期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 88, 期 11, 页码 7219-7227出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.3c00460
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We report the first-time use of a palladium-di-(1-adamantyl)-n-butylphosphine catalytic system for the synthesis of alk-2-ynamides via aminocarbonylation reaction. This method utilizes chloroform as an in situ CO source, avoiding the direct use of toxic CO gas. The mild condition provides alk-2-ynamides within 50 min under microwave irradiation at 80 degrees C.
Wedescribe the first-time use of a palladium-di-(1-adamantyl)-n-butylphosphine catalytic system for the synthesis of alk-2-ynamidesfrom terminal alkynes via aminocarbonylation reaction. This methodavoids the direct use of toxic CO gas by utilizing chloroform as anin situ CO source. The aminocarbonylation of both aromatic and aliphaticelectron-rich alkyne nucleophiles is reported for the first time.The mild condition provides alk-2-ynamides within 50 min under microwaveirradiation at 80 degrees C.
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