4.2 Review

Radiation-induced lymphopenia and the survival of women with cervical cancer: a meta-analysis

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Oncology

Meta-analysis and Critical Review: Association Between Radio-induced Lymphopenia and Overall Survival in Solid Cancers

Yasmine El Houat et al.

Summary: The use of immune checkpoint inhibitors has revolutionized the field of oncology by modulating the immune system. This meta-analysis investigates the association between radio-induced lymphopenia and overall survival in cancer patients treated with radiation therapy.

ADVANCES IN RADIATION ONCOLOGY (2023)

Article Oncology

Early onset of severe lymphopenia during definitive radiotherapy correlates with mean body dose and predicts poor survival in cervical cancer

Li Yang et al.

Summary: This study examined the prognostic significance of early onset of severe lymphopenia (EOSL) during definitive radiotherapy (RT) in patients with cervical cancer. The study found that EOSL correlated with mean body dose (MBD) and predicted poor survival in these patients.

CANCER BIOMARKERS (2022)

Article Oncology

Radiotherapy of cervical cancer

C. Chargari et al.

Summary: External beam radiotherapy and brachytherapy are commonly used treatments for cervical cancer. The choice of preoperative or postoperative brachytherapy or chemoradiation depends on the tumor stage, with brachytherapy boost being performed when necessary.

CANCER RADIOTHERAPIE (2022)

Article Oncology

Positron Emission Tomography-Guided Bone Marrow-Sparing Radiation Therapy for Locoregionally Advanced Cervix Cancer: Final Results From the INTERTECC Phase II/III Trial

Casey W. Williamson et al.

Summary: This study aimed to investigate the effects of PET-BMS-IMRT on efficacy and toxicity for patients with locoregionally advanced cervical cancer. The results showed that PET-BMS-IMRT significantly reduced acute grade >= 3 neutropenia compared with standard IMRT, without affecting long-term outcomes. There was weak evidence of an association between pretreatment ALC and OS.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2022)

Review Oncology

Global challenges of radiotherapy for the treatment of locally advanced cervical cancer

Jyoti S. Mayadev et al.

Summary: Cervical cancer is a significant burden for women worldwide, with low- and middle-income countries being most affected. Underserved populations in countries with sufficient resources may also have higher incidence and poorer outcomes. Current standard treatment for locally advanced cervical cancer is effective but faces barriers related to adherence, limited access to radiotherapy, and underutilization of brachytherapy. Efforts are being made to address these barriers and explore additional therapies to improve treatment efficacy.

INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER (2022)

Article Oncology

Cancer treatment and survivorship statistics, 2022

Kimberly D. Miller et al.

Summary: The number of cancer survivors in the United States is increasing due to population growth, aging, and improved detection and treatment. The most prevalent cancers are prostate, skin melanoma, and colon and rectum for males, and breast, uterine corpus, and thyroid for females. Treatment disparities exist, with Black patients being less likely to be diagnosed with early-stage cancer and having lower surgical receipt rates.

CA-A CANCER JOURNAL FOR CLINICIANS (2022)

Article Oncology

Exponential Slope from Absolute Lymphocyte Counts during Radio-Chemotherapy Can Predict an Aggressive Course of Cervical Cancer

Oyeon Cho et al.

Summary: Lymphopenia has implications for cancer progression, treatment effects, and immune capacity. The exponential slope alpha from absolute lymphocyte counts can potentially distinguish between aggressive and non-aggressive courses in cervical cancer patients.

CANCERS (2022)

Article Oncology

A machine learning model for grade 4 lymphopenia prediction during pelvic radiotherapy in patients with cervical cancer

Zhiyuan Xu et al.

Summary: This study developed and validated a comprehensive model integrating clinical and dosimetric parameters using a machine learning method to predict grade 4 lymphopenia during pelvic radiotherapy for cervical cancer. The model showed good predictive ability in the test set, facilitating physicians in identifying high-risk patients who may benefit from modified treatment approaches.

FRONTIERS IN ONCOLOGY (2022)

Article Obstetrics & Gynecology

Impact of hematologic toxicities during concurrent chemoradiation for cervical cancer

Feiya Shi et al.

Summary: This study evaluated the prognostic significance of hematological toxicities during cervical cancer treatment and found that severe lymphopenia was associated with reduced overall survival and progression-free survival in Hispanic women undergoing chemoradiation.

OBSTETRICS & GYNECOLOGY SCIENCE (2022)

Editorial Material Surgery

Vaginal Stenosis After Cervical Cancer Treatments: Challenges for Reconstructive Surgery

Antonio Simone Lagana et al.

JOURNAL OF INVESTIGATIVE SURGERY (2021)

Review Medicine, General & Internal

PRISMA 2020 explanation and elaboration: updated guidance and exemplars for reporting systematic reviews

Matthew J. Page et al.

Summary: The methods and results of systematic reviews should be reported in sufficient detail to allow users to assess trustworthiness. PRISMA 2020 aims to improve the transparency and completeness of systematic review reporting, in hopes of guiding more accurate and transparent reporting.

BMJ-BRITISH MEDICAL JOURNAL (2021)

Review Medicine, General & Internal

The PRISMA 2020 statement: an updated guideline for reporting systematic reviews

Matthew J. Page et al.

Summary: The PRISMA statement was designed to help systematic reviewers transparently report the purpose, methods, and findings of their reviews. The updated PRISMA 2020 statement includes new reporting guidance, a 27-item checklist, an abstract checklist, and revised flow diagrams for reviews.

BMJ-BRITISH MEDICAL JOURNAL (2021)

Review Oncology

The Influence of Severe Radiation-Induced Lymphopenia on Overall Survival in Solid Tumors: A Systematic Review and Meta-Analysis

Pim J. J. Damen et al.

Summary: This study systematically reviewed and meta-analyzed the prognostic impact of radiation-induced lymphopenia (RIL) on overall survival (OS) in patients with solid tumors. The results demonstrated a significant detrimental prognostic association between grade >= 3 lymphopenia and OS, especially in tumors of the brain, thorax, and upper abdomen. Further research is needed to explore strategies to mitigate lymphopenia and potentially improve survival outcomes in these patients.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2021)

Review Oncology

Immune correlates of therapy outcomes in women with cervical cancer treated with chemoradiotherapy: A systematic review

David S. Lakomy et al.

Summary: Immune markers have been shown to correlate with prognosis in patients with cervical cancer treated with chemoradiation, with lymphopenia and elevated neutrophil-to-lymphocyte ratio being identified as strong prognostic indicators. Other potential markers include HPV-specific lymphocyte response, cytokine profile, and tumor-associated immune cell infiltration.

CANCER MEDICINE (2021)

Article Oncology

Is a Vaginectomy Enough or is a Pelvic Exenteration Always Required for Surgical Treatment of Recurrent Cervical Cancer? A Propensity-Matched Study

Giuseppe Vizzielli et al.

Summary: This study retrospectively analyzed the perioperative and survival outcomes of vaginectomy and pelvic exenteration (PE) in women with recurrent cervical cancer. The results showed that vaginectomy had lower postoperative complications, lower recurrence rate, and longer survival time compared to PE, indicating that vaginectomy may be an effective treatment option for women with recurrent cervical cancer.

ANNALS OF SURGICAL ONCOLOGY (2021)

Article Oncology

Mechanisms of radiation-induced lymphopenia and therapeutic impact

Mathieu Cesaire et al.

BULLETIN DU CANCER (2020)

Review Medicine, General & Internal

Cervical cancer

Paul A. Cohen et al.

LANCET (2019)

Review Oncology

A systematic review of the influence of radiation-induced lymphopenia on survival outcomes in solid tumors

Bhanu Prasad Venkatesulu et al.

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2018)

Article Oncology

Quality of Life in Women After Pelvic Exenteration for Gynecological Malignancies A Multicentric Study

Margherita Dessole et al.

INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER (2018)

Review Multidisciplinary Sciences

Cancer Immunoediting: Integrating Immunity's Roles in Cancer Suppression and Promotion

Robert D. Schreiber et al.

SCIENCE (2011)

Article Public, Environmental & Occupational Health

Sensitivity of between-study heterogeneity in meta-analysis: proposed metrics and empirical evaluation

Nikolaos A. Patsopoulos et al.

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY (2008)

Article Mathematical & Computational Biology

Quantifying heterogeneity in a meta-analysis

JPT Higgins et al.

STATISTICS IN MEDICINE (2002)