions, has further expanded the operating space. The functional versatility of nitro group has also been leveraged for post-domino modifications, leading to total synthesis of various natural products.

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (2022)

添加到收藏夹

Review Chemistry, Multidisciplinary

Time and Pot Economy in Total Synthesis

Yujiro Hayashi

Summary: Chemists aim to synthesize organic molecules rapidly to study their physical or biological properties, with concepts like time economy, step economy, and redox economy being crucial. One-pot reactions are useful in shortening synthesis time, increasing yield, and reducing chemical waste. The successful synthesis of natural products and medicines highlights the importance of pot and time economy, with efficient strategies such as using organocatalysts in one-pot reactions.

ACCOUNTS OF CHEMICAL RESEARCH (2021)

添加到收藏夹

Article Chemistry, Organic

Phosphine-Catalyzed Synthesis of 3-Allyl-4-pyrones by the Tandem Reaction of Diynones and Allylic Alcohols

Ya-Fang Ye et al.

Summary: A simple and effective tandem reaction of diynones and allylic alcohols was developed to synthesize functionalized 3-allyl-4-pyrones in moderate to excellent yields. The protocol demonstrated broad substrate tolerance, high regioselectivity, and atom economy under a metal-free condition. Functional transformation of the products was also further studied.

JOURNAL OF ORGANIC CHEMISTRY (2021)

添加到收藏夹

Editorial Material Chemistry, Applied

Green Chemistry: A Framework for a Sustainable Future

Krishna N. Ganesh et al.

ORGANIC PROCESS RESEARCH & DEVELOPMENT (2021)

添加到收藏夹

Review Chemistry, Organic

Synthesis of 3(2H)-Furanones: A Review

Vishnu K. Omanakuttan et al.

Summary: The review provides a comprehensive overview of methods for synthesizing 3(2H)-furanones, which are core structures in numerous natural products and biologically active scaffolds. It categorizes the literature based on substitution patterns and emphasizes the generality and mechanistic rationalizations of each methodology. Additionally, it highlights total syntheses of natural products containing 3(2H)-furanones by focusing on heterocycle synthesis.

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (2021)

添加到收藏夹

Review Chemistry, Multidisciplinary

Mechanochemistry for Synthesis

Tomislav Friscic et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

添加到收藏夹

Article Chemistry, Organic

Base-Mediated Cyclopentannulation of Ynones with Amino Crotonates for Regio- and Stereoselective Synthesis of Pentafulvenes and Cyclopenta[c]quinolines

Attunuri Nagireddy et al.

JOURNAL OF ORGANIC CHEMISTRY (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

4,5-Diaryl 3(2H)Furanones: Anti-Inflammatory Activity and Influence on Cancer Growth

Dmitrii Semenok et al.

MOLECULES (2019)

添加到收藏夹

Review Chemistry, Applied

Tandem Reactions of Ynones: via Conjugate Addition of Nitrogen-, Carbon-, Oxygen-, Boron-, Silicon-, Phosphorus-, and Sulfur-Containing Nucleophiles

Yang Li et al.

ADVANCED SYNTHESIS & CATALYSIS (2019)

添加到收藏夹

Review Chemistry, Medicinal

Insights into the chemistry and therapeutic potential of furanones: A versatile pharmacophore

Asif Husain et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2019)

添加到收藏夹

Article Chemistry, Organic

Azidation vs [3+2]-cycloaddition: Chemoselective reaction of sodium azide towards o-alkynylaldehydes for the synthesis of N-heterocycles

Pradeep Kumar et al.

TETRAHEDRON LETTERS (2019)

添加到收藏夹

Review Chemistry, Multidisciplinary

Conjugated Ynones in Organic Synthesis

Carmen Najera et al.

CHEMICAL REVIEWS (2019)

添加到收藏夹

Article Chemistry, Organic

Lactonization of 2-Alkynylbenzoates for the Assembly of lsochromenones Mediated by BF3•Et2O

Xiang Zhang et al.

JOURNAL OF ORGANIC CHEMISTRY (2019)

添加到收藏夹

Article Chemistry, Multidisciplinary

Synthesis of carbonyl-bridged dibenzofulvalenes and related compounds by rhodium-catalyzed stitching reaction

Ryo Shintani et al.

CHEMICAL COMMUNICATIONS (2019)

添加到收藏夹

Article Chemistry, Multidisciplinary

Ethyl lactate as a renewable carbonyl source for the synthesis of diynones

Marta Solas et al.

GREEN CHEMISTRY (2019)

添加到收藏夹

Article Chemistry, Organic

Gold(I)-Catalyzed Oxidative Cascade Cyclization of 1,4-Diyn-3-ones for the Construction of Tropone-Fused Furan Scaffolds

Naoka Hamada et al.

ORGANIC LETTERS (2018)

添加到收藏夹

Article Chemistry, Organic

Metal free synthesis of quinoxalines from alkynes via a cascade process using TsNBr2

Debojit Hazarika et al.

TETRAHEDRON (2017)

添加到收藏夹

Article Chemistry, Applied

An Unexpected Domino Reaction of β-Keto Sulfones with Acetylene Ketones Promoted by Base: Facile Synthesis of 3(2H)-Furanones and Sulfonylbenzenes

Wei Tong et al.

ADVANCED SYNTHESIS & CATALYSIS (2017)

添加到收藏夹

Article Chemistry, Multidisciplinary

Gold-Catalyzed 1,3-Transposition of Ynones

Roohollah Kazem Shiroodi et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2014)

添加到收藏夹

Article Chemistry, Organic

A Combination of Copper(0) Powder and Selectfluor Enables Generation of Cationic Copper Species for Mild 1,2-Dicarbonylation of Alkynes

Wenxia Zhang et al.

SYNLETT (2013)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.