Photo- or Electrochemical Cyclization of Dienes with Diselenides to Access Seleno-Benzo[b]azepines

A cascadeselenylation/cyclization of dienes with diselenides hasbeen realized under visible-light irradiation or electrolysis conditions.Employing O-2 or electricity as a greenoxidant, this protocol provides a green and efficient method for anarray of biologically important seleno-benzo-[b]-azepinederivatives in moderate to good yields. The direct sunlight irradiationand gram-scale reaction render the approach practical and attractive.

Automated summary

A cascadeselenylation/cyclization of dienes with diselenides has been achieved under visible-light irradiation or electrolysis conditions. Employing O-2 or electricity as a green oxidant, this method offers a green and efficient approach for the synthesis of various biologically important seleno-benz-[b]-azepine derivatives in moderate to good yields. The use of direct sunlight irradiation and gram-scale reactions make this approach practical and attractive.