4.7 Article

Catalyst- and Base-Free Synthesis of Morita-Baylis-Hillman and Rauhut-Currier Adducts of ?-Aminonitroalkenes

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Summary: This study presents a facile, metal-free method for the synthesis of substituted alpha-carbolines from secondary Morita-Baylis-Hillman acetates of nitroalkenes. The regioselective cascade reaction of MBH acetates with tosyliminoindolines leads to the formation of various alpha-carbolines with a wide substrate scope. The reaction occurs under mild conditions and yields products in high amounts within a short reaction time, showing scalability and potential synthetic applications.

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