期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 88, 期 9, 页码 5300-5310出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.2c02709
关键词
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This study describes the visible-light photoredox intermolecular catalysis of N-arylacrylamides that are alpha-C-H functionalized with aryl tertiary amines. The photocatalyst serves as a chemical switch to trigger two different reaction pathways, leading to the synthesis of two different products from the same starting material. By adjusting the reaction conditions, oxidative cyclizations or addition products can be selectively synthesized with good to high yields and excellent atom economy.
The ability to selectively synthesize multiple products from the same sets of substrates is a highly appealing and challenging concept in synthetic chemistry. In this manuscript, we describe the visible-light photoredox intermolecular catalysis of N- arylacrylamides that are alpha-C-H functionalized with aryl tertiary amines. The photocatalyst acts as a chemical switch to trigger two different reaction pathways and to obtain two different products from the same starting material. Simple adjustments to the reaction conditions enable the divergent synthesis of the oxidative cyclizations or the addition products in good to high yields with excellent atom economy.
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