4.2 Article

Carbonic Anhydrase Inhibitor Modulation of Intraocular Pressure Is Independent of Soluble Adenylyl Cyclase

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Multidisciplinary Sciences

On-demand male contraception via acute inhibition of soluble adenylyl cyclase

Melanie Balbach et al.

Summary: This proof-of-concept study validates an on-demand contraception strategy for men, showing high effectiveness in quickly and temporarily reducing male fertility in mice. The study provides an innovative approach for male contraception and demonstrates the feasibility of on-demand and pharmacological contraception for men.

NATURE COMMUNICATIONS (2023)

Article Pharmacology & Pharmacy

Strategies to safely target widely expressed soluble adenylyl cyclase for contraception

Jacob Ferreira et al.

Summary: This article discusses the 10 isoforms of adenylyl cyclase that produce the second messenger cyclic AMP in humans, including nine G protein-coupled transmembrane adenylyl cyclases (tmACs; ADCY1-9) and one bicarbonate-regulated soluble adenylyl cyclase (sAC; ADCY10). It highlights the unique druggability of sAC and outlines approaches to target sAC for novel forms of male and female contraception.

FRONTIERS IN PHARMACOLOGY (2022)

Article Developmental Biology

Soluble adenylyl cyclase inhibition prevents human sperm function essential for fertilization

Melanie Balbach et al.

Summary: sAC, essential for male fertility, is required for sperm capacitation and motility. A new sAC inhibitor, TDI-10229, disrupts capacitation-induced changes in mouse and human sperm, showing potential as non-hormonal contraceptives for women.

MOLECULAR HUMAN REPRODUCTION (2021)

Article Chemistry, Medicinal

Discovery of TDI-10229: A Potent and Orally Bioavailable Inhibitor of Soluble Adenylyl Cyclase (sAC, ADCY10)

Makoto Fushimi et al.

Summary: In this study, a successful design of sAC inhibitor TDI-10229 (12) was described, showing nanomolar inhibition of sAC in both biochemical and cellular assays, with mouse pharmacokinetic properties suitable for in vivo use as a tool compound.

ACS MEDICINAL CHEMISTRY LETTERS (2021)

Review Medicine, Research & Experimental

Emerging role of carbonic anhydrase inhibitors

Claudiu T. Supuran

Summary: Inhibition of carbonic anhydrase has been used clinically for various applications including treating glaucoma, epilepsy, obesity, and cancer. Recent studies have discovered new roles of CA isoforms in areas like pain management, Alzheimer's disease, and oxidative stress, leading to potential novel clinical applications. Additionally, inhibition of CA in pathogenic microorganisms is being explored for new anti-infective drugs.

CLINICAL SCIENCE (2021)

Review Biochemistry & Molecular Biology

Structure and function of carbonic anhydrases

Claudiu T. Supuran

BIOCHEMICAL JOURNAL (2016)

Review Ophthalmology

Control of Outflow Resistance by Soluble Adenylyl Cyclase

Yong Suk Lee et al.

JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS (2014)

Article Multidisciplinary Sciences

Crystal structures of human soluble adenylyl cyclase reveal mechanisms of catalysis and of its activation through bicarbonate

Silke Kleinboelting et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Ophthalmology

Nonpigmented Ciliary Epithelial Cells Respond to Acetazolamide by a Soluble Adenylyl Cyclase Mechanism

Mohammad Shahidullah et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2014)

Article Biochemistry & Molecular Biology

CO2/HCO3-- and Calcium-regulated Soluble Adenylyl Cyclase as a Physiological ATP Sensor

Jonathan H. Zippin et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2013)

Article Biochemistry & Molecular Biology

Regulation of Anterior Chamber Drainage by Bicarbonate-sensitive Soluble Adenylyl Cyclase in the Ciliary Body

Yong S. Lee et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Article Ophthalmology

Effect of Elevated Intracellular cAMP Levels on Actomyosin Contraction in Bovine Trabecular Meshwork Cells

Charanya Ramachandran et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2011)

Article Cell Biology

Cyclic AMP Produced inside Mitochondria Regulates Oxidative Phosphorylation

Rebeca Acin-Perez et al.

CELL METABOLISM (2009)

Article Medicine, Research & Experimental

Modulation of mitochondrial protein phosphorylation by soluble adenylyl cyclase ameliorates cytochrome oxidase defects

Rebeca Acin-Perez et al.

EMBO MOLECULAR MEDICINE (2009)

Article Ophthalmology

Studies on Bicarbonate Transporters and Carbonic Anhydrase in Porcine Nonpigmented Ciliary Epithelium

Mohammad Shahidullah et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2009)

Article Ophthalmology

Forskolin induces myosin light chain dephosphorylation in bovine trabecular meshwork cells

Charanya Ramachandran et al.

CURRENT EYE RESEARCH (2008)

Article Multidisciplinary Sciences

Mice deficient for soluble adenylyl cyclase are infertile because of a severe sperm-motility defect

G Esposito et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

Article Ophthalmology

Aqueous humor dynamics in mice

M Aihara et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2003)

Article Biochemistry & Molecular Biology

Compartmentalization of bicarbonate-sensitive adenylyl cyclase in distinct signaling microdomains

JH Zippin et al.

FASEB JOURNAL (2002)

Review Endocrinology & Metabolism

CO2/HCO3--responsive soluble adenylyl cyclase as a putative metabolic sensor

JH Zippin et al.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2001)

Article Multidisciplinary Sciences

Soluble adenylyl cyclase as an evolutionarily conserved bicarbonate sensor

YQ Chen et al.

SCIENCE (2000)