4.7 Article

Catalyst- and Base-Free Synthesis of Morita-Baylis-Hillman and Rauhut-Currier Adducts of ?-Aminonitroalkenes

期刊

JOURNAL OF ORGANIC CHEMISTRY
卷 88, 期 7, 页码 4799-4808

出版社

AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.2c02969

关键词

-

向作者/读者索取更多资源

A facile, base-and catalyst-free synthesis of Morita-Baylis-Hillman and Rauhut-Currier adducts of fi-aminonitroalkenes with different electrophiles is reported. The reactions with ethyl glyoxylate, trifluoropyruvate, ninhydrin, vinyl sulfone, and N-tosylazadiene result in good to excellent yields of products at room temperature. The adducts of ninhydrin and fi-aminonitroalkene spontaneously cyclize to fused indenopyrroles. Gram-scale reactions and synthetic transformations of the adducts are also reported.
A facile, base-and catalyst-free synthesis of Morita???Baylis???Hillman and Rauhut???Currier adducts of fi-aminonitroalkenes with different electrophiles such as ethyl glyoxylate, trifluoropyruvate, ninhydrin, vinyl sulfone, and N-tosylazadiene is reported. The products are formed in good to excellent yields at room temperature with a broad substrate scope. The adducts of ninhydrin and fi-aminonitroalkene spontaneously cyclize to fused indenopyrroles. Gram-scale reactions and synthetic transformations of the adducts are also reported here.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据