Dehydroxylative Sulfonylation of Alcohols

Article Chemistry, Multidisciplinary

Full-Spectrum Fluoromethyl Sulfonation via Modularized Multicomponent Coupling

Kejie Li et al.

Summary: Modular free-assembly construction of mono-, di-, and tri-fluoromethyl sulfones was achieved by combining halides, a sulfur dioxide surrogate, and halofluorocarbons. This method shows great potential and importance in drug discovery.

CCS CHEMISTRY (2022)

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Article Chemistry, Multidisciplinary

Expeditious and Efficient ortho-Selective Trifluoromethane-sulfonylation of Arylhydroxylamines

Yue Liu et al.

Summary: A metal- and oxidant-free method has been developed for the synthesis of versatile ortho-trifluoromethanesulfonylated anilines from arylhydroxylamines and trifluoromethanesulfinic chloride. The reaction proceeds smoothly with good yields and excellent ortho-selectivity, showcasing practical application potential in the synthesis of functional molecules.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2022)

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Article Chemistry, Organic

1,1,1,3,3,3-Hexafluoro-2-propanol (HFIP)-Assisted Catalyst-Free Sulfonation of Allylic Alcohols with Sulfinyl Amides

Zhen Luo et al.

Summary: A highly selective and catalyst-free sulfonation of allylic alcohols with sulfinyl amides has been achieved, providing a convenient way to synthesize various allylic sulfones under mild conditions. This novel reaction exhibits broad substrate scope and excellent functional group tolerance, and can also be scaled-up. In addition, sulfinyl amides have been found to act as powerful sulfur nucleophiles in this reaction. Moreover, the solvent 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP) plays a crucial role in allylic sulfonation.

ORGANIC LETTERS (2022)

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Article Chemistry, Physical

Visible-Light-Mediated Late-Stage Sulfonylation of Boronic Acids via N-S Bond Activation of Sulfonamides

Jingsong Zhen et al.

Summary: A visible-light-mediated late-stage arylation of N-S bonds in sulfonamides has been developed using readily available imines as sulfonyl radical source. This methodology characterized by broad substrate scope and simple reaction conditions also has high atom economy.

ACS CATALYSIS (2022)

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Article Chemistry, Organic

Temperature controlled di- and monosulfonylation of propargyl alcohols with sodium sulfinates: switchable access to (E)-allyl, vinyldisulfones and propargyl sulfones

Chang-Qing Liu et al.

Summary: A switchable di- and monosulfonylation reaction of propargyl alcohols with sodium sulfinates has been developed, leading to the successful synthesis of (E)-allyl, vinyldisulfones, and propargyl sulfones with good to excellent yields. This protocol has the advantages of using readily available starting materials, a broad substrate scope, and can be conducted in an air-atmosphere and under metal-free conditions.

ORGANIC CHEMISTRY FRONTIERS (2022)

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Article Chemistry, Multidisciplinary

Amine-Catalyzed Copper-Mediated C-H Sulfonylation of Benzaldehydes via a Transient Imine Directing Group

Joe Higham et al.

Summary: Transient directing groups (TDGs) combined with copper have been used for efficient C-H functionalization without additional steps for directing group introduction and removal. This method demonstrates high regioselectivity in the beta-C(sp(2))-H sulfonylation and gamma-(peri)-sulfonylation reactions of benzaldehydes and achieves through the use of catalytic beta-alanine and sulfinate salts, with copper fluoride serving as both the copper source and oxidant.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2022)

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Article Chemistry, Multidisciplinary

Carbene-Catalyzed Enantioselective Sulfonylation of Enone Aryl Aldehydes: A New Mode of Breslow Intermediate Oxidation

Rui Deng et al.

Summary: A novel carbene-catalyzed sulfonylation reaction between enone aryl aldehydes and sulfonyl chlorides has been disclosed, leading to the efficient installation of sulfone moieties. The NHC catalyst provides activation and stereoselectivity control on a very remote site of the enone aryl aldehyde substrates. Water plays a crucial role in modulating catalyst deactivation and reactivation routes involving reactions between NHC and sulfonyl chloride.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2022)

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Article Chemistry, Organic

Photoredox-Catalyzed?-Sulfonylation of Ketones from SulfurDioxide and Thianthrenium Salts

Fu-Sheng He et al.

Summary: This research developed a new photoredox-catalyzed reaction method, which can introduce various functionalized sulfonyl groups into ketones through the synthesis of easily accessible starting materials and good functional group compatibility. In addition, it is the first time that α-methylsulfonated ketones have been synthesized using methanol as the methyl source, which is an important industrial raw material.

ORGANIC LETTERS (2022)

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Article Chemistry, Multidisciplinary

Catalyst-Dependent Direct and Deoxygenative Coupling of Alcohols by Convergent Paired Electrolysis

Sheng Zhang et al.

Summary: This study presents an electrochemical approach for the direct coupling and deoxygenative coupling of alcohols with fluorenones, providing a new pathway for synthesizing high value products. The method features excellent functional-group tolerance, mild reaction conditions, and good scalability.

CCS CHEMISTRY (2022)

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Article Chemistry, Organic

Sulfonylation of Propargyl Alcohols with Sulfinamides for the Synthesis of Allenyl Sulfones

Fei-Fei Zou et al.

Summary: A regio- and chemoselective sulfonylation method was developed for the synthesis of multi-substituted allenyl sulfones using sulfinamides as the sulfonyl sources. The use of 1,1,1,3,3,3-hexafluoroisopropanol (HFIP) as the solvent enabled the transformation to proceed under mild conditions without the need for additional catalysts or oxidants.

JOURNAL OF ORGANIC CHEMISTRY (2022)

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Article Chemistry, Organic

Copper-Catalyzed Regio- and Stereoselective Sulfonylation of Alkynyl Imines with Sulfonyl Hydrazides: Access to (E)-β-Sulfonyl Enones

Rongxiang Chen et al.

Summary: A copper-catalyzed sulfonylation reaction of alkynyl imines with sulfonyl hydrazides has been developed, demonstrating excellent regio- and stereoselectivity and providing a series of (E)-β-sulfonyl enones in moderate to good yields. Mechanistic studies suggest that this strategy proceeds via a radical process.

JOURNAL OF ORGANIC CHEMISTRY (2022)

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Article Chemistry, Multidisciplinary

Access to chiral β-sulfonyl carbonyl compounds via photoinduced organocatalytic asymmetric radical sulfonylation with sulfur dioxide

Fu-Sheng He et al.

Summary: This study develops a photoinduced organocatalytic enantioselective radical reaction, which allows for the efficient synthesis of chiral beta-sulfonyl carbonyl compounds with high yield and excellent enantioselectivity.

CHEMICAL SCIENCE (2022)

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Article Chemistry, Multidisciplinary

Sulfonylation from sodium dithionite or thiourea dioxide

Fu-Sheng He et al.

Summary: The use of sodium dithionite and thiourea dioxide as sources of sulfonyl groups in recent synthetic reactions has become a research hotspot due to their alternative and complementary routes. These strategies offer mild conditions and broad substrate scopes with excellent functional group compatibility.

CHINESE CHEMICAL LETTERS (2021)

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Article Chemistry, Organic

Selenium-Catalyzed Trifluoromethylsulfinylation/Rearrangement of Allylic and Propargylic Alcohols: Access to Allylic and Allenic Triflones

Deng Zhu et al.

Summary: A novel selenium-catalyzed trifluoromethylsulfinylation/rearrangement reaction was developed for synthesizing triflones, delivering various substrates in moderate to excellent yields. The transformation involves an unusual [+SCF3] group disproportionation process, catalyzed in-situ by selenium using H2O as an oxygen source. The reaction features mild conditions, good substrate compatibility, and is transition-metal-free.

ORGANIC LETTERS (2021)

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Article Chemistry, Organic

Mild Base-Promoted Tandem Nucleophilic Substitution/ Decarboxylation/Hydroamination: Access to 3-Sulfonylindoles and 2-Methyleneindophenols

Guifang Chen et al.

Summary: An efficient method for constructing 3-sulfonylindoles and 2-methyleneindophenols via decarboxylative propargylation/hydroamination has been developed, using sodium sulfonates and phenols as the nucleophiles. The reaction features mild conditions, high chemoselectivity, and can be extended to other nucleophiles such as malonates, alcohols, and indoles. The broad substrate scope and scalability of this protocol make it practical for the synthesis of indole derivatives.

ORGANIC LETTERS (2021)

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Article Chemistry, Multidisciplinary

Electrochemically Enabled, Nickel-Catalyzed Dehydroxylative Cross-Coupling of Alcohols with Aryl Halides

Zijian Li et al.

Summary: This method utilizes alcohols and aryl bromides as coupling partners, combining anodic preparation and nickel catalysis to efficiently construct C(sp(2))-C(sp(3)) bonds. The nickel-catalyzed paired electrolysis reaction showcases a broad substrate scope suitable for the synthesis of multifunctional compounds.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2021)

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Article Chemistry, Medicinal

6-Halopyridylmethylidene Penicillin-Based Sulfones Efficiently Inactivate the Natural Resistance of Pseudomonas aeruginosa to β-Lactam Antibiotics

Juan C. Vazquez-Ucha et al.

Summary: Studies have shown that overproduction of chromosomal cephalosporinase AmpC is a major factor contributing to antimicrobial resistance in Pseudomonas aeruginosa. Specific compounds were found to improve the effectiveness of the antipseudomonal drug ceftazidime, indicating potential value in drug design for targeting AmpC enzymes.

JOURNAL OF MEDICINAL CHEMISTRY (2021)

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Article Multidisciplinary Sciences

Photocatalytic three-component asymmetric sulfonylation via direct C(sp3)-H functionalization

Shi Cao et al.

Summary: The study demonstrates the use of a dual asymmetric photocatalyst leading to the development of asymmetric sulfonylation involving direct functionalization of cycloalkanes, alkanes, toluene derivatives or ethers.

NATURE COMMUNICATIONS (2021)

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Article Chemistry, Organic

Desulfonylative Electrocarboxylation with Carbon Dioxide

Jun-Song Zhong et al.

Summary: The electrocarboxylation of organic halides is a well-investigated method for converting thermodynamically inert CO2 into carboxylic acids. By converting organic halides into sulfone derivatives, a highly efficient electrochemical desulfonylative carboxylation protocol has been developed, utilizing CO2 as the abundant C1 building block for the preparation of multifunctionalized carboxylic acids, including the NSAID ibuprofen, under mild reaction conditions.

JOURNAL OF ORGANIC CHEMISTRY (2021)

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Article Multidisciplinary Sciences

Metallaphotoredox-enabled deoxygenative arylation of alcohols

Zhe Dong et al.

Summary: Metal-catalysed cross-couplings are widely used for the formation of C-C bonds, but alkyl cross-couplings using alcohols as coupling partners remain relatively underdeveloped. A new method for direct deoxygenative cross-coupling of free alcohols has been developed, showing potential for a wide range of applications, including the pharmaceutical industry. This technology represents a general strategy for combining in situ alcohol activation with transition metal catalysis.

NATURE (2021)

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Article Chemistry, Organic

Copper-Mediated Cross-Coupling of Diazo Compounds with Sulfinates

Qian Wang et al.

Summary: The copper-mediated cross-coupling reaction between a diazo compound and a sodium alkane(arene)sulfinate results in the formation of a sulfone product. The effectiveness of the sulfinates in this reaction is determined by their nucleophilicity.

ORGANIC LETTERS (2021)

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Article Chemistry, Organic

Visible-Light-Catalyzed in Situ Denitrogenative Sulfonylation of Sulfonylhydrazones

Xiang Huang et al.

Summary: A photocatalyzed in situ denitrogenative sulfonylation of N-arylsulfonyl hydrazones has been developed, providing a low-carbon strategy to assemble arylalkyl sulfones in a stepwise denitrogenation/sulfonylation manner.

ORGANIC LETTERS (2021)

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Review Chemistry, Organic

Photoinduced Sulfonylation Reactions through the Insertion of Sulfur Dioxide

Shengqing Ye et al.

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (2020)

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Article Chemistry, Applied

Electrochemical Sulfonylation of Alkynes with Sulfonyl Hydrazides: A Metal- and Oxidant-Free Protocol for the Synthesis of Alkynyl Sulfones

Zu-Yu Mo et al.

ADVANCED SYNTHESIS & CATALYSIS (2020)

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Article Chemistry, Multidisciplinary

Dehydroxylative Trifluoromethylthiolation, Trifluoromethylation, and Difluoromethylation of Alcohols

Wei Zhang et al.

CHINESE JOURNAL OF CHEMISTRY (2020)

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Article Chemistry, Multidisciplinary

Sodium Dithionite-Mediated Decarboxylative Sulfonylation: Facile Access to Tertiary Sulfones

Yaping Li et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

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Review Chemistry, Organic

Recent Advances of Sulfonylation Reactions in Water

Li Wu et al.

CURRENT ORGANIC SYNTHESIS (2020)

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Article Chemistry, Multidisciplinary

Catalytic Decarboxylative Radical Sulfonylation

Jiayan He et al.

CHEM (2020)

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Review Chemistry, Multidisciplinary

Contribution of Organofluorine Compounds to Pharmaceuticals

Munenori Inoue et al.

ACS OMEGA (2020)

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Review Chemistry, Applied

Oxidative Sulfonylation of Multiple Carbon-Carbon bonds with Sulfonyl Hydrazides, Sulfinic Acids and their Salts

Olga M. Mulina et al.

ADVANCED SYNTHESIS & CATALYSIS (2020)

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Article Chemistry, Organic

Dehydroxylative Fluorination of Tertiary Alcohols

Wei Zhang et al.

ORGANIC LETTERS (2020)

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Article Chemistry, Organic

Reciprocal-Activation Strategy for Allylic Sulfination with Unactivated Allylic Alcohols

Peizhong Xie et al.

ORGANIC LETTERS (2020)

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Article Chemistry, Multidisciplinary

Alkyltriflones in the Ramberg-Backlund Reaction: An Efficient and Modular Synthesis of gem-Difluoroalkenes

Yuuki Maekawa et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)

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Article Chemistry, Multidisciplinary

Radical Dehydroxylative Alkylation of Tertiary Alcohols by Ti Catalysis

Hao Xie et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)

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Article Multidisciplinary Sciences

Current Contributions of Organofluorine Compounds to the Agrochemical Industry

Yuta Ogawa et al.

ISCIENCE (2020)

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Review Chemistry, Multidisciplinary

Recent advances in sulfonylation reactions using potassium/sodium metabisulfite

Shengqing Ye et al.

CHEMICAL COMMUNICATIONS (2020)

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Article Chemistry, Physical

MOF-Derived Subnanometer Cobalt Catalyst for Selective C-H Oxidative Sulfonylation of Tetrahydroquinoxalines with Sodium Sulfinates

Feng Xie et al.

ACS CATALYSIS (2019)

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Article Chemistry, Applied

Palladium-Catalyzed Regio- and Stereoselective Sulfonylation of Aryl Propiolates with Sulfonyl Hydrazides: Access to (E)-β-Aryl Sulfonyl Acrylates

Huanfeng Jiang et al.

ADVANCED SYNTHESIS & CATALYSIS (2019)

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Article Chemistry, Organic

Desulfonylative Arylation of Redox-Active Alkyl Sulfones with Aryl Bromides

Jonathan M. E. Hughes et al.

ORGANIC LETTERS (2019)

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Article Chemistry, Organic

Photoredox-Catalyzed Sulfonylation of O-Acyl Oximes via Iminyl Radicals with the Insertion of Sulfur Dioxide

Jun Zhang et al.

ORGANIC LETTERS (2019)

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Article Chemistry, Multidisciplinary

Regio- and Enantioselective Preparation of Chiral Allylic Sulfones Featuring Elusive Quaternary Stereocenters

Aijie Cai et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

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Article Chemistry, Organic

Hydrosulfonylation of Unactivated Alkenes by Visible Light Photoredox Catalysis

Juan-Juan Wang et al.

ORGANIC LETTERS (2019)

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Article Multidisciplinary Sciences

Modular synthesis of α-fluorinated arylmethanes via desulfonylative cross-coupling

Masakazu NamboD et al.

NATURE COMMUNICATIONS (2019)

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Review Chemistry, Applied

Recent Advances in Transition-Metal-Mediated Chelation- Assisted Sulfonylation of Unactivated C-H Bonds

Jidan Liu et al.

ADVANCED SYNTHESIS & CATALYSIS (2019)

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Article Chemistry, Multidisciplinary

Inorganic sulfites as the sulfur dioxide surrogates in sulfonylation reactions

Shengqing Ye et al.

CHEMICAL COMMUNICATIONS (2019)

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Article Chemistry, Multidisciplinary

A convenient access to allylic triflones with allenes and triflyl chloride in the presence of (EtO)2P(O)H

Jixiang Ni et al.

CHEMICAL COMMUNICATIONS (2019)

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Article Chemistry, Multidisciplinary

Preparation of Quaternary Centers via Nickel-Catalyzed Suzuki-Miyaura Cross-Coupling of Tertiary Sulfones

Zachary T. Ariki et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2018)

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Article Chemistry, Multidisciplinary

Dehydroxylation of alcohols for nucleophilic substitution

Jia Chen et al.

CHEMICAL COMMUNICATIONS (2018)

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Article Chemistry, Organic

Halogenation through Deoxygenation of Alcohols and Aldehydes

Jia Chen et al.

ORGANIC LETTERS (2018)

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Article Chemistry, Multidisciplinary

Oxidative β-C-H sulfonylation of cyclic amines

R. J. Griffiths et al.

CHEMICAL SCIENCE (2018)

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Article Multidisciplinary Sciences

Water-promoted C-S bond formation reactions

Peizhong Xie et al.

NATURE COMMUNICATIONS (2018)

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Review Chemistry, Multidisciplinary

Recent advances in the sulfonylation of alkenes with the insertion of sulfur dioxide via radical reactions

Guanyinsheng Qiu et al.

CHEMICAL COMMUNICATIONS (2018)

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Article Chemistry, Multidisciplinary

Benzylic C(sp3)-H bond sulfonylation of 4-methylphenols with the insertion of sulfur dioxide under photocatalysis

Xinxing Gong et al.

CHEMICAL COMMUNICATIONS (2018)

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Article Chemistry, Multidisciplinary

Electrochemical sulfonylation of thiols with sulfonyl hydrazides: a metal- and oxidant-free protocol for the synthesis of thiosulfonates

Zu-Yu Mo et al.

GREEN CHEMISTRY (2018)

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Article Chemistry, Organic

Direct Substitution of Secondary and Tertiary Alcohols To Generate Sulfones under Catalyst- and Additive-Free Conditions

Yanan Liu et al.

ORGANIC LETTERS (2018)

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Article Chemistry, Organic

A Protocol To Transform Sulfones into Nitrones and Aldehydes

Eduardo Rodrigo et al.

ORGANIC LETTERS (2018)

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Article Chemistry, Multidisciplinary

A mild light-induced cleavage of the S-O bond of aryl sulfonate esters enables efficient sulfonylation of vinylarenes

Maxim Ratushnyy et al.

CHEMICAL SCIENCE (2018)

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Article Chemistry, Multidisciplinary

Dehydrogenative Aromatization and Sulfonylation of Pyrrolidines: Orthogonal Reactivity in Photoredox Catalysis

Krishnamoorthy Muralirajan et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2018)

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Article Multidisciplinary Sciences

Rapid Dehydroxytrifluoromethoxylation of Alcohols

Wei Zhang et al.

ISCIENCE (2018)

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Article Chemistry, Multidisciplinary

Dual roles of sulfonyl hydrazides in the catalyst-free sulfonylation of unsaturated benzylic alcohols in water

Kun Xu et al.

GREEN CHEMISTRY (2017)

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Article Chemistry, Organic

Synthesis of Sulfones and Sulfonamides via Sulfinate Anions: Revisiting the Utility of Thiosulfonates

Pranab K. Shyam et al.

JOURNAL OF ORGANIC CHEMISTRY (2017)

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Article Chemistry, Multidisciplinary

Copper(I)-catalyzed sulfonylative Suzuki-Miyaura cross-coupling

Yiding Chen et al.

CHEMICAL SCIENCE (2017)

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Article Chemistry, Multidisciplinary

Palladium-catalyzed direct sulfonylation of C-H bonds with the insertion of sulfur dioxide

Hongguang Xia et al.

CHEMICAL COMMUNICATIONS (2017)

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Article Chemistry, Organic

Metal-Free Catalyzed Regioselective Allylic Trifluoromethanesulfonylation of Aromatic Allylic Alcohols with Sodium Trifluoromethanesulfinate

Jianhua Liao et al.

JOURNAL OF ORGANIC CHEMISTRY (2016)

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Article Chemistry, Organic

Arylative Desulfonation of Diarylmethyl Phenyl Sulfone with Arenes Catalyzed by Scandium Triflate

Masakazu Nambo et al.

ORGANIC LETTERS (2016)

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Review Chemistry, Multidisciplinary

Shelf-Stable Electrophilic Reagents for Trifluoromethylthiolation

Xinxin Shao et al.

ACCOUNTS OF CHEMICAL RESEARCH (2015)

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Article Chemistry, Multidisciplinary

One-Pot Synthesis of Allylic Sulfones, Ketosulfones, and Triflyl Allylic Alcohols from Domino Reactions of Allylic Alcohols with Sulfinic Acid under Metal-Free Conditions

Xue-Qiang Chu et al.

CHEMISTRY-A EUROPEAN JOURNAL (2015)

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Article Chemistry, Organic

Synthesis of Allenyl Sulfones via a TBHP/TBAI-Mediated Reaction of Propargyl Alcohols with Sulfonyl Hydrazides

Zheng Yang et al.

JOURNAL OF ORGANIC CHEMISTRY (2015)

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Review Chemistry, Multidisciplinary

Good Partnership between Sulfur and Fluorine: Sulfur-Based Fluorination and Fluoroalkylation Reagents for Organic Synthesis

Chuanfa Ni et al.

CHEMICAL REVIEWS (2015)

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Article Chemistry, Applied

Catalytic Stereospecific Substitution of Enantioenriched Allylic Alcohols with Sodium Sulfinates

Xian-Tao Ma et al.

ADVANCED SYNTHESIS & CATALYSIS (2014)

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Article Chemistry, Multidisciplinary

N-Trifluoromethylthiosaccharin: An Easily Accessible, Shelf-Stable, Broadly Applicable Trifluoromethylthiolating Reagent

Chunfa Xu et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2014)

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Article Chemistry, Medicinal

Design, Synthesis, and Biological Evaluation of (E)-3,4-Dihydroxystyryl Aralkyl Sulfones and Sulfoxides as Novel Multifunctional Neuroprotective Agents

Xianling Ning et al.

JOURNAL OF MEDICINAL CHEMISTRY (2014)

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Article Chemistry, Medicinal

Discovery of Vinyl Sulfones as a Novel Class of Neuroprotective Agents toward Parkinson's Disease Therapy

Seo Yeon Woo et al.

JOURNAL OF MEDICINAL CHEMISTRY (2014)

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Article Chemistry, Organic

Modular Synthesis of Sulfonyl Benzoheteroles by Silver-Catalyzed Heteroaromatization of Propargylic Alcohols with p-Toluenesulfonylmethyl Isocyanide (TosMIC): Dual Roles of TosMIC

Jianquan Liu et al.

ORGANIC LETTERS (2014)

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Article Chemistry, Organic

Copper-Catalyzed Direct Trifluoromethylthiolation of Benzylic C-H Bonds via Nondirected Oxidative C(sp3)-H Activation

Chao Chen et al.

ORGANIC LETTERS (2014)

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Article Chemistry, Multidisciplinary

Chiral Fluorinated α-Sulfonyl Carbanions: Enantioselective Synthesis and Electrophilic Capture, Racemization Dynamics, and Structure

Gunther Hellmann et al.

CHEMISTRY-A EUROPEAN JOURNAL (2013)

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Article Chemistry, Applied

Iron(III) Chloride-Catalyzed Direct Sulfonylation of Alcohols with Sodium Arenesulfinates

M. Amarnath Reddy et al.

ADVANCED SYNTHESIS & CATALYSIS (2010)

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Article Chemistry, Medicinal

Synthesis, Anti-Inflammatory Activity, and in Vitro Antitumor Effect of a Novel Class of Cyclooxygenase Inhibitors: 4-(Aryloyl)phenyl Methyl Sulfones

Youssef Harrak et al.

JOURNAL OF MEDICINAL CHEMISTRY (2010)

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Article Chemistry, Multidisciplinary

An Unexpected Reaction of Arenesulfonyl Cyanides with Allylic Alcohols: Preparation of Trisubstituted Allyl Sulfones

Leleti Rajender Reddy et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2009)

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Article Chemistry, Medicinal

Malaria-Infected Mice Are Cured by a Single Oral Dose of New Dimeric Trioxane Sulfones Which Are Also Selectively and Powerfully Cytotoxic to Cancer Cells

Andrew S. Rosenthal et al.

JOURNAL OF MEDICINAL CHEMISTRY (2009)

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Article Chemistry, Organic

An Expeditious Entry to Benzylic and Allylic Sulfones through Byproduct-Catalyzed Reaction of Alcohols with Sulfinyl Chlorides

Hai-Hua Li et al.

JOURNAL OF ORGANIC CHEMISTRY (2009)

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Article Chemistry, Organic

Pincer Complex-Catalyzed Redox Coupling of Alkenes with Iodonium Salts via Presumed Palladium(IV) Intermediates

Juhanes Aydin et al.

ORGANIC LETTERS (2009)

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Article Chemistry, Organic

Reduction of propargylic sulfones to (Z)-allylic sulfones using zinc and ammonium chloride

Helen M. Sheldrake et al.

TETRAHEDRON LETTERS (2007)

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Article Chemistry, Medicinal

Design, molecular modeling, synthesis, and anti-HIV-1 activity of new indolyl aryl sulfones. Novel derivatives of the indole-2-carboxamide

Rino Ragno et al.

JOURNAL OF MEDICINAL CHEMISTRY (2006)

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Review Chemistry, Multidisciplinary

α-Amido sulfones as stable precursors of reactive N-acylimino derivatives

M Petrini

CHEMICAL REVIEWS (2005)

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Article Chemistry, Multidisciplinary

Facile synthesis of aryl- and alkyl-bis(trifluoromethylsulfonyl)methanes

A Hasegawa et al.

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN (2005)

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Article Chemistry, Organic

Palladium-triethylborane-triggered direct and regioselective conversion of allylic alcohols to allyl phenyl sulfones

S Chandrasekhar et al.

JOURNAL OF ORGANIC CHEMISTRY (2005)

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Article Chemistry, Organic

Transformation of carbonates into sulfones at the benzylic position via palladium-catalyzed benzylic substitution

R Kuwano et al.

ORGANIC LETTERS (2005)

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Article Chemistry, Medicinal

Novel indolyl aryl sulfones active against HIV-1 carrying NNRTI resistance mutations: Synthesis and SAR studies

R Silvestri et al.

JOURNAL OF MEDICINAL CHEMISTRY (2003)

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Dehydroxylative Sulfonylation of Alcohols

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