期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 88, 期 7, 页码 4472-4480出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.2c03081
关键词
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Copper-catalyzed carboazidation of alkenes with trimethylsilyl azide and cyclic ethers has been achieved, allowing cyclic ethers to be used as alkylating reagents under oxidative conditions. Styrene derivatives and 1,1-diaryl alkenes can be used as starting materials to obtain carboazidation products. The reaction proceeds via a radical pathway, as shown by radical trapping and clock experiments.
Copper-catalyzed carboazidation of alkenes with trime-thylsilyl azide and cyclic ethers has been achieved. The employment of naturally abundant copper catalysts allowed cyclic ethers to be used as alkylating reagents under oxidative conditions. The use of styrene derivatives and 1,1-diaryl alkenes afforded carboazidation products. In addition, application of five-and six-membered cyclic ethers to the present reaction gave target organic molecules bearing azide and cyclic ether groups with perfect regioselectivity. Radical trapping and clock experiments revealed that the present reaction proceeded via the radical pathway. To further demonstrate the utility of this carboazidation reaction, transformations from the azide group to the related nitrogen-containing compounds were also performed.
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