Three-Component Electrochemical Aminoselenation of 1,3-Dienes

Azoles and organoselenium compounds are pharmacologically important scaffolds in medicinal chemistry and natural products. We developed an efficient regioselective electrochemical aminoselenation reaction of 1,3-dienes, azoles, and diselenide derivatives to access selenium-containing allylazoles skeletons. This protocol is more economical and environmentally friendly and features a broad substrate scope; pyrazole, triazole, and tetrazolium were all tolerated under the standard conditions, which could be applied to the expedient synthesis of bioactive molecules and in the pharmaceutical industry.

Automated summary

Azoles and organoselenium compounds are important structures in medicinal chemistry and natural products. We developed an efficient regioselective electrochemical aminoselenation reaction for the synthesis of selenium-containing allylazoles. This protocol is cost-effective, environmentally friendly, and can be applied to the synthesis of bioactive molecules in the pharmaceutical industry.